Role of Biosurfactants in Biofilm Prevention and Disruption

Malakar, Chandana; Deka, Suresh; Kalita, Mohan Chandra

doi:10.1007/978-3-031-21682-4_22

Cited by 4 publications

(5 citation statements)

References 99 publications

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“…Although the mode of action of antibiofilm polysaccharides is not completely understood, these molecules act by modifying the physical properties of both biotic and abiotic surfaces [122,123]. Some exopolysaccharides can perform functions that inhibit or destabilize the biofilms without exhibiting biocidal or bacteriostatic activities [122,124]. Their antibiofilm activity is likely to be mediated by mechanisms other than growth inhibition [125][126][127][128][129][130][131][132][133][134][135][136][137][138][139].…”

Section: Antiadhesive Activity Of Bacterial Exopolysaccharidesmentioning

confidence: 99%

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Biobased Anti-Adhesive Marine Coatings from Polyhydroxyalkanoates and Polysaccharides

et al. 2023

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Due to environmental regulations, antifouling marine coatings must be gradually replaced by biocide-free coatings. Marine organisms weakly adhere to fouling release coatings, presenting a low surface free energy and a high elasticity, so they can be readily removed by the sheer force of water. Currently, these materials are mainly composed of petrochemical polymers, such as silicone or fluoropolymers, with hydrophilic polymers as additives. However, following the ever-increasing environmental concerns, the research on new, alternative, eco-friendly coatings is oriented towards the use of biobased polymers from renewable resources. Two main families have been studied: polyhydroxyalkanoates (PHAs) and polysaccharides. PHAs are produced by bacteria in stressful conditions, while polysaccharides are extracted from plants, animals, or micro-organisms such as bacteria, in which case they are called exopolysaccharides (EPS). Since the use of these polymers is a non-toxic approach to controlling fouling colonization, this review provides an overview of these biobased polymers for their applications in new anti-adhesive marine coatings.

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Section: Antiadhesive Activity Of Bacterial Exopolysaccharidesmentioning

confidence: 99%

“…Competitive inhibition of multivalent carbohydrate-protein interactions is another possible mode of action. Indeed, anti-biofilm polysaccharides might block lectins or sugar binding proteins present on the surface of bacteria or block tip adhesion of fimbriae and pili [124].…”

Section: Antiadhesive Activity Of Bacterial Exopolysaccharidesmentioning

confidence: 99%

Biobased Anti-Adhesive Marine Coatings from Polyhydroxyalkanoates and Polysaccharides

et al. 2023

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“…In summary, the unique properties of biosurfactants enable them to modify surface tension and the physicochemical characteristics of the environment, thereby disrupting microbial adhesion and impeding the formation of strong biofilm structures [29,30]. Furthermore, certain biosurfactants exhibit antimicrobial properties that directly target the viability and growth of microorganisms associated with biofilms, providing an additional barrier against biofilm development [31].…”

Section: Antibiofilm Activity Of I-bsmentioning

confidence: 99%

Extraction, Antibiofilm Activity and Characterization of Biosurfactant Produced by Limosilactobacillus reuteri IDCC 3701

Rafael

2023

MRJI

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Aims: This study aimed to extract and characterize a biosurfactant produced by Limosilactobacillus reuteri IDCC 3701, assess its emulsifying activity against crude oil, and investigate its antibiofilm properties against major foodborne pathogens. Methodology: The biosurfactant, named I-BS, was extracted from the cell-free supernatant of Limosilactobacillus reuteri IDCC 3701 using acid precipitation. The emulsification index, emulsifying activity, oil spreading test, drop collapse test, and microplate distortion assay were performed to evaluate the surfactant properties of I-BS. The antibiofilm activity of I-BS against foodborne pathogens was assessed using the Calgary Biofilm Device. Finally, the cell-free supernatant of Limosilactobacillus reuteri IDCC 3701 was subjected to GC-MS analysis. Results: I-BS demonstrated an emulsification index of 49.4% and emulsifying activity of 400.67, indicating its potential as an effective emulsifier for oils. Positive results were observed in the oil spreading test and microplate distortion assay, confirming its surfactant properties. Additionally, I-BS exhibited significant antibiofilm activity against foodborne pathogens. GC-MS analysis of the I-BS structure revealed the presence of octanoic acid, a surfactant compound. Conclusion: The biosurfactant I-BS, derived from Limosilactobacillus reuteri IDCC 3701, displayed promising emulsifying activity and demonstrated notable antibiofilm properties against foodborne pathogens. These findings suggest that I-BS holds potential as a lead compound for the development of novel anti-biofilm agents and additives in the food industry.

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“…Moreover, the capacity of bacteria to attach to inert material, polymers, and medical devices results in the formation of mature biofilms. Biofilm formation is considered as a significant risk factor for persistent infections, especially in implant recipients . The high mortality rates associated with hospital-acquired infections caused by biofilms are a worldwide public health problem .…”

Section: Introductionmentioning

confidence: 99%

“…Biofilm formation is considered as a significant risk factor for persistent infections, especially in implant recipients. 9 The high mortality rates associated with hospital-acquired infections caused by biofilms are a worldwide public health problem. 10 Therefore, the development of materials or technologies that prevent bacterial attachment and biofilm formation is urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance to conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible to a range of multidrug-resistant pathogens. These pathogens show reduced susceptibility to antibiotics and increased intracellular survival. However, current methods for treating biofilms, such as smart materials and targeted drug delivery systems, have not been found effective in preventing biofilm formation. To address this challenge, nanotechnology has provided innovative solutions for preventing and treating biofilm formation by clinically relevant pathogens. Recent advances in nanotechnological strategies, including metallic nanoparticles, functionalized metallic nanoparticles, dendrimers, polymeric nanoparticles, cyclodextrin-based delivery, solid lipid nanoparticles, polymer drug conjugates, and liposomes, may provide valuable technological solutions against infectious diseases. Therefore, it is imperative to conduct a comprehensive review to summarize the recent advancements and limitations of advanced nanotechnologies. The present Review encompasses a summary of infectious agents, the mechanisms that lead to biofilm formation, and the impact of pathogens on human health. In a nutshell, this Review offers a comprehensive survey of the advanced nanotechnological solutions for managing infections. A detailed presentation has been made as to how these strategies may improve biofilm control and prevent infections. The key objective of this Review is to summarize the mechanisms, applications, and prospects of advanced nanotechnologies to provide a better understanding of their impact on biofilm formation by clinically relevant pathogens.

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Role of Biosurfactants in Biofilm Prevention and Disruption

Cited by 4 publications

References 99 publications

Biobased Anti-Adhesive Marine Coatings from Polyhydroxyalkanoates and Polysaccharides

Biobased Anti-Adhesive Marine Coatings from Polyhydroxyalkanoates and Polysaccharides

Extraction, Antibiofilm Activity and Characterization of Biosurfactant Produced by Limosilactobacillus reuteri IDCC 3701

Advances in Nanotechnology for Biofilm Inhibition

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