Role of Catecholamines and the Chemoreceptor Trigger Zone in Reserpine Induced Emesis

Bhargava, K. P.; Dixit, K. S.; Gupta, G.P.

doi:10.1111/j.1476-5381.1967.tb01936.x

British Journal of Pharmacology and Chemotherapy

1967

DOI: 10.1111/j.1476-5381.1967.tb01936.x

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Role of Catecholamines and the Chemoreceptor Trigger Zone in Reserpine Induced Emesis

K. P. Bhargava

K. S. Dixit

G.P. Gupta

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Cited by 3 publications

(1 citation statement)

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“…Several emetic agents-namely apomorphine (Wang & Borison, 1952), morphine, hydergine (Wang & Glaviano, 1954), emetine (Bhargava, Gupta & Chandra, 1961), reserpine (Bhargava, Dixit & Gupta, 1967), cardiac glycosides (Borison & Wang, 1951) and catecholamines (Borison, 1959)-are now known to act selectively on the CT-zone to evoke emesis. Histamine is particularly rich in the region of the area postrema which is the anatomical site of the emetic CT-zone (Adam, 1961).…”

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Role of the chemoreceptor trigger zone in histamine‐induced emesis

Bhargava

Dixit

1968

British J Pharmacology

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. In unanaesthetized dogs, the emetic action of histamine was studied after its injection into the cerebral venricles through chronically implanted cannulae in order to elucidate the role of the chemoreceptor trigger zone (CT‐zone), situated in the area postrema, for this emesis. . On injection into the lateral cerebral ventricle, about 10 times larger doses of histamine (3 mg) were required regularly to produce emesis, and it occurred after a longer latency than on injection into the fourth ventricle. This is in accord with an action of histamine on the CT‐zone. . After bilateral ablation of the CT‐zone, intraventricular injections of histamine no longer produced emesis even when injected in doses which were three to four times greater than those which regularly elicited vomiting in dogs with intact CT‐zone. The emesis produced in dogs by intraventricular injections of histamine is thus fully accounted for by an action on the CT‐zone. . Injections of chlorpromazine intramuscularly or of the two antihistamines cyclizine and mepyramine, either intramuscularly or into the lateral ventricle, prevented the emesis caused by histamine injected into the lateral ventricle. This protective action of the antihistamines—which did not extend to the emesis produced by oral copper sulphate—suggests the presence of histaminergic receptors in the CT‐zone.

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Role of the chemoreceptor trigger zone in histamine‐induced emesis

Bhargava

Dixit

1968

British J Pharmacology

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Role of the chemoreceptor trigger zone in cyclopropane induced emesis in dogs

Badola

Bhargava

Dixit

et al. 1971

British J Pharmacology

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Animal models in the study of vomiting

King¹

1990

Can. J. Physiol. Pharmacol.

101

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The emetic responses to various pharmacological agents, cytotoxins, and radiation are compared among animal species. The species included for comparison are the human, nonhuman primate, dog, cat, and ferret. The categories of pharmacologic compounds include both those compounds that act on identified membrane receptors (e.g., cholinergic agonists, catecholamines, and neuroactive peptides) and those that act on unidentified receptors (e.g., cardiac glycosides and Veratrum alkaloids, among others). Emphasis is placed on emetic dose-response relations and threshold ED50 and ED100 values calculated from these relations, as indices of species sensitivity to emetic stimuli. For the more noxious emetics, the cytotoxins and radiation, the latency to the first emetic episode and duration of emesis are also compared across species. The effect that peripheral and central nerve lesions have on species differences in emetic responses to stimuli is also discussed.

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Role of Catecholamines and the Chemoreceptor Trigger Zone in Reserpine Induced Emesis

Cited by 3 publications

References 11 publications

Role of the chemoreceptor trigger zone in histamine‐induced emesis

Role of the chemoreceptor trigger zone in histamine‐induced emesis

Role of the chemoreceptor trigger zone in cyclopropane induced emesis in dogs

Animal models in the study of vomiting

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