2019
DOI: 10.1155/2019/3515026
|View full text |Cite
|
Sign up to set email alerts
|

Role of Calprotectin as a Biomarker in Periodontal Disease

Abstract: Periodontal disease (PD) is a common infectious and inflammatory disease characterised by inflammation of tissues surrounding and supporting the teeth and destruction of the associated alveolar bone, eventually resulting in tooth loss. This disease is caused by periodontopathic bacteria in plaque biofilm and resultant innate and adaptive immune responses in periodontal tissues. Calprotectin (CLP) is a calcium-binding protein of the S-100 protein family and is found to be induced by activated granulocytes, mono… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

1
20
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 23 publications
(25 citation statements)
references
References 95 publications
1
20
0
Order By: Relevance
“…Several studies shed light on the key role of calprotectin and its subunits in the pathobiology of a number of inflammatory conditions including periodontal diseases [49,81,82]. In addition the GCF calprotectin levels were positively correlated with clinical parameters of periodontitis [81]. Specifically, in our comparative study, we detected the acetylated form (m/z = 13153) and the acetylated and glutathionylated form of the S100-A9 (m/z = 13458) [24].…”
Section: The Gcf Antimicrobial Peptidomesupporting
confidence: 49%
See 3 more Smart Citations
“…Several studies shed light on the key role of calprotectin and its subunits in the pathobiology of a number of inflammatory conditions including periodontal diseases [49,81,82]. In addition the GCF calprotectin levels were positively correlated with clinical parameters of periodontitis [81]. Specifically, in our comparative study, we detected the acetylated form (m/z = 13153) and the acetylated and glutathionylated form of the S100-A9 (m/z = 13458) [24].…”
Section: The Gcf Antimicrobial Peptidomesupporting
confidence: 49%
“…Our group detected two proteoforms of S100-A9 with m/z = 13,153 and 13,458 and the oxidized forms of S100-A8 [23,24]. S100-A9 together with S100 A8 belong to the damage-associated molecular pattern family members of danger signals that initiate and amplify local inflammation and innate immune responses [81]. S100-A9 is frequently associated with S100-A8 to form the S100-A8/S100-A9 heterodimer, known as calprotectin, with anti-microbial, chemotactic, pro-apoptotic and anti-proliferative activities [81].…”
Section: The Gcf Antimicrobial Peptidomementioning
confidence: 90%
See 2 more Smart Citations
“…S100A8 and S100A9 can form homodimers in vivo, but they are primarily a 1:1 non‐covalent heterodimers. Other binding forms of S100A8 and S100A9 may also occur at the presence of Ca 2+ , such as trimer (S100A8) 2 (S100A9) or tetramer (S100A8) 2 (S100A9) 2 11 . Calprotectin has a broad regulatory effect on immune‐inflammatory responses.…”
Section: Introductionmentioning
confidence: 99%