Role of Central Cholinoceptors in Cardiovascular Regulation

Tangri, K.K.; Jain, I.P.; Bhargava, K. P.

doi:10.1016/s0079-6123(08)62718-1

Cited by 9 publications

(1 citation statement)

References 16 publications

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“…Increases in blood pressure also have been reported in both the conscious dog [Lang and Rush, 19731 and conscious cat [Day and Roach, 19771 following injection of ACh into the lateral cerebral ventricle. In anesthetized dogs and cats, however, central cholinergic stimulation by muscarinic or nicotinic agonists has been reported to cause variable pressor or depressor effects [Hhawe, 1958;Armitage and Hall, 1967;Tangri and Bhargava, 1977;Dage, 19791. It appears that anesthetics, especially chloralose and barbiturates, may obtund hypertensive effects produced by stimulation of central cholinergic receptors.…”

Section: Cardiovascular Response To Central Cholinergic Stimulationmentioning

confidence: 99%

The role of brain acetylcholine in cardiovascular regulation and hypertension: A minireview and therapeutic implications

Brezenoff¹,

Coram²

1982

Drug Development Research

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Brezenoff, H.E., and W.M. Coram: The role of brain acetylcholine in cardiovascular regulation and hypertension: A minireview and therapeutic implications. Drug Dev. Res. 2251Res. -258. 1982 Acetylcholine in the central nervous system exerts a significant influence on cardiovascular parametzrs and appears to be involved in some aspects of hypertension. Stimulation of central muscarinic receptors with direct-acting cholinomimetics or with acetylcholinesterase inhibitors evokes a rise in blood pressure in unanesthetized cats, dogs, rats, and humans. Anesthetics may significantly modify this response. Concomitant with the pressor response is a potentiation of reflex bradycardia, inhibition of reflex tachycardia, and enhancement of the pressor reflex to carotid artery occlusion. Administration of atropine or intracerebroventricular injection of hemicholiniurn-3 reduces blood pressure in spontaneously hypertensive rats (SHR) but not in normotensive rats. Preliminary results are presented showing that systemic or central injection of N-(4-diethyl-2-butynyl)-succinimide, a muscarinic receptor antagonist specific for central receptors, also reduces blood pressure in SHR but not in normotensive animals.

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Section: Cardiovascular Response To Central Cholinergic Stimulationmentioning

confidence: 99%

The role of brain acetylcholine in cardiovascular regulation and hypertension: A minireview and therapeutic implications

Brezenoff¹,

Coram²

1982

Drug Development Research

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Central effects of paraoxon on haemodynamics in the cat

Neef

Porsius

1981

Naunyn-Schmiedeberg's Arch. Pharmacol.

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Application of paraoxon into the left vertebral artery (8--80 micrograms) or both the left and right vertebral artery (4--8 micrograms) of the anaesthetized cat evoked dose-dependent depressor effects, whereas heart rate was not influenced significantly. Also after systemic administration of paraoxon (150--825 micrograms . kg-1), while peripheral muscarinic receptors were blocked, depressor effects were still observed. Dose-response curves for the depressor response to paraoxon were established. Infusion of low doses of dexetimide via the vertebral artery prevented the hypotensive action of paraoxon. The distribution of this antimuscarinic drug in the brain was investigated. The depressor effect of paraoxon can be attributed to both a decrease in peripheral resistance and cardiac output. Decerebration and midcollicular transection were carried out in order to elucidate the site and mechanism of action. The depressor effect of paraoxon seems to be mediated by a central mechanism of action located within the lower brain stem. It is concluded that stimulation of muscarinic receptors in the pontomedullary region gives rise to the observed changes in haemodynamic parameters. Muscarinic receptors in the hypothalamus seem to be of minor importance for the hypotensive action of paraoxon.

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