Role of Bovine Placental Lactogen in Intercellular Signalling during Mammary Growth and Lactation

Collier, Robert J.; Byatt, John C.; McGrath, Michael; Eppard, P.J.

doi:10.1007/978-1-4615-1973-7_2

Intercellular Signalling in the Mammary Gland 1995

DOI: 10.1007/978-1-4615-1973-7_2

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Role of Bovine Placental Lactogen in Intercellular Signalling during Mammary Growth and Lactation

Robert J. Collier

John C. Byatt

Michael McGrath

et al.

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Cited by 3 publications

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Insulin-like growth factors in milk and mammary gland

Prosser

1996

J Mammary Gland Biol Neoplasia

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Milk contains insulin-like growth factor I and II (IGF-I and IGF-II) and four IGF binding proteins (IGFBP). Their concentrations are highest prepartum and early postpartum, coinciding with maximal proliferation of mammary cells and the time when the infant gut is the least developed. This has lead to the suggestion that IGFs may be important for the growth and development of the mammary gland and that IGFs in milk play a role in promoting development of the gastrointestinal tract of the newborn. IGF-I and, to a lesser extent, IGF-II can stimulate milk yield and blood flow in goats when infused directly into the mammary gland, suggesting they may also be important in supporting established lactation. Thus IGFs may have a dual function in the mammary gland, establishing and maintaining the maternal mammary system and, once secreted into milk, supporting gastrointestinal development in the newborn.

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Insulin-like growth factors in milk and mammary gland

Prosser

1996

J Mammary Gland Biol Neoplasia

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Animal models for the study of milk secretion

Wilde¹,

Hurley²

1996

J Mammary Gland Biol Neoplasia

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Milk secretion is regulated by a complex interaction of galactopoietic hormones which is not yet fully understood. Recent studies have demonstrated that this systemic control is modulated within the mammary gland by local mechanisms responsive to the frequency and completeness of milk removal. New insights into the endocrine and local (paracrine and autocrine) regulation of milk secretion have come from the adaptation of traditional endocrinological techniques to take advantage of new molecular tools, and from technical advances in other fields. This paper reviews recently developed animal models for the study of milk secretion and describes their application to provide new information into the roles of two key galactopoietic hormones, growth hormone and prolactin, and the modulation of their actions by local, intramammary mechanisms.

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Biologie de la lactation

Houdebine¹

2007

EMC - Obstétrique

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Role of Bovine Placental Lactogen in Intercellular Signalling during Mammary Growth and Lactation

Cited by 3 publications

References 47 publications

Insulin-like growth factors in milk and mammary gland

Insulin-like growth factors in milk and mammary gland

Animal models for the study of milk secretion

Biologie de la lactation

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