Role of Calcium-Phosphorus Metabolism in the Pathogenesis of Stable Coronary Artery Disease in Patients With Obesity

Calcium-phosphorus relationships in the combined course of stable ischemic heart disease in patients with obesity

“…According to the European Association of Cardiologists, coronary heart disease (CHD) accounts for about 7.5 million deaths per year and in almost 75 %, lethal cases of stable coronary heart disease (SCHD) are registered in low-and middle-income countries [1,2]. Although successful methods of diagnosis and treatment of various forms of SCHD have been developed so far, the lack of confirmation of a single theory of atherosclerosis, immature system of preventive measures and comorbid disease, does not significantly reduce the number of patients with SCHD.…”

“…Although successful methods of diagnosis and treatment of various forms of SCHD have been developed so far, the lack of confirmation of a single theory of atherosclerosis, immature system of preventive measures and comorbid disease, does not significantly reduce the number of patients with SCHD. Besides, no less significant problem of modern society is obesity, which is rightly called the non-infectious epidemic of the 21 st century [2]. According to the WHO statistics, the number of obese people has more than tripled since 1975 [3,5,6].…”

“…According to the WHO statistics, the number of obese people has more than tripled since 1975 [3,5,6]. It has been established that among the adult population of Europe, obesity is the cause of SCHD in 35 % of cases [2,4].…”

“…Comorbid pathology, namely, atherosclerosis as an etiological factor in development of coro-nary heart disease and obesity, leads to negative consequences, characterized by development of complications, among which there is the frequency and medical and social significance of structural and functional disorders of bone architecture [2][3][4]. But one of the positive aspects of obesity is considered to be its protective effect on development of osteoporosis (OP) [2]. This fact is denied in some scientific papers, but a number of clinical studies have shown a link between the degree of obesity, the manifestations of atherosclerosis and bone mineral density (BMD) [6].…”

“…There is an assumption that a certain similarity between the mechanisms of OP development and atherosclerosis is due to the processes that take place with the participation of mononuclear cells [2]. This structural unit in atherosclerosis is differentiated in the vascular wall into macrophagelike "foamy" cells, and in OP -in osteoclasts [5,8,9].…”