Abstract:BACKGROUND PUO refers to cases having prolonged fever the cause of which cannot be ascertained despite all diagnostic investigations. Pyrexia of unknown origin was best defined by Petersdorf and Beeson in 1961 after a study as "a temperature of 38.3 0 C (101 0 F) or greater on several occasions for more than 3 weeks duration and failure to reach a diagnosis despite 1 week of inpatient investigations". The diagnostic spectrum of PUO is changing over time and PUO remains a diagnostic challenge. Bone marrow exami… Show more
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