Role of Brain-Derived Neurotrophic Factor (Bdnf) in the Diagnosis of Cogntive Dysfunction in Patients With Type 2 Diabetes

Gatskikh, I.V.; Veselova, O.F.; Петрова, М. М.; Шалда, Т. П.; Adamyan, Ripsime Ashotovna; Kalashnikova, Kseniya Mikhaylovna

doi:10.12731/wsd-2016-1-10-23

V Mire Nauchnykh Otkrytiy

2016

DOI: 10.12731/wsd-2016-1-10-23

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Role of Brain-Derived Neurotrophic Factor (Bdnf) in the Diagnosis of Cogntive Dysfunction in Patients With Type 2 Diabetes

I.V. Gatskikh¹,

O.F. Veselova²,

М. М. Петрова³

et al.

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2019

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“…In the adult organism, it performs the function of a neuroprotector, protecting nerve cells from ischemia, and also ensures the normal functioning of neurons and their interaction with each other. A decrease in the concentration of BDNF in the blood indicates damage to the nervous tissue [7].…”

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confidence: 99%

Laboratory Indicators of Diabetic Polyneuropathy

Степанова

Popyhova

Попыхова³

et al. 2019

Medical academic journal

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Центральная научно-исследовательская лаборатория ФГБОУ ВО «Саратовский государственный медицинский университет им. В.И. Разумовского» Минздрава России, СаратовThis study is devoted to diabetic polyneuropathy (DPN) -one of the common complications of diabetes mellitus (DM). The possibilities of laboratory diagnosis of this condition are shown. The purpose of this study was to examine the pathogenetic and diagnostic significance of certain neurospecific proteins and cytokines in DPN. The analysis of the literature data on the possibility of using neurospecific proteins and some cytokines in patients with diabetes as markers of neural tissue damage has been carried out.Работа посвящена диабетической полинейропатии (ДПН) -одному из распространенных осложнений сахарного диабета (СД). Показаны возможности лабораторной диагностики данного состояния. Целью настоящей работы являлось рассмотрение патогенетической и диагностической значимости некоторых нейроспецифических белков и цитокинов при ДПН. Проведен анализ литературных данных о возможности использования у пациентов с СД в качестве маркеров повреждения невной ткани нейроспецифических белков и некоторых цитокинов.Ключевые слова: диабетическая полинейропатия; нейроспецифические белки; цитокины.

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mentioning

confidence: 99%

Laboratory Indicators of Diabetic Polyneuropathy

Степанова

Popyhova

Попыхова³

et al. 2019

Medical academic journal

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Cognitive Disability in Estrogenectomited and Old Rats With Development of Diabetes Mellitus

et al. 2019

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Introduction: In recent years, there have been many works devoted to the study of the effects of sex hormones on cognitive function. Clinical studies have found that in menopausal women, the tendency to develop type 2 diabetes will increase, the spatial and short-term working memory worsens, and there is a tendency to develop depression. The findings suggest that estrogens are involved in the mechanisms of insulin resistance in tissues, in the synthesis of mediators in the catecholaminergic systems of the brain, but many questions remain unresolved. The aim: Therefore, the aim of our study was to establish the effect of estrogens on the indices of spatial memory in ovariectomized and old rats against the background of the development of experimental diabetes. Materials and methods: The study was conducted on 30 adult rats females 4-5 months and 20 months. The study groups were ovariectomized and reproduced experimental type 2 diabetes mellitus with protamine sulfate. The study of spatial memory was carried out in an eight-sleeved radial labyrinth. Results and conclusions: Ovariectomy caused the deterioration of spatial memory relative to the living control group, and diabetes mellitus aggravated pathological changes. The changes that occur after ovariectomy suggest estrogen involvement in the regulation of cognitive functions.

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Role of Brain-Derived Neurotrophic Factor (Bdnf) in the Diagnosis of Cogntive Dysfunction in Patients With Type 2 Diabetes

Cited by 2 publications

References 0 publications

Laboratory Indicators of Diabetic Polyneuropathy

Laboratory Indicators of Diabetic Polyneuropathy

Cognitive Disability in Estrogenectomited and Old Rats With Development of Diabetes Mellitus

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