Role of bromelain in the treatment of patients with pityriasis lichenoides chronica

Risulo, Massimiliano; Rubegni, Pietro; Sbano, Paolo; Poggiali, S; Fimiani, Michele

doi:10.1080/09546630701299147

Cited by 22 publications

(16 citation statements)

References 18 publications

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“…Systemic antibiotics, including tetracycline and erythromycin, have been used for their anti‐inflammatory rather than antibiotic effects . Severe or refractory cases of PL require additional systemic therapies, such as corticosteroids, methotrexate, acitretin, cyclosporine, and bromelain . To date, the efficacy of combination therapies utilizing NB‐UVB phototherapy and systemic medications has not been reported.…”

Section: Discussionmentioning

confidence: 99%

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Is narrowband ultraviolet B monotherapy effective in the treatment of pityriasis lichenoides?

et al. 2013

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Section: Discussionmentioning

confidence: 99%

“…Several studies have evaluated the efficacy of the different therapeutic modalities implemented in the treatment of PL . However, studies comparing the efficacy and safety of phototherapy in combination with systemic medications are limited.…”

Section: Discussionmentioning

confidence: 99%

Is narrowband ultraviolet B monotherapy effective in the treatment of pityriasis lichenoides?

et al. 2013

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“…After treatment all the victims of PLC were fully recovered with zero side effects which is a virtue of its immuno-modulatory and antiviral trait (Massimiliano et al 2007). …”

Section: Dermatological Disorders Pityriasislichenoideschronica (Plc)mentioning

confidence: 99%

Bromelain: Methods of Extraction, Purification and Therapeutic Applications

Manzoor

Nawaz

Mukhtar

et al. 2016

Braz. arch. biol. technol.

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“…Kod ostalih šest pacijenata, bolest se nije vratila ni posle 12 meseci. Ove efekte bromelaina treba potvrditi u daljim ispitivanjima (22).…”

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Current experience and future perspectives of bromelain application in medicine

Milić¹,

Milanović²,

Goločorbin-Kon³

et al. 2014

Medicinski casopis

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Bromelain je sirov, vodeni ekstrakt stabljike i ploda ananasa (Ananas cosmus fam. Bromeliaceae) i predstavlja kompleksnu mešavinu različitih tiol endopeptidaza, raznovrsnih glikoliziranih enzimskih vrsta papainske superfamilije enzima koji imaju različitu proteolitičku aktivnost (1, 2). dobija se iz hladnog soka ananasa centrifugiranjem, ultrafiltracijom, liofilizacijom i drugim postupcima. Smatra se da je bromelain glikoprotein sastavljen od jednog polipeptidnog i jednog bočnog oligosaharidnog lanca koji je vezan za asparagin. Oligosaharidni lanac sadrži monosaharide: d-glukozamin, d-manozu, d-ksilozu i l-fukozu u odnosu 2 : 2 : 1 : 1. Polipeptidni lanac je sastavljen od 211 (2) rezidua i sadrži 15 lizinskih ostataka (3, 4). Bromelain ima izuzetnu termičku stabilnost i zadržava svoju proteolitičku aktivnost na temperaturi između 40 °C i 60 °C na kojoj većina enzima postaje neaktivna ili se denaturiše, a stabilan je pri pH vrednosti u rasponu od 5 do 10 (5). američka agencija za hranu i lekove (Fda) svrstava ga na listu bezbednih supstanci koje se koriste u prehrambenoj industiji kao aditiv za omekšavanje mesa. Komercijalno dostupni proizvodi uglavnom sadrže bromelain iz stabljike u obliku praška, krema, tableta ili kapsula. danas se na tržištu nalaze preparati koji kombinuju bromelain s drugim prirodnim sastojcima, kao što su Phlogenzym ® , Wobenzym ® , BCQ ® , a postoje i preparati u kojima se bromelain nalazi samostalno npr. ananase ® , Bromelain-POS ® i slično (6).Doziranje. Bromelain je bezbedan za primenu u terapijskim dozama 200-2000 mg (500-5000 FiP) dnevno tokom dužeg perioda. utvrđena je terapijska efikasnost i u dozama 120-160 mg/dnevno. Najbolji rezultati postižu se

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Role of bromelain in the treatment of patients with pityriasis lichenoides chronica

Abstract: In conclusion bromelain can be considered an effective therapeutic option for PLC; its efficacy could be related to its anti-inflammatory, immunomodulatory and/or anti-viral properties.

Cited by 22 publications

References 18 publications

Is narrowband ultraviolet B monotherapy effective in the treatment of pityriasis lichenoides?

Is narrowband ultraviolet B monotherapy effective in the treatment of pityriasis lichenoides?

Bromelain: Methods of Extraction, Purification and Therapeutic Applications

Current experience and future perspectives of bromelain application in medicine

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