Role of calcium oscillations in sperm physiology

Mata-Martínez, Esperanza; Sánchez-Cárdenas, Claudia; Chávez, Julio C.; Guerrero, Adán; Treviño, Claudia L.; Corkidi, Gabriel; Montoya, Fernando; Hernández‐Herrera, Paul; Buffone, Mariano G.; Balestrini, Paula A.; Darszon, Alberto

doi:10.1016/j.biosystems.2021.104524

Cited by 20 publications

(11 citation statements)

References 169 publications

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“…The evolution and adaptation of such systems in the presence of periodic stimuli require internal reconfiguration of their dynamic networks to cope with the environmental challenges associated with these periodic signals. For instance, calcium oscillations in the extracellular medium trigger essential functions of the sperm cell to fertilize the egg [44]. Immune T cells can selectively filter out the frequency of external periodic signals to trigger different inflammatory responses [17,45].…”

Section: Discussionmentioning

confidence: 99%

Resonant learning in scale-free networks

2023

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Large networks of interconnected components, such as genes or machines, can coordinate complex behavioral dynamics. One outstanding question has been to identify the design principles that allow such networks to learn new behaviors. Here, we use Boolean networks as prototypes to demonstrate how periodic activation of network hubs provides a network-level advantage in evolutionary learning. Surprisingly, we find that a network can simultaneously learn distinct target functions upon distinct hub oscillations. We term this emergent property resonant learning, as the new selected dynamical behaviors depend on the choice of the period of the hub oscillations. Furthermore, this procedure accelerates the learning of new behaviors by an order of magnitude faster than without oscillations. While it is well-established that modular network architecture can be selected through evolutionary learning to produce different network behaviors, forced hub oscillations emerge as an alternative evolutionary learning strategy for which network modularity is not necessarily required.

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Section: Discussionmentioning

confidence: 99%

Resonant learning in scale-free networks

2023

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“…In mammals, sperm fusion and Ca 2+ oscillation promote complete development of fertilized oocytes [ 19 , 20 ]. Specific sperm-derived factors are believed to induce Ca 2+ oscillation.…”

Section: Discussionmentioning

confidence: 99%

Sodium Hexametaphosphate Serves as an Inducer of Calcium Signaling

et al. 2023

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In bacteria, polymers of inorganic phosphates, particularly linear polyphosphate, are used as alternative phosphate donors for adenosine triphosphate production. A six-chain form of sodium metaphosphate, sodium hexametaphosphate (SHMP), is believed to have no physiological functions in mammalian cells. In this study, we explored the possible effects of SHMP on mammalian cells, using mouse oocytes, which are useful for observing various spatiotemporal intracellular changes. Fertilization-competent oocytes were isolated from the oviducts of superovulated mice and cultured in an SHMP-containing medium. In the absence of co-incubation with sperm, SHMP-treated oocytes frequently formed pronuclei and developed into two-cell embryos owing to the increase in calcium concentration in the cytoplasm. We discovered an intriguing role for SHMP as an initiator of calcium rise in mouse oocytes, presumably in a wide variety of mammalian cells.

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“…The level of ATP2A2 / SERCA2 of sperm may related the calcium flex. Intracellular calcium is a key regulator of the sperm physiology, including sperm maturation, sperm motility, capacitation and acrosome reaction [ 25 , 26 ]. In present study, we have identified ATP2A2 as a functional target gene of miR-6531 by targeting its CDS region in bovine Leydig cell.…”

Section: Discussionmentioning

confidence: 99%

Bta-miR-6531 Regulates Calcium Influx in Bovine Leydig Cells and Is Associated with Sperm Motility

Ding

Xia

et al. 2022

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MicroRNAs (miRNAs) play key roles in sperm as the regulatory factors involved in fertility and subsequent early embryonic development. Bta-miR-6531 is specifically a highly enriched miRNA in low-motility sperms in previous study. To investigate the mechanism of bta-miR-6531, 508 shared target genes of bta-miR-6531 were predicted using two miRNA target databases (TargetScan7 and miRWalk). According to the Kyoto Encyclopedia of Genes and Genomes (KEGG), the calcium and cAMP signaling pathways were the most enriched of the target genes. A dual-luciferase assay indicated that bta-miR-6531 targeted ATP2A2 mRNA by binding to the coding sequence region. In bovine Leydig cells, bta-miR-6531 overexpression affected the intracellular calcium concentration by restraining ATP2A2 expression. Moreover, we observed high calcium concentrations and high ATP2A2 protein levels in high-motility sperm compared with those in low-motility sperms. Furthermore, high-linkage single-nucleotide polymorphisms (SNPs) of the pre-bta-miR-6531 sequence were identified that related to sperm traits. Genotype TCTC of bta-miR-6531 showed high sperm motility and density and low deformity rate in Holstein bulls. However, the mutation in pre-miR-6531 did not significantly affect mature bta-miR-6531 expression in the sperm or cell models. Our results demonstrate that bta-miR-6531 might involve in sperm motility regulation by targeting ATP2A2 of the calcium signaling pathway in bovine spermatozoa.

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Role of calcium oscillations in sperm physiology

Cited by 20 publications

References 169 publications

Resonant learning in scale-free networks

Resonant learning in scale-free networks

Sodium Hexametaphosphate Serves as an Inducer of Calcium Signaling

Bta-miR-6531 Regulates Calcium Influx in Bovine Leydig Cells and Is Associated with Sperm Motility

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