Role of carbon nano-materials in the analysis of biological materials by laser desorption/ionization-mass spectrometry

Najam‐ul‐Haq, Muhammad; Rainer, Matthias; Szabó, Zoltán; Vallant, Rainer M.; Huck, Christian W.; Bonn, Günther K.

doi:10.1016/j.jbbm.2006.11.004

Cited by 59 publications

(46 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A review describing the search for the perfect MALDI matrix has been published (Batoy et al, 2008) and Najam-ul-Haq et al (2007) have reviewed the use of carbon nano-materials as matrices. Erra-Balsells and Nonami (2008) have compared the relative performance of nor-harmane (1/35) with classical MALDI matrices.…”

Section: Matricesmentioning

confidence: 99%

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2007–2008

Harvey

2011

Mass Spectrometry Reviews

View full text Add to dashboard Cite

This review is the fifth update of the original review, published in 1999, on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2008. The first section of the review covers fundamental studies, fragmentation of carbohydrate ions, use of derivatives and new software developments for analysis of carbohydrate spectra. Among newer areas of method development are glycan arrays, MALDI imaging and the use of ion mobility spectrometry. The second section of the review discusses applications of MALDI MS to the analysis of different types of carbohydrate. Specific compound classes that are covered include carbohydrate polymers from plants, N- and O-linked glycans from glycoproteins, biopharmaceuticals, glycated proteins, glycolipids, glycosides and various other natural products. There is a short section on the use of MALDI mass spectrometry for the study of enzymes involved in glycan processing and a section on the use of MALDI MS to monitor products of the chemical synthesis of carbohydrates with emphasis on carbohydrate-protein complexes and glycodendrimers. Corresponding analyses by electrospray ionization now appear to outnumber those performed by MALDI and the amount of literature makes a comprehensive review on this technique impractical. However, most of the work relating to sample preparation and glycan synthesis is equally relevant to electrospray and, consequently, those proposing analyses by electrospray should also find material in this review of interest.

show abstract

Section: Matricesmentioning

confidence: 99%

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2007–2008

Harvey

2011

Mass Spectrometry Reviews

View full text Add to dashboard Cite

show abstract

“…Other types of nanostructures such as carbon nanotubes and mesoporous tungsten titanium oxide surfaces have been used for matrix-free LDI. Reviews of matrix-free MALDI approaches can be found in the literature (Cohen, Go, & Siuzdak, 2007;Najam-ul-Haq et al, 2007;Petterson, 2007).…”

Section: Matrix-free Approachesmentioning

confidence: 99%

“…This approach might also be used to produce new matrices for improved analysis of small molecule or to produce matrices that work particularly well for a certain interesting class of molecules. The position of MALDI as an analytical tool for small-molecule analysis will be strengthened by further improvements of matrixfree approaches (Cohen, Go, & Siuzdak, 2007;Najam-ul-Haq et al, 2007;Petterson, 2007).…”

Section: Future Directionsmentioning

confidence: 99%

Biomedical application of MALDI mass spectrometry for small‐molecule analysis

Kampen

Burgers

Groot

et al. 2010

Mass Spectrometry Reviews

136

101

View full text Add to dashboard Cite

Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) is an emerging analytical tool for the analysis of molecules with molar masses below 1,000 Da; that is, small molecules. This technique offers rapid analysis, high sensitivity, low sample consumption, a relative high tolerance towards salts and buffers, and the possibility to store sample on the target plate. The successful application of the technique is, however, hampered by low molecular weight (LMW) matrix-derived interference signals and by poor reproducibility of signal intensities during quantitative analyses. In this review, we focus on the biomedical application of MALDI-MS for the analysis of small molecules and discuss its favorable properties and its challenges as well as strategies to improve the performance of the technique. Furthermore, practical aspects and applications are presented.

show abstract

“…It is suggested that cobalt NPs take the advantages of a large surface area, high photoabsorption, and low heat capacity compared with those of microparticles. Inspired by Tanaka's results, a series of inorganic micro-and nanomaterials-such as graphite particles [9], gold NPs (AuNPs) [10], silver NPs [11], titanium dioxide NPs [12], silicon NPs [13], Au nanorods [14], and carbon nanotubes [15]-have been studied as potential inorganic matrices. Moreover, matrix-free LDI-MS has been proposed using porous silicon as a sample target for the analysis of small molecules such as peptides, drugs, surfactants, and carbohydrates [16].…”

mentioning

confidence: 99%

Gold nanoparticles as assisted matrices for the detection of biomolecules in a high-salt solution through laser desorption/ionization mass spectrometry

Lin

et al. 2009

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

Citrate-capped gold nanoparticles (AuNPs) serve as matrices for the determination of biomolecules in a high-salt solution through matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). In the case of using 2,5-dihydroxybenzoic acid (2,5-DHB) as a matrix, the signal intensities of neutral steroids were severely suppressed in a high-salt solution. A high concentration of NaCl caused the formation of the sodium adduct ions during the desorption/ionization process, resulting in a decrease of the signal intensities of the protonated ions. In comparison, by applying AuNP-assisted LDI-TOF-MS, the signal intensities of neutral steroids remained almost constant when the concentration of NaCl was increased to 500 mM. Because the use of citrate-capped AuNPs as matrices primarily offers alkali metal ion adducts, AuNP matrices have a higher tolerance to high NaCl concentrations relative to that of 2,5-DHB matrices. The relevant phenomena are also discovered in the case of analysis of neutral carbohydrate, monosialoganglioside, indolamine, and angiotensin I. The quantification of small molecules in a high-salt solution has been accomplished by AuNP-assisted LDI-TOF-MS coupled to a unique sample preparation, in which samples are deposited onto the sample plate before AuNPs. The present method has been further applied to the determination of urea, creatinine, uric acid, and glucose in a urine sample. (J Am Soc Mass Spectrom 2009, 20, 875-882)

show abstract

Role of carbon nano-materials in the analysis of biological materials by laser desorption/ionization-mass spectrometry

Cited by 59 publications

References 45 publications

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2007–2008

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2007–2008

Biomedical application of MALDI mass spectrometry for small‐molecule analysis

Gold nanoparticles as assisted matrices for the detection of biomolecules in a high-salt solution through laser desorption/ionization mass spectrometry

Contact Info

Product

Resources

About