Mixed flow fan is a kind of widely used turbomachine, which has faced problems of further performance improvement in traditional design methods in recent decades. Inspired by the microgrooves such as riblets and denticles on bird feathers and shark skins, we here propose biomimetic designs of various blades with the bio-inspired grooves, aiming at the improvement of the aeroacoustic performance. Based on a systematic study with computational fluid dynamic analyses, we found that these designs had the potential in noise suppression even with macroscopic grooves. Our best design can suppress turbulence kinetic energy by approximately 38% at the blade leading edge with aerodynamic efficiency loss of only 0.3 percentage points. This improvement is achieved by passive flow control. The vortical structures are changed in a favorable way at the leading edge due to the grooves. We believe that these biomimetic designs could provide a promising future of enhancing the performance of mixed flow fans by making grooves of ideal flow passages on the suction faces of blades in accord with the theory of pump design.