Role of cephalosporins in the treatment of bacterial meningitis in adults

Norrby, S. Ragnar

doi:10.1016/0002-9343(85)90262-1

Cited by 55 publications

(34 citation statements)

References 37 publications

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“…2 Both patients had nodal metastases in the neck after cranial radiation, which raises the issue of malignant transformation of a benign pituitary adenoma. In contrast to the first patient, our patient had a negative octreotide scan.…”

Section: Pituitary Carcinoma As a Cause Of Acromegalymentioning

confidence: 99%

“…2,3 Indeed, in the second Randomised Intervention Treatment of Angina (RITA-2) trial, 3 patients who underwent angioplasty had a significant 91 percent increase (a 3 percent absolute difference) in the rate of death or myocardial infarction during a median of 2.7 years of follow-up. The early randomized, controlled trials comparing coronary surgery with medical treatment also failed to show an improvement in prognosis among patients without stenosis of the left main coronary artery and with good left ventricular function.…”

Section: Coronary-artery Bypass Surgery Versus Stenting For Multivessmentioning

confidence: 99%

“…2 Such an elevation does not reflect perioperative myocardial infarction unless it continues for 24 to 48 hours. 2 Most clinicians understand that, in practice, surgery and angioplasty are used to deal with different spectrums of severity of ischemic heart disease. Suggesting that both techniques are equally efficacious, on the basis of results in a highly selected population of patients with "multivessel" disease (i.e., primarily two-vessel disease and normal ventricular function), serves only to confuse the issue, the general physician, and the patient.…”

Section: Coronary-artery Bypass Surgery Versus Stenting For Multivessmentioning

confidence: 99%

“…Effective treatment of P. aeruginosa meningitis requires high doses of a third-generation cephalosporin with adequate penetration of the cerebrospinal fluid, such as ceftazidime. 2 Aminoglycosides may be used as adjunctive treatment in severe cases or if the initial therapy fails or there is a relapse. Other agents that have good in vitro activity and adequate penetration and for which there are reports of clinical success include meropenem, 3 …”

Section: Glanders In a Military Research Microbiologistmentioning

confidence: 99%

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Pituitary Carcinoma as a Cause of Acromegaly

Roux¹,

Mulla²,

Meeran³

2001

N Engl J Med

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In a trial comparing coronary-artery bypass surgery with stenting for the treatment of multivessel coronary disease, Serruys et al. (April 12 issue) 1 conclude that both treatments offer protection against death, stroke, and myocardial infarction. We disagree. Whether there is "protection" can be determined only through comparison with a group of patients who are assigned to medical therapy alone.To date, no clinical trial comparing angioplasty with medical therapy for angina has demonstrated a protective effect of angioplasty in multivessel disease.2,3 Indeed, in the second Randomised Intervention Treatment of Angina (RITA-2) trial, 3 patients who underwent angioplasty had a significant 91 percent increase (a 3 percent absolute difference) in the rate of death or myocardial infarction during a median of 2.7 years of follow-up. The early randomized, controlled trials comparing coronary surgery with medical treatment also failed to show an improvement in prognosis among patients without stenosis of the left main coronary artery and with good left ventricular function. 4 Neither of these treatment options has been shown to offer protection against myocardial infarction or stroke. These results can be explained by the fact that risk of plaque rupture is determined not by the patency of the vessel but by the stability of the atheromatous plaque: most episodes of acute coronary occlusion occur in vessels with stenoses that are not flow-limiting (those resulting in a reduction of less than 70 percent in the luminal diameter).5 These two treatments are palliative, and to portray them as protective is misleading.

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Section: Pituitary Carcinoma As a Cause Of Acromegalymentioning

confidence: 99%

Section: Coronary-artery Bypass Surgery Versus Stenting For Multivessmentioning

confidence: 99%

Section: Coronary-artery Bypass Surgery Versus Stenting For Multivessmentioning

confidence: 99%

Section: Glanders In a Military Research Microbiologistmentioning

confidence: 99%

See 2 more Smart Citations

Pituitary Carcinoma as a Cause of Acromegaly

Roux¹,

Mulla²,

Meeran³

2001

N Engl J Med

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Section: Coronary-artery Bypass Surgery Versus Stenting For Multivessmentioning

confidence: 99%

CutaneousBacillus anthracisInfection

Gallagher¹,

Strober²

2001

N Engl J Med

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Ceftazidime-Related Nonconvulsive Status Epilepticus

Klion

Kallsen

Cowl³

et al. 1994

Arch Intern Med

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The third-generation cephalosporin, ceftazidime, is widely used for the treatment of serious gram-negative infections. As is true of cephalosporins in general, reported adverse effects have been few. We report a case of ceftazidime-induced status epilepticus in a patient with Pseudomonas aeruginosa meningitis and compare the clinical manifestations of this case with those of two previously described cases of ceftazidime-related encephalopathy. This diagnosis should be entertained and an electroencephalogram should be obtained in all patients with myoclonus and/or altered mental status while they are receiving ceftazidime therapy.

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Role of cephalosporins in the treatment of bacterial meningitis in adults

Cited by 55 publications

References 37 publications

Pituitary Carcinoma as a Cause of Acromegaly

Pituitary Carcinoma as a Cause of Acromegaly

CutaneousBacillus anthracisInfection

Ceftazidime-Related Nonconvulsive Status Epilepticus

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