Role of CD1d- and MR1-Restricted T Cells in Asthma

Iwamura, Chiaki; Nakayama, Toshinori

doi:10.3389/fimmu.2018.01942

Cited by 26 publications

(21 citation statements)

References 106 publications

(144 reference statements)

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“…In the allergy, the role of NKT cells is to maintain the Th1/Th2 balance by involving endo- and exogenous ligands for toll-like receptor 4 (TLR4) in iNKT cells [ 31 ]. There are reports showing the increased concentration of iNKT cells in bronchoalveolar lavage as well as in the peripheral blood in people with the exacerbation of bronchial asthma [ 32 , 33 ]. Similar observations were made in the case of atopic dermatitis.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Immunological Patterns of Allergic Diseases in Children

et al. 2021

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Vitamin D, in addition to its superior role as a factor regulating calcium-phosphate metabolism, shows wide effects in other processes in the human body, including key functions of the immune system. This is due to the presence of vitamin D receptors in most cells of the human body. In our study, we aimed to assess whether there is a correlation between vitamin D content and the clinical course of allergic diseases as well as establish their immunological parameters in children. We found that vitamin D deficiency was significantly more frequent in the group of children with an allergic disease than in the control group (p = 0.007). Statistically significant higher vitamin D concentrations in blood were observed in the group of children with a mild course of the disease compared to children with a severe clinical course (p = 0.03). In the group of children with vitamin D deficiency, statistically significant lower percentages of NKT lymphocytes and T-regulatory lymphocytes were detected compared to the group of children without deficiency (respectively, p = 0.02 and p = 0.05), which highlights a potential weakness of the immune system in these patients. Furthermore, statistically higher levels of interleukin-22 were observed in the group of children with vitamin D deficiency (p = 0.01), suggesting a proinflammatory alert state. In conclusion, these results confirm the positive relationship between the optimal content of vitamin D and the lesser severity of allergic diseases in children, establishing weak points in the immune system caused by vitamin D deficiency in children.

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Section: Discussionmentioning

confidence: 99%

Vitamin D and Immunological Patterns of Allergic Diseases in Children

et al. 2021

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“…The activated iNKT cells worsen the symptoms of allergic asthma independently of Th2‐cell‐mediated pathways. NKT cells are activated following antigenic stimulation in a CD1d‐dependent manner, as CD1d‐dependent antagonists or anti‐CD1d antibodies suppress OVA‐induced airway inflammation and histamine release 60 . The iNKT cells produce various cytokines such as IL‐4, IL‐5, IL‐13 and IL‐17 61 .…”

Section: Il‐27 Therapy Of Airway Allergies Targets the Innate Immune mentioning

confidence: 99%

“…NKT cells are activated following antigenic stimulation in a CD1d-dependent manner, as CD1d-dependent antagonists or anti-CD1d antibodies suppress OVA-induced airway inflammation and histamine release. 60 The iNKT cells produce various cytokines such as IL-4, IL-5, IL-13 and IL-17. 61 Along with ILC2, iNKT2 possesses the ability to respond to IL-25 and produce IL-13.…”

Section: Il-27 Reduces Granulocytes Infiltration and Functions In Amentioning

confidence: 99%

The immunomodulatory potentials of interleukin‐27 in airway allergies

et al. 2020

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Allergic airway disorders such as asthma and allergic rhinitis are mainly caused by inhaled allergen‐induced improper activation and responses of immune and non‐immune cells. One important response is the production of IL‐27 by macrophages and dendritic cells (DCs) during the early stage of airway allergies. IL‐27 exerts powerful modulatory influences on the cells of innate immunity [eg neutrophils, eosinophils, mast cells, monocytes, macrophages, dendritic cells (DCs), innate lymphoid cells (ILCs), natural killer (NK) cells and NKT cells)] and adaptive immunity (eg Th1, Th2, Th9, Th17, regulatory T, CD8+ cytotoxic T and B cells). The IL‐27‐mediated signalling pathways may be modulated to attenuate asthma and allergic rhinitis. In this review, a comprehensive discussion concerning the roles carried out by IL‐27 in asthma and allergic rhinitis was provided, while evidences are presented favouring the use of IL‐27 in the treatment of airway allergies.

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“…A role for less abundant T cell types in asthma is evolving (Table ). Both mouse and human studies have implicated invariant NKT cells (iNKT) in the pathogenesis of allergic asthma . These cells express T cell receptors (TCR) of limited diversity that recognize lipid antigens presented by the “non‐classical” MHC molecule, CD1d .…”

Section: T Cells and Severe Asthma: Current Conceptsmentioning

confidence: 99%

“…However, they comprise less than 2% of T cells in bronchoalveolar lavage (BAL) fluid from children with severe asthma . A similar cell type, mucosal‐associated invariant T (MAIT) cells, is abundant in the human lungs, and also displays limited TCR diversity . These cells respond to microbial‐derived vitamin B2 metabolites presented by the MHC class I‐related molecule MR1 and exert anti‐microbial effects by their cytotoxic activity and secretion of IFN‐γ and IL‐17 .…”

Section: T Cells and Severe Asthma: Current Conceptsmentioning

confidence: 99%

T cells in severe childhood asthma

Paul

Muehling

Eccles

et al. 2019

Clin Experimental Allergy

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Summary Severe asthma in children is a debilitating condition that accounts for a disproportionately large health and economic burden of asthma. Reasons for the lack of a response to standard anti‐inflammatory therapies remain enigmatic. Work in the last decade has shed new light on the heterogeneous nature of asthma, and the varied immunopathologies of severe disease, which are leading to new treatment approaches for the individual patient. However, most studies to date that explored the immune landscape of the inflamed lower airways have focused on adults. T cells are pivotal to the inception and persistence of inflammatory processes in the diseased lungs, despite a contemporary shift in focus to immune events at the epithelial barrier. This article outlines current knowledge on the types of T cells and related cell types that are implicated in severe asthma. The potential for environmental exposures and other inflammatory cues to condition the immune environment of the lung in early life to favour pathogenic T cells and steroid resistance is discussed. The contributions of T cells and their cytokines to inflammatory processes and treatment resistance are also considered, with an emphasis on new observations in children that argue against conventional type 1 and type 2 T cell paradigms. Finally, the ability for new technologies to revolutionize our understanding of T cells in severe childhood asthma, and to guide future treatment strategies that could mitigate this disease, is highlighted.

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Role of CD1d- and MR1-Restricted T Cells in Asthma

Cited by 26 publications

References 106 publications

Vitamin D and Immunological Patterns of Allergic Diseases in Children

Vitamin D and Immunological Patterns of Allergic Diseases in Children

The immunomodulatory potentials of interleukin‐27 in airway allergies

T cells in severe childhood asthma

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