Role of calcium integrin‐binding protein 1 in the mechanobiology of the liver endothelium
Cong Wang,
Eric Felli,
Sonia Selicean
et al.
Abstract:Liver sinusoidal endothelial cells (LSECs) dysfunction is a key process in the development of chronic liver disease (CLD). Progressive scarring increases liver stiffness in a winch‐like loop stimulating a dysfunctional liver cell phenotype. Cellular stretching is supported by biomechanically modulated molecular factors (BMMFs) that can translocate into the cytoplasm to support mechanotransduction through cytoskeleton remodeling and gene transcription. Currently, the molecular mechanisms of stiffness‐induced LS… Show more
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