Role of cell block immunohistochemistry in early diagnosis of lymphoma.

Abstract

Background: Cell block immunohistochemistry (IHC) is an important adjunct for diagnosis of tumour. However, its usefulness in the diagnosis of lymphoma is yet to be established.Objective: We wanted to assess the reliability of cell block IHC in the diagnosis and classification of lymphoma.Methods: This cross-sectional study was carried out among 17 patients with enlarged lymphnode in cytopathology department of Bangabandhu Sheikh Mujib Medical University.Results: IHC could give either positive or negative result in 12 cases, leaving 5 cases as inconclusive, which lead us to remove them from analysis. Cell block IHC diagnosed 9 cases (75%) cases as positive for lymphoma and 3 cases (25%) as negative for lymphoma. The sensitivity, specificity, accuracy, strength, positive predictive value and negative predictive value of cell block IHC were 100% when assessed with final diagnosis based on histopathology and clinical outcome.Conclusion: Cell block IHC could be a useful tool for early diagnosis of lymphoma.International Journal of Human and Health Sciences Vol. 08 No. 02 Apr’24 Page: 203-206