Role of biomarkers CA-125, CA-15.3 and CA-19.9 in the distinction between endometriomas and ovarian neoplasms

Magalhães, Jéssica de Souza; Jammal, Millena Prata; Crispim, Paula Carolina Arvelos; Murta, Eddie Fernando Cândido; Nomelini, Rosekeila Simões

doi:10.1080/1354750x.2021.1885490

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…Serum levels of LDH and uric acid are usually elevated in patients affected by Non-Hodgkin lymphomas ( 16 ) and high levels of CA-125 have been associated with primary ovarian lymphomas ( 3 ). These serum markers may help differentiate between benign and malignant lesions, although they are not specific; high levels of serum LDH can be observed in advanced-stage germ cell tumors or in epithelial tumors ( 5 , 17 ), while high level of CA-125 might be suggestive of epithelial tumors ( 5 ) or endometriosis ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: Primary ovarian Burkitt's lymphoma: A puzzling scenario in pediatric population

et al. 2023

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Burkitt's lymphoma (BL) is defined as a highly invasive B-cell lymphoma, usually characterized by an excellent prognosis, more than 90% of children and adolescents being cured with highly dose-intensive multiagent chemotherapy. Primary ovarian localization without involvement of other organs is a rare manifestation of BL, especially in pediatric population. Symptoms at diagnosis are similar to other ovarian lesions and differential diagnosis may be challenging for clinicians. A 12-year-old girl was referred to our institution for abdominal pain and palpable mass observed by the pediatrician. Diagnostic work-up demonstrated a large mass arising from the right ovary, causing compression on abdominal aorta, inferior vena cava, ureters and bowel, with a second smaller lesion on the left ovary. At surgery, a 15 cm-large, ruptured mass arising from the right ovary was found, associated with a second lesion originating from the left ovary (8 cm) and multiple nodules of the greater omentum. Right salpingo-oophorectomy was performed, incisional biopsies were taken from the left ovary and omental nodules and peritoneal fluid samples were collected for cytology. Pathology revealed a Burkitt lymphoma and the patient underwent chemotherapy according to AIEOP LNH-97 Protocol, group R3 with Rituximab. Preoperative diagnosis of primary ovarian lymphoma is extremely difficult. Surgical exploration is often necessary in patients presenting with acute abdominal or pelvic pain; when the suspicion of primary ovarian lymphoma arises intraoperatively, every effort should be made to minimize invasive procedure in order to enhance post-operative recovery.

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Section: Discussionmentioning

confidence: 99%

Case report: Primary ovarian Burkitt's lymphoma: A puzzling scenario in pediatric population

et al. 2023

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“…The tumor marker CA-125 is now generally acknowledged as a predictive and prognostic factor in CA-125-positive ovarian cancers [7,8]. The most common site of endometriotic lesions is the ovary [9][10][11]. Ovarian cysts typically develop during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Endometriotic Cystic Ovaries and Huge Splenic Epithelial Cyst With Elevated CA-125, CA19-9: A Report of a Rare Case

Abdulla,

Saeed,

Abdul Aziz

et al. 2023

Cureus

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Histologically benign splenic cysts (SCs) resemble splenic sacs. SCs are rare. Here, we present and discuss a new case of bilateral endometriotic cystic ovaries with massive SCs. A 26-year-old single female visited the hospital with left lower quadrant discomfort and suprapubic pain for three months, accompanied by anorexia, weight loss for these three months, and persistent dysmenorrhea for two years. Splenic examination revealed a soft abdomen with left hypochondria, suprapubic tenderness, and a lump in the upper left quadrant. All laboratory results were normal, except for two cancer antigens (CA-125 and CA 19-9). Therefore, magnetic resonance imaging was used to make the definitive diagnosis, which revealed bilateral ovarian endometrioma with a left upper abdominal cystic mass of splenic origin. When CA-125 and CA-19-9 readings are high, physicians should investigate endometriotic and SCs. Imaging aids diagnosis. Histopathological results are essential. Tools and follow-up should rule out malignancy, and surgery is the best treatment option.

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“…CA19.9 is a potential serum marker for diagnosing EAOC; in Magalhães et al. study, a serum CA19.9 >22.31 U/ml showed a sensitivity of 82.14% in distinguishing between ovarian endometriotic cysts and EAOC ( 67 ). HE4, highly expressed in ovarian cancer and unaffected by endometriosis, exhibits high specificity.…”

Section: Clinical Diagnosis Of Eaocmentioning

confidence: 97%

Research progress in endometriosis-associated ovarian cancer

Tang,

Bian

2024

Front. Oncol.

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Endometriosis-associated ovarian cancer (EAOC) is a unique subtype of ovarian malignant tumor originating from endometriosis (EMS) malignant transformation, which has gradually become one of the hot topics in clinical and basic research in recent years. According to clinicopathological and epidemiological findings, precancerous lesions of ovarian clear cell carcinoma (OCCC) and ovarian endometrioid carcinoma (OEC) are considered as EMS. Given the large number of patients with endometriosis and its long time window for malignant transformation, sufficient attention should be paid to EAOC. At present, the pathogenesis of EAOC has not been clarified, no reliable biomarkers have been found in the diagnosis, and there is still a lack of basis and targets for stratified management and precise treatment in the treatment. At the same time, due to the long medical history of patients, the fast growth rate of cancer cells, and the possibility of eliminating the earliest endometriosis-associated ovarian cancer, it is difficult to find the corresponding histological evidence. As a result, few patients are finally diagnosed with EAOC, which increases the difficulty of in-depth study of EAOC. This article reviews the epidemiology, pathogenesis, risk factors, clinical diagnosis, new treatment strategies and prognosis of endometriosis-associated ovarian cancer, and prospects the future direction of basic research and clinical transformation, in order to achieve stratified management and personalized treatment of ovarian cancer patients.

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Role of biomarkers CA-125, CA-15.3 and CA-19.9 in the distinction between endometriomas and ovarian neoplasms

Cited by 9 publications

References 16 publications

Case report: Primary ovarian Burkitt's lymphoma: A puzzling scenario in pediatric population

Case report: Primary ovarian Burkitt's lymphoma: A puzzling scenario in pediatric population

Bilateral Endometriotic Cystic Ovaries and Huge Splenic Epithelial Cyst With Elevated CA-125, CA19-9: A Report of a Rare Case

Research progress in endometriosis-associated ovarian cancer

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