Role of Birth Injury and Asphyxia in Idiopathic Epilepsy

Nielsen, J. M.; Courville, Cyril B.

doi:10.1212/wnl.1.1.48

Cited by 25 publications

(3 citation statements)

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“…This finding tends to support the theory that mesial temporal sclerosis can result from an early insult and not only from long standing intractable seizures during childhood [24], Although brain tumors are common in children [43]. they have not been considered a significant cause of pediatric epilepsy, having an incidence of between 0.2-2% [8,39,43]. More recent studies have shown that neo plasms play an important role in the etiology of pediatric seizure disorders [3,5,14,27,44], Our study also high lights the change in perception of the pathologic mecha nisms of epilepsy and presentation of temporal lobe lesions.…”

Section: Discussionmentioning

confidence: 53%

Temporal and Extended Temporal Resections for the Treatment of Intractable Seizures in Early Childhood

Ht³

et al. 1992

Pediatr Neurosurg

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In our series of 33 children who underwent temporal and extended temporal lobe resections because of seizures, the average age at surgery was 7 years, 11 months. Sixteen cases (48%) were diagnosed as having tumors: low-grade astrocytoma (6), hamartoma (5), and ganglioglioma/neuroma (5). Other pathologic diagnoses included one or more cytoarchitectural abnormalities and/or reactive changes. Due to a more aggressive and early radiologic and electrophysiologic investigation of children with seizures, a resectable focus, e.g. neoplasm or structural abnormality, was found in a much younger age group of patients than previously reported. In children who had intractable seizures but normal radiologic studies, positron emission tomography was of great value in localizing the seizure focus. In a group of children with infantile spasms, seizures were controlled following the identification and resection of a focal lesion. Prompt detection and precise localization of lesions in the temporal lobe in the pediatric population may lead to surgical management and seizure control.

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Section: Discussionmentioning

confidence: 53%

Temporal and Extended Temporal Resections for the Treatment of Intractable Seizures in Early Childhood

Ht³

et al. 1992

Pediatr Neurosurg

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“…[6] Besides genetic factors, a large number of pre-and perinatal factors, such as obstetric trauma, cerebral palsy, prematurity and neurological damage are widely believed to be important causes of epilepsy. [7][8][9][10] Human twins have to face a high frequency of such adverse perinatal events. They have also shown higher prevalence of epilepsy.…”

Section: Introductionmentioning

confidence: 99%

Genetic epidemiology of epilepsy: A twin study

Sharma

2005

Neurol India

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The study explored the genetic susceptibility and prevalence of epilepsy in twins. The data on epilepsy were retrieved from the health records of 199 pairs of twins. Proband concordance rate in monozygotic (MZ) twins was four times more than that in dizygotic (DZ) twins (0.67 vs. 0.17). Three of 15 (20%) affected twin kinships had epileptic first-degree relatives. These findings indicated significant underlying genetic susceptibility to epilepsy with the Holzinger's heritability estimate being 0.45. The prevalence of epilepsy was similar in MZ (45.45), DZ (45.11) twins, and their non-twin siblings (47.60). In the general population from various nationalities, the mean prevalence rate of epilepsy varied from 5 to 17 per 1000. The appreciably higher prevalence rate in twin kinships could be attributed to peculiar development factors associated with the twinning process or the intrauterine environment of mothers having tendencies to bear twins. Of the genetic markers, PTC locus seemed to be associated with the susceptibility to epilepsy. The allele frequency of non-tasters (t) seemed greater in epileptic twin kinships (0.71) than that in the general population (0.53). The frequency of non-tasters was similar in MZ and DZ twins and singletons: 27.3%, 26%, and 27.7% respectively. The PTC data on the general population was based on a sample of 278 individuals.

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“…Etiologically, epilepsy is classified as symptomatic (secondary) or idiopathic (essential, cryptogenic, or primary) depending on whether the cause is known or unknown. Symptomatic epilepsy may result from congenital or acquired lesions, while idiopathic epilepsy is said to exist when no lesion can be discovered (80). Paroxysmal discharges of cortical neurones are present in all cases, however.…”

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confidence: 99%

The physically handicapped.

Marzolf¹

An Introduction to Clinical Psychology, 2nd Ed.

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The Problem JLHE IMPORTANCE of sensory and motor function and the integrity of the entire neural apparatus for daily living is usually overlooked. However, even mild degrees of functional deficiency may unobtrusively, yet most assuredly, interfere with efficient living. Manifestly severe deficiencies in structure and impairment of function quite obviously present serious obstacles to optimal self-realization.The Baruch Committee on Physical Medicine, reporting in 1946, estimated that there were then in the United States 23,000,000 disabled persons, and in 1950 Linck placed the estimate at 28,000,000 (67). These estimates include the chronically ill and the aged. In 1943 the U. S. Public Health Service estimated that there were 16,000,000 disabled persons of working age, other than the institutionalized and those who were "essentially invalids." It is possible that these estimates are high, but even if the most conservative estimate that only 3 per cent of the population is disabled is correct, we have between four and five million in the United States (41). We are constrained by economic if not humane considerations to be concerned with the welfare of these persons.

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Role of Birth Injury and Asphyxia in Idiopathic Epilepsy

Cited by 25 publications

References 0 publications

Temporal and Extended Temporal Resections for the Treatment of Intractable Seizures in Early Childhood

Temporal and Extended Temporal Resections for the Treatment of Intractable Seizures in Early Childhood

Genetic epidemiology of epilepsy: A twin study

The physically handicapped.

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