Role of Biosensing Technology for NeuroAIDS Management

Jayant, Rahul Dev; Nair, M. G.

doi:10.4172/2155-6210.1000e141

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…In certain oxidation states conductive polymers present a metal-like conductivity but with an upgraded surface area due to the polymer fibril network in contact with the electrolyte. 9,10 Particularly, polyaniline (PANI) has been often used in energy storage devices, due to its easy and low-cost synthesis and high stability and electroactivity in acidic solutions. 11 However, to prepare electrodes with enhanced neutral-aqueous-solution electroactivity, PANI is usually doped with anionic polyelectrolytes.…”

Section: Introductionmentioning

confidence: 99%

Ferrocene-labelled surfactants enhance the supercapacitor performance in PANI-PSS/nanocarbon layer-by-layer nanoarchitectonics electrodes

Mártire,

Fenoy,

Azzaroni

et al. 2024

RSC Appl. Interfaces

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Section: Introductionmentioning

confidence: 99%

Ferrocene-labelled surfactants enhance the supercapacitor performance in PANI-PSS/nanocarbon layer-by-layer nanoarchitectonics electrodes

Mártire,

Fenoy,

Azzaroni

et al. 2024

RSC Appl. Interfaces

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<p>In-vitro blood-brain barrier models for drug screening and permeation studies: an overview</p>

Bagchi¹,

Chhibber²,

Lahooti³

et al. 2019

DDDT

158

119

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The blood-brain barrier (BBB) is comprised of brain microvascular endothelial central nervous system (CNS) cells, which communicate with other CNS cells (astrocytes, pericytes) and behave according to the state of the CNS, by responding against pathological environments and modulating disease progression. The BBB plays a crucial role in maintaining homeostasis in the CNS by maintaining restricted transport of toxic or harmful molecules, transport of nutrients, and removal of metabolites from the brain. Neurological disorders, such as NeuroHIV, cerebral stroke, brain tumors, and other neurodegenerative diseases increase the permeability of the BBB. While on the other hand, semipermeable nature of BBB restricts the movement of bigger molecules i.e. drugs or proteins (>500 kDa) across it, leading to minimal bioavailability of drugs in the CNS. This poses the most significant shortcoming in the development of therapeutics for CNS neurodegenerative disorders. Although the complexity of the BBB (dynamic and adaptable barrier) affects approaches of CNS drug delivery and promotes disease progression, understanding the composition and functions of BBB provides a platform for novel innovative approaches towards drug delivery to CNS. The methodical and scientific interests in the physiology and pathology of the BBB led to the development and the advancement of numerous in vitro models of the BBB. This review discusses the fundamentals of BBB structure, permeation mechanisms, an overview of all the different in-vitro BBB models with their advantages and disadvantages, and rationale of selecting penetration prediction methods towards the critical role in the development of the CNS therapeutics.

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Advancements in nano-enabled therapeutics for neuroHIV management

Jayant¹,

Nair²

2016

IJN

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This viewpoint is a global call to promote fundamental and applied research aiming toward designing smart nanocarriers of desired properties, novel noninvasive strategies to open the blood-brain barrier (BBB), delivery/release of single/multiple therapeutic agents across the BBB to eradicate neurohuman immunodeficiency virus (HIV), strategies for on-demand site-specific release of antiretroviral therapy, developing novel nanoformulations capable to recognize and eradicate latently infected HIV reservoirs, and developing novel smart analytical diagnostic tools to detect and monitor HIV infection. Thus, investigation of novel nanoformulations, methodologies for site-specific delivery/release, analytical methods, and diagnostic tools would be of high significance to eradicate and monitor neuroacquired immunodeficiency syndrome. Overall, these developments will certainly help to develop personalized nanomedicines to cure HIV and to develop smart HIV-monitoring analytical systems for disease management.

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Role of Biosensing Technology for NeuroAIDS Management

Cited by 4 publications

References 12 publications

Ferrocene-labelled surfactants enhance the supercapacitor performance in PANI-PSS/nanocarbon layer-by-layer nanoarchitectonics electrodes

Ferrocene-labelled surfactants enhance the supercapacitor performance in PANI-PSS/nanocarbon layer-by-layer nanoarchitectonics electrodes

<p>In-vitro blood-brain barrier models for drug screening and permeation studies: an overview</p>

Advancements in nano-enabled therapeutics for neuroHIV management

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