Role of carbon-11 choline PET/CT in the management of uterine carcinoma: initial experience

Sofue, Keitaro; Tateishi, Ukihide; Sawada, Morio; Maeda, Takeyasu; Terauchi, Takashi; Kano, Daisuke; Inoue, Tomio; Sugimura, Kazuro

doi:10.1007/s12149-009-0230-z

Cited by 8 publications

(6 citation statements)

References 16 publications

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“…Thus, for detection of gynecologic malignancies 11 C-choline might be superior to 18 F-FDG and 18 F-FLT, which are excreted via the urinary tract, because of reduced masking of the pelvic region. 25,26 In this study, the clinical gold standard in PET oncology, 18 F-FDG, showed a markedly increased uptake into the tumor tissue of rabbits, whereas 18 F-FLT failed. However, 11 C-choline revealed an uptake comparable to 18 F-FDG, thus representing an alternative PET tracer to 18 F-FDG for imaging papillomavirus-induced tumors.…”

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confidence: 64%

“…35,36 Indeed 11 C-choline has been used successfully in PET imaging of tumors in the pelvic region, including cervical cancer. [22][23][24]26,37,38 Therefore, the simultaneous use of noninvasive, high-tissue contrast MR imaging in combination with 11 C-choline PET has the potential to improve diagnosis and support future clinical staging of cancers. In addition, we confirmed reports from previous studies demonstrating that the uptake of 11 C-choline into tumors was lower than the uptake of 18 F-FDG.…”

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Evaluation of Positron Emission Tomographic Tracers for Imaging of Papillomavirus-Induced Tumors in Rabbits

et al. 2014

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In this study, simultaneous positron emission tomography (PET)/magnetic resonance (MR) imaging was employed to evaluate the feasibility of the PET tracers 2-deoxy-2-18F-fluoro-d-glucose (18F-FDG), 11C-choline, and 18F-fluorothymidine (18F-FLT) to detect papillomavirus-induced tumors in an established rabbit model system. The combined PET/MR allowed the analysis of tracer uptake of the tumors using the morphologic information acquired by MR. New Zealand White rabbits were infected with cottontail rabbit papillomavirus genomes and were imaged for up to 10 months with a simultaneous PET/MR system during the course of infection. The uptake characteristics of the PET tracers 11C-choline and 18F-FLT of tumors and reference tissues were examined relative to the clinical standard, 18F-FDG. Tracer biodistribution of various organs was measured by gamma-counting after the last PET scan and compared to the in vivo PET/MR 18F-FDG uptake. Increased tracer uptake was found 2 months postinfection in primary tumors with 18F-FDG and 11C-choline, whereas 18F-FLT failed to detect the tumors at all measured time points. Our data show that the PET tracer 18F-FDG is superior for imaging papillomavirus-induced tumors in rabbits compared to 11C-choline and 18F-FLT. However, 11C-choline imaging, which has previously been applied to detect various tumor entities in patients, appears to be an alternative to 18F-FDG.

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confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Evaluation of Positron Emission Tomographic Tracers for Imaging of Papillomavirus-Induced Tumors in Rabbits

et al. 2014

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“…They found that carbon-11 choline PET/CT was good for tumor, nodal and metastatic saging, as well as SUV reduction was remarkable in five patients after receiving treatment. [100] FDG-PET has been evaluated for treatment planning in cervical cancer patients. Grigsby et al evaluated patients with cervical cancer and negative lymph nodes diagnosed by FDG-PET.…”

Section: Cervical Cancermentioning

confidence: 99%

Clinical applications of positron emission tomography-computed tomography in oncology

2010

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Positron emission computed tomography (PET) is a functional diagnostic imaging technique, which can accurately measure in vivo distribution of a variety of radiopharmaceuticals. The ability of PET to study various biological processes (glucose, amino acid, phospholipids, receptors etc.) opens up new possibilities for both day-to-day clinical use and research applications in the practice of oncology. Addition of CT to PET has resulted in better specificity and sensitivity than either of the modalities alone, as the combined approach has the ability to demonstrate functional and structural details in the same setting. F-18 fluoro-2-deoxy-D-glucose (FDG), an analogue of glucose, is the most commonly used radiotracer in PET-CT imaging. The F-18 FDG uptake in tumor cells is directly proportional to glucose metabolism in the cells. Since glucose metabolism is increased several folds in the malignant tumors, PET-CT images show preferential higher FDG uptake in malignant cells as compared to normal cells. F-18 FDG PET-CT has been found to be useful in the initial staging, detection of recurrent disease and monitoring the response to the therapy in malignancies including lung cancer, colorectal cancer, lymphoma, melanoma, esophageal cancer, head and neck cancer, breast cancer.

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“…In cell line studies of endometrial cancer, the expression and activity of choline kinase alpha is increased with a several-fold increase in the uptake of 3 H choline in endometrial cancer cells compared to normal endometrial stromal cells (19). Early pilot studies of 11 C choline in gynecological cancer show promise (20,21), however 18 F-labelled fluoro-methyl and fluoroethyl choline have a longer radioactive half-life (110 minutes) and are therefore more practical to use. The use of Fluoro-ethyl-choline (FEC)-PET/CT in detecting nodal metastases in endometrial and cervical cancer has not been previously explored.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of FEC-PET/CT, FDG-PET/CT, and Diffusion-Weighted MRI in Detection of Nodal Metastases in Surgically Treated Endometrial and Cervical Carcinoma

Rockall

Barwick

Wilson

et al. 2021

Clinical Cancer Research

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Nodal status is a highly important prognostic factor in endometrial and cervical cancers and has a significant impact on patient risk stratification and management. This is the first multicentre prospective study to directly compare the diagnostic performance of FEC-PET/CT, FDG-PET/CT and DW-MRI for the detection of nodal involvement in surgically staged endometrial and cervical cancers, with a strict histological reference standard.No technique had sufficient sensitivity to obviate the need for surgical nodal staging in radiologically node negative patients, in cases where nodal staging is considered appropriate. However, the low false positive rate may contribute to patient risk stratification in cases with difficult surgical decision making, for arbitration in borderline surgical cases: In cervical cancer, a FDG-positive case could support a decision to redirect patients from radical surgery to chemoradiotherapy options. In endometrial cancer, a FDG-positive case could allow planning of a more tailored therapeutic approach. By identifying the site and extent of avid nodes, a targeted surgical dissection of the area of interest could be planned avoiding morbidity from unnecessary radicality. Moreover, a preoperative discussion with the patient about her systemic and radiotherapeutic options and how those would complement any surgical approach, would be facilitated.

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Role of carbon-11 choline PET/CT in the management of uterine carcinoma: initial experience

Abstract: (11)C-choline PET/CT is an accurate means for the management of patients with uterine carcinoma. The combination of (11)C-choline PET/CT and MRI increases the accuracy of staging in patients with uterine carcinoma.

Cited by 8 publications

References 16 publications

Evaluation of Positron Emission Tomographic Tracers for Imaging of Papillomavirus-Induced Tumors in Rabbits

Evaluation of Positron Emission Tomographic Tracers for Imaging of Papillomavirus-Induced Tumors in Rabbits

Clinical applications of positron emission tomography-computed tomography in oncology

Diagnostic Accuracy of FEC-PET/CT, FDG-PET/CT, and Diffusion-Weighted MRI in Detection of Nodal Metastases in Surgically Treated Endometrial and Cervical Carcinoma

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