Role of central adenosine in the respiratory and thermoregulatory responses to hypoxia

Barros, Renata C.H.; Branco, Luiz Guilherme de Siqueira

doi:10.1097/00001756-200001170-00038

Cited by 38 publications

(21 citation statements)

References 14 publications

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“…T b fell by ϳ2°C, which is comparable to T b changes observed in other small mammals, including primates over similar time courses (12,19). Numerous previous studies suggest a drop in the thermoregulatory set point in hypoxia (2,8,9,14,16,31,36) rather than a substrate limitation-induced hypothermia. In fact, the pygmy marmoset demonstrated an almost dose response to hypoxia, with a greater drop in T b occurring at lower O 2 levels and small drops in T b occurring at rather high levels of O 2 (Fig.…”

Section: Thermoregulatory and Metabolic Responses To Hypoxiasupporting

confidence: 78%

Ventilatory and metabolic responses to hypoxia in the smallest simian primate, the pygmy marmoset

Tattersall

Blank

Wood

2002

Journal of Applied Physiology

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Tattersall, Glenn J., James L. Blank, and Stephen C. Wood. Ventilatory and metabolic responses to hypoxia in the smallest simian primate, the pygmy marmoset. J Appl Physiol 92: 202-210, 2002; 10.1152/japplphysiol.00500.2001.-The pygmy marmoset (Cebuella pygmaea) is the smallest New World Monkey (average body mass of 120-130 g). As such, it faces possible challenges to thermoregulation. Small mammals (e.g., rats) are well known to lower body temperature and metabolism in response to hypoxia; however, small primates have not been studied in this respect nor have, in general, the interactions between metabolism and ventilation. Because little is known about these responses in small primates, it seemed of great interest to assess the hypoxiainduced metabolic depression and drop in body temperature and the associated ventilatory requirements in this species under hypoxic conditions. Exposure to graded hypoxia (30 min at each of 18, 16, 14, 12, and 10% O2) caused body temperature to drop from the normoxic value of 39 to 37°C. This was accompanied by a marked metabolic depression (O2 consumption was ϳ68% of the normoxic value, implying a suppression of metabolism greater than that predicted from a typical value of the effect of 10°C change on metabolism of 2-3 times). Minute ventilation declined in parallel to metabolism, maintaining a constant air-convection requirement during hypoxia; thus this species did not show the typical mammalian hyperventilation. Acute exposure to 10% O2 led to a similar overall decline in metabolism and body temperature and qualitative differences in the timing of these changes. The pygmy marmoset shares some similarities in its hypoxic metabolic response with other mammals of similar size yet appears to be unique in its much diminished ventilatory response to hypoxia. body temperature; thermoregulation; hypoxic ventilatory response; hypothermia; metabolic depression MANY ANIMALS RESPOND TO HYPOXIA by reducing body temperature (T b ) and metabolic rate (46). Since the 1950s, this was known to occur in a broad range of small mammals (18) and in neonates of larger mammals, including humans (10, 25). This hypoxia-induced drop in T b and metabolic depression serves a protective role by reducing O 2 demand, eliminating costly thermogenesis, improving blood O 2 affinity, and reducing the costs of ventilation (14,27,36,38,47,48). Furthermore, numerous studies support the conclusion that hypoxia resets the hypothalamic thermoregulatory set point to a lower level (9,(15)(16)(17)34), suggesting that this is a regulated process.Metabolism and thermoregulation affect ventilatory control (13, 30). Pulmonary ventilation is controlled so that O 2 delivery matches metabolic rate under varying states of metabolic demand (24). Thus breathing during hypoxic exposure is complicated by reduced metabolism and T b in small mammals. Lowered T b and metabolic rate decrease the metabolic drive to breathe (13), whereas hypoxia serves to increase the chemical drive to breathe. These drives for breathing conflict with o...

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Section: Thermoregulatory and Metabolic Responses To Hypoxiasupporting

confidence: 78%

Ventilatory and metabolic responses to hypoxia in the smallest simian primate, the pygmy marmoset

Tattersall

Blank

Wood

2002

Journal of Applied Physiology

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“…Adenosine mechanisms were originally implicated in the central nervous regulation of breathing in several species (Hedner et al, 1982;Mueller et al, 1984;Wessberg et al, 1984;Eldridge and Millhorn, 1987;Norsted et al, 1987;Bissonette et al, 1991;Barros and Branco, 2000). Adenosine injected into the caudal nucleus of the NTS decreased respiratory frequency by an action on A 2A receptors expressed on glutamatergic nerve terminals (Phillis et al, 1997).…”

Section: Central Control Of Respirationmentioning

confidence: 99%

Purinergic Signaling in the Airways

Burnstock

Brouns²,

Adriaensen³

et al. 2012

Pharmacol Rev

159

158

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“…Por outro lado, adenosina (Barros e Branco, 2000) e monóxido de carbono (Paro e col., 2001) parecem atuar em algum outro sítio no SNC para induzir e inibir, respectivamente, a anapirexia hipóxica.…”

Section: Anapirexiaunclassified

Regulação da temperatura corporal em diferentes estados térmicos: ênfase na anapirexia.

Scarpellini¹,

Bícego²

2010

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Resumo. Indiscutivelmente a temperatura é um dos principais fatores que afetam os processos fisiológicos e bioquímicos. Por isso, o estudo de como os animais regulam sua temperatura corporal (Tc) e respondem às alterações da temperatura ambiente é imprescindível. Os cinco estados térmicos definidos até o momento incluem eutermia, hipo e hipertermia (queda e aumento, respectivamente, da Tc devido à incapacidade de mantê-la sem variação), febre e anapirexia (aumento e queda regulados, respectivamente, da Tc). Nesta revisão são apresentados alguns dados clássicos e recentes sobre mecanismos termorreguladores envolvidos nesses estados térmicos e especial atenção é direcionada à anapirexia, um estado menos conhecido e que tem atraído a atenção dos pesquisadores devido ao seu potencial terapêutico.Palavras-chave. Área pré-óptica, hipóxia, receptores opióides. BODY TEMPERATURE REGULATION IN DIFFERENT THERMAL STATES: FOCUS ON ANAPYREXIAAbstract. Temperature is certainly one of the major factors that affect biochemical and physiological processes. So, the investigation of how animals regulate body temperature (Tb) and respond to changes in ambient temperature is indispensable. There are five thermal states defined up to date that include euthermy, hypo and hyperthermia (forced fall and increase of Tb, respectively), fever and anapyrexia (regulated increase and fall of Tb, respectively). In this review, we present some classic and recent data about thermoregulatory mechanisms involved in those thermal states with special attention directed to anapyrexia, a phenomenon that has attracted the interest of researchers due to its potential therapeutic benefits.

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Role of central adenosine in the respiratory and thermoregulatory responses to hypoxia

Cited by 38 publications

References 14 publications

Ventilatory and metabolic responses to hypoxia in the smallest simian primate, the pygmy marmoset

Ventilatory and metabolic responses to hypoxia in the smallest simian primate, the pygmy marmoset

Purinergic Signaling in the Airways

Regulação da temperatura corporal em diferentes estados térmicos: ênfase na anapirexia.

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