Role of Biologic Markers in Epidemiologic Studies of Prenatal Drug Exposure: Issues in Study Design

Mb, Bracken; Leaderer, Brian P.; Belanger, Kathleen

doi:10.1037/e496172006-006

PsycEXTRA Dataset 1992

DOI: 10.1037/e496172006-006

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Role of Biologic Markers in Epidemiologic Studies of Prenatal Drug Exposure: Issues in Study Design

Bracken Mb

Brian P. Leaderer²,

Kathleen Belanger³

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Effect of Maternal Smoking and Coffee Consumption on the Risk of Having a Recognized Down Syndrome Pregnancy

Torfs¹,

Christianson²

2000

American Journal of Epidemiology

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To evaluate the possible effects of maternal smoking and caffeine or coffee consumption on the occurrence of a recognized pregnancy with Down syndrome, the authors analyzed data from a case-control study of 997 liveborn infants or fetuses with Down syndrome ascertained in California from 1991 to 1993 and 1,007 liveborn controls without a birth defect. Interviews with mothers covered demographic information, pregnancy, and medical history, with detailed questions on the use of tobacco, alcohol, and caffeinated beverages. All analyses were age-adjusted. High alcohol consumption (> or =4 drinks/week) in the first month of pregnancy was associated with reduced risk for a recognized Down syndrome conceptus (odds ratio (OR) = 0.54; 95% confidence interval (CI): 0.34, 0.85). Maternal smoking during the periconceptional period was not associated with risk of recognized Down syndrome (OR = 1.04; 95% CI: 0.79, 1.37), but maternal consumption of four or more cups of coffee per day was inversely associated (OR = 0.63; 95% CI: 0.41, 0.96). In multivariate analysis, a significant interaction between coffee drinking and smoking was observed. The inverse association remained only for nonsmoking mothers who drank four or more cups of coffee per day (OR = 0.48; 95% CI: 0.28, 0.82). These results suggest that among nonsmoking mothers, high coffee consumption is more likely to reduce the viability of a Down syndrome conceptus than that of a normal conceptus.

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Effect of Maternal Smoking and Coffee Consumption on the Risk of Having a Recognized Down Syndrome Pregnancy

Torfs¹,

Christianson²

2000

American Journal of Epidemiology

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How to Avoid Epidemiologic Failure

Schuman¹

1998

Journal of Agromedicine

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Role of Biologic Markers in Epidemiologic Studies of Prenatal Drug Exposure: Issues in Study Design

Cited by 2 publications

References 0 publications

Effect of Maternal Smoking and Coffee Consumption on the Risk of Having a Recognized Down Syndrome Pregnancy

Effect of Maternal Smoking and Coffee Consumption on the Risk of Having a Recognized Down Syndrome Pregnancy

How to Avoid Epidemiologic Failure

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