Role of biophysics and mechanobiology in podocyte physiology

Haydak, Jonathan; Azeloglu, Evren U.

doi:10.1038/s41581-024-00815-3

Cited by 4 publications

(1 citation statement)

References 170 publications

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“…Podocytes, when exposed to physiological stresses such as the shear stress of ultrafiltrate, demonstrate adaptability through their unique mechanical biology to sustain function. 79 However, when these mechanical stresses surpass the podocyte's tolerance threshold, this biological equilibrium is disrupted, resulting in the loss of glomerular function. Podocyte injury stems from various factors, including mechanical, oxidative, and immune stresses, with the formation of subepithelial immune complexes and complement activation being pivotal.…”

Section: Pathogenesis Of Mnmentioning

confidence: 99%

Membranous nephropathy: pathogenesis and treatments

Wang,

Yang,

Fang

et al. 2024

MedComm

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Membranous nephropathy (MN), an autoimmune disease, can manifest at any age and is among the most common causes of nephrotic syndrome in adults. In 80% of cases, the specific etiology of MN remains unknown, while the remaining cases are linked to drug use or underlying conditions like systemic lupus erythematosus, hepatitis B virus, or malignancy. Although about one‐third of patients may achieve spontaneous complete or partial remission with conservative management, another third face an elevated risk of disease progression, potentially leading to end‐stage renal disease within 10 years. The identification of phospholipase A2 receptor as the primary target antigen in MN has brought about a significant shift in disease management and monitoring. This review explores recent advancements in the pathophysiology of MN, encompassing pathogenesis, clinical presentations, diagnostic criteria, treatment options, and prognosis, with a focus on emerging developments in pathogenesis and therapeutic strategies aimed at halting disease progression. By synthesizing the latest research findings and clinical insights, this review seeks to contribute to the ongoing efforts to enhance our understanding and management of this challenging autoimmune disorder.

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Section: Pathogenesis Of Mnmentioning

confidence: 99%

Membranous nephropathy: pathogenesis and treatments

Wang,

Yang,

Fang

et al. 2024

MedComm

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Quantification of urinary podocyte‐derived migrasomes for the diagnosis of kidney disease

Yang,

Zhang,

Chen

et al. 2024

J of Extracellular Vesicle

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Migrasomes represent a recently uncovered category of extracellular microvesicles, spanning a diameter range of 500 to 3000 nm. They are emitted by migrating cells and harbour a diverse array of RNAs and proteins. Migrasomes can be readily identified in bodily fluids like serum and urine, rendering them a valuable non‐invasive source for disease diagnosis through liquid biopsy. In this investigation, we introduce a streamlined and effective approach for the capture and quantitative assessment of migrasomes, employing wheat germ agglutinin (WGA)‐coated magnetic beads and flow cytometry (referred to as WBFC). Subsequently, we examined the levels of migrasomes in the urine of kidney disease (KD) patients with podocyte injury and healthy volunteers using WBFC. The outcomes unveiled a substantial increase in urinary podocyte‐derived migrasome concentrations among individuals with KD with podocyte injury compared to the healthy counterparts. Notably, the urinary podocyte‐derived migrasomes were found to express an abundant quantity of phospholipase A2 receptor (PLA2R) proteins. The presence of PLA2R proteins in these migrasomes holds promise for serving as a natural antigen for the quantification of autoantibodies against PLA2R in the serum of patients afflicted by membranous nephropathy. Consequently, our study not only pioneers a novel technique for the isolation and quantification of migrasomes but also underscores the potential of urinary migrasomes as a promising biomarker for the early diagnosis of KD with podocyte injury.

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Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy

Nagase,

Nagase

2024

Hypertens Res

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Role of biophysics and mechanobiology in podocyte physiology

Cited by 4 publications

References 170 publications

Membranous nephropathy: pathogenesis and treatments

Membranous nephropathy: pathogenesis and treatments

Quantification of urinary podocyte‐derived migrasomes for the diagnosis of kidney disease

Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy

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