Role of Catestatin in the Cardiovascular System and Metabolic Disorders

Zalewska, E.; Kmieć, Piotr; Sworczak, Krzysztof

doi:10.3389/fcvm.2022.909480

Cited by 21 publications

(19 citation statements)

References 112 publications

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“…Depending on the site of cleavage, CgA derived peptides can act both as vasoconstrictors or vasodilators, regulating blood pressure [ 21 , 22 ]. One such vasodilator is CST, a peptide which is also involved in the regulation of oxidative stress and chronic inflammation [ 23 , 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Reduction in CgA-Derived CST Protein Level in HTR-8/SVneo and BeWo Trophoblastic Cell Lines Caused by the Preeclamptic Environment

Bralewska

Pietrucha

Sakowicz

2023

IJMS

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One of the most dangerous complications of pregnancy is preeclampsia (PE), a disease associated with a high risk of maternal and fetal mortality and morbidity. Although its etiology remains unknown, the placenta is believed to be at the center of ongoing changes. One of the hormones produced by the placenta is chromogranin A (CgA). Thus far, its role in pregnancy and pregnancy-related disorders is enigmatic, yet it is known that both CgA and its derived peptide catestatin (CST) are involved in the majority of the processes that are disturbed in PE, such as blood pressure regulation or apoptosis. Therefore, in this study, the influence of the preeclamptic environment on the production of CgA using two cell lines, HTR-8/SVneo and BeWo, was investigated. Furthermore, the capacity of trophoblastic cells to secrete CST to the environment was tested, as well as the correlation between CST and apoptosis. This study provided the first evidence that CgA and CST proteins are produced by trophoblastic cell lines and that the PE environment has an impact on CST protein production. Furthermore, a strong negative correlation between CST protein level and apoptosis induction was found. Hence, both CgA and its derived peptide CST may play roles in the complex process of PE pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Reduction in CgA-Derived CST Protein Level in HTR-8/SVneo and BeWo Trophoblastic Cell Lines Caused by the Preeclamptic Environment

Bralewska

Pietrucha

Sakowicz

2023

IJMS

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“…In contrast, pancreastatin, another breakdown product of CgA, has increased levels in diabetic patients. When given exogenously to rodents, obese mice have reduced insulin sensitivity and increased inflammation [15][16][17][18] .…”

Section: Multivariate Logistic Regression Analysismentioning

confidence: 99%

Serum chromogranin A levels are associated with the SYNTAX score in coronary artery disease

Çelikkol

Demirkıran

Aydın

et al. 2023

Rev. Assoc. Med. Bras.

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pancreastatin, a dysglycemic peptide, 3. vasostatin-1, a vasodilator, antiadrenergic and antiangiogenic peptide, 4. serpinin, a proadrenergic peptide.Plasma Cts concentration is a predictor of hypertension. Previous studies have observed elevated serum CgA levels and reduced Cts processing in hypertension. Cts levels have been shown to decrease, while plasma CgA level increases. Metabolic and vascular effects of CgA have been investigated and their role in hypertension and coronary artery disease has been studied. CgA levels have also been found to increase in heart failure, acute myocardial infarction, old age, pulmonary hypertension, and inflammatory diseases [5][6][7][8] .We investigated the relationship between serum CgA levels and SYNTAX scores in patients with coronary artery disease. METHODS Study population and study designPatients who underwent coronary angiography from March 2020 to March 2021 for the diagnosis and treatment of coronary

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“…Представленные данные нашего обзора свидетельствуют в пользу того, что CST, вероятно, является надежным биомаркером активности симпатического отдела вегетативной нервной системы, а его высокие уровни у больных с ХСН отражают тяжесть патологического процесса. Однако, несмотря на достоверные результаты исследований, клиническая значимость оценки значений CST как отдельно, так и в рамках многомаркерной модели требует дальнейшего изучения в более крупных проспективных клинических исследованиях [60,61].…”

Section: заключениеunclassified

Catestanin – a promising biological marker for heart failure: A review

Alieva

Teplova²,

Reznik³

et al. 2022

Consilium Medicum

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The epidemic of heart failure (HF) is one of the problems that the global health system has been facing for decades. HF is a multicomponent clinical syndrome caused by dysfunction of the heart and its pathological remodeling. In addition to the well-known natriuretic peptides, a number of cardiovascular biological markers have now been identified that provide clinicians with additional opportunities in diagnosing, classifying, predicting, and monitoring the effectiveness of treating patients with HF. From the position of establishing the sympathetic load in patients with HF, it seems very promising to assess the concentrations of catestatin. The presented data of our literature review suggest that catestatin is probably a reliable biological marker of the activity of the sympathetic division of the autonomic nervous system, and its elevated concentrations in patients with HF reflect the severity of the pathological process. However, despite the reliable results of studies, the clinical significance of assessing the values of this marker both separately and in the framework of a multimarker model requires further study in larger prospective clinical studies.

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Role of Catestatin in the Cardiovascular System and Metabolic Disorders

Cited by 21 publications

References 112 publications

Reduction in CgA-Derived CST Protein Level in HTR-8/SVneo and BeWo Trophoblastic Cell Lines Caused by the Preeclamptic Environment

Reduction in CgA-Derived CST Protein Level in HTR-8/SVneo and BeWo Trophoblastic Cell Lines Caused by the Preeclamptic Environment

Serum chromogranin A levels are associated with the SYNTAX score in coronary artery disease

Catestanin – a promising biological marker for heart failure: A review

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