Role of c-Myb in the regulation of natural killer cell activity

Shin, Hee-Wook; Lee, Yoojin; Kim, Jongsun

doi:10.1016/j.bbrc.2018.08.044

Cited by 2 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such mutations occur in many cancers, but are especially common in melanoma for BRAF [102] and head and neck, bladder, and thyroid cancers for HRAS [103]. c-MYB is a transcription factor that controls expression of genes involved in hematopoiesis and colonic crypt formation, and may also play a role in tumor immune surveillance in natural killer cells [104,105]. Oncogenic mutations within c-MYB are associated with multiple cancer types including pancreatic, colon, prostate, and liver cancers [106].…”

Section: I-motifs In Oncogenesmentioning

confidence: 99%

The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure

Brown

Kendrick

2021

Pharmaceuticals

View full text Add to dashboard Cite

Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-motif. When within promoter regions, the i-motif has the potential to act as a molecular switch for controlling gene expression. However, i-motif structures in genomic areas of repetitive nucleotide sequences may play a role in facilitating or hindering expansion of these DNA elements. Despite research on the i-motif trailing behind the complementary G-quadruplex structure, recent discoveries including the identification of a specific i-motif antibody are pushing this field forward. This perspective reviews initial and current work characterizing the i-motif and providing insight into the biological function of this DNA structure, with a focus on how the i-motif can serve as a molecular target for developing new therapeutic approaches to modulate gene expression and extension of repetitive DNA.

show abstract

Section: I-motifs In Oncogenesmentioning

confidence: 99%

The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure

Brown

Kendrick

2021

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

Resveratrol Activates Natural Killer Cells through Akt- and mTORC2-Mediated c-Myb Upregulation

Lee

Kim

2020

IJMS

Self Cite

View full text Add to dashboard Cite

Natural killer (NK) cells are suitable targets for cancer immunotherapy owing to their potent cytotoxic activity. To maximize the therapeutic efficacy of cancer immunotherapy, adjuvants need to be identified. Resveratrol is a well-studied polyphenol with various potential health benefits, including antitumor effects. We previously found that resveratrol is an NK cell booster, suggesting that it can serve as an adjuvant for cancer immunotherapy. However, the molecular mechanism underlying the activation of NK cells by resveratrol remains unclear. The present study aimed to determine this mechanism. To this end, we investigated relevant pathways in NK cells using Western blot, real-time polymerase chain reaction, pathway inhibitor, protein/DNA array, and cytotoxicity analyses. We confirmed the synergistic effects of resveratrol and interleukin (IL)-2 on enhancing the cytolytic activity of NK cells. Resveratrol activated Akt by regulating Mammalian Target of Rapamycin (mTOR) Complex 2 (mTORC2) via phosphatase and tensin homolog (PTEN) and ribosomal protein S6 kinase beta-1 (S6K1). Moreover, resveratrol-mediated NK cell activation was more dependent on the mTOR pathway than the Akt pathway. Importantly, resveratrol increased the expression of c-Myb, a downstream transcription factor of Akt and mTORC2. Moreover, c-Myb was essential for resveratrol-induced NK cell activation in combination with IL-2. Our results demonstrate that resveratrol activates NK cells through Akt- and mTORC2-mediated c-Myb upregulation.

show abstract

Role of c-Myb in the regulation of natural killer cell activity

Cited by 2 publications

References 25 publications

The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure

The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure

Resveratrol Activates Natural Killer Cells through Akt- and mTORC2-Mediated c-Myb Upregulation

Contact Info

Product

Resources

About