Role of bronchus morphology on mucus mobilization during chest physiotherapy

Mauroy, Benjamin; Fausser, Christian; Pelca, Dominique; Merckx, Jacques; Flaud, Patrice

doi:10.1183/13993003.congress-2015.pa4204

Cited by 2 publications

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“…Also, our airways remain perfectly cylindrical whatever their transmural pressure. The typical star shape of the lumen of a constricted airway is not accounted for [10]. A total collapse of the airways is also not possible in our model since the air flow rate is constrained.…”

Section: Discussionmentioning

confidence: 99%

Wall shear stress distribution in a compliant airway tree

Stéphano,

Mauroy

2020

Preprint

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In the lung, the walls of the bronchi are protected by a mucus layer that is constantly renewed and motioned toward the oesopharyngeal region. Its role is to capture the inhaled particles and to remove them from the lung. The mucus layer is submitted to a shear stress by the air flow in the bronchi. The conditions under which it induces a displacement of the mucus, such as during cough, are still not clearly established. Nevertheless, the air-mucus interaction justifies several common chest physiotherapy technics used to help the draining of the mucus in prevalent diseases such as asthma, bronchiolitis or cystic fibrosis. Hence, understanding how the wall shear stress distributes in the lung could bring interesting highlights on these therapies.Hence, we develop a mathematical model to study the distribution of the wall shear stress induced by an outgoing air flow in an airway tree. This model accounts for the main physical processes that determines the wall shear stresses, more particularly the compliance of the airways and the air inertia. We show that the wall shear stress exhibits a maximum within the tree whose amplitude and location depend on the amount of air flow and on the "tissue" pressure surrounding the airways. Our analysis suggests that a tuning of the air flow and tissue pressure might allow to control, at least partially, the air-mucus interaction in the lung.

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Section: Discussionmentioning

confidence: 99%

Wall shear stress distribution in a compliant airway tree

Stéphano,

Mauroy

2020

Preprint

Self Cite

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Wall shear stress distribution in a compliant airway tree

Stéphano

Mauroy

2021

Physics of Fluids

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The airflow in the bronchi applies a shear stress on the bronchial mucus, which can move the mucus. The air–mucus interaction plays an important role in cough and in chest physiotherapy (CP). The conditions under which it induces a displacement of the mucus are still unclear. Yet, the air–mucus interaction justifies common technics of CP used to help the draining of the mucus in prevalent diseases. Hence, the determination of the distribution of the shear stress in the lung is crucial for understanding the effects of these therapies and, potentially, improves their efficiency. We develop a mathematical model to study the distribution of the wall shear stress (WSS) induced by an air flow exiting an airway tree. This model accounts for the main physical processes that determine the WSS, more particularly the compliance of the airways, the air inertia, and the tree structure. We show that the WSS distribution in the tree depends on the dynamics of the airways deformation and on the air inertia. The WSS distribution in the tree exhibits a maximum whose amplitude and location depend on the amount of air flow and on the “tissue” pressure surrounding the airways. To characterize the behavior of the WSS at the tree bifurcations, we derive new analytical criteria related to the airway size reduction in the bifurcations. Our results suggest that a tuning of the airflow and of the tissue pressure during a CP maneuver might allow to control, at least partially, the air–mucus interaction in the lung.

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Role of bronchus morphology on mucus mobilization during chest physiotherapy

Cited by 2 publications

References 0 publications

Wall shear stress distribution in a compliant airway tree

Wall shear stress distribution in a compliant airway tree

Wall shear stress distribution in a compliant airway tree

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