Role of Bioinformatics in Non-coding RNA Analysis

Mathuria, Anshu; Mehak,; Mani, Indra

doi:10.1007/978-981-99-8401-5_5

Advances in Bioinformatics 2024

DOI: 10.1007/978-981-99-8401-5_5

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Role of Bioinformatics in Non-coding RNA Analysis

Anshu Mathuria,

Mehak,

Indra Mani

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2024

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Cited by 2 publications

References 89 publications

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LncRNAs involvement in pathogenesis of immune-related disease via regulation of T regulatory cells, an updated review

Khalilollah,

Kalantari Soltanieh,

Obaid Saleh

et al. 2024

Cytokine

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LncRNAs involvement in pathogenesis of immune-related disease via regulation of T regulatory cells, an updated review

Khalilollah,

Kalantari Soltanieh,

Obaid Saleh

et al. 2024

Cytokine

View full text Add to dashboard Cite

Exploration of microRNAs as transcriptional regulator in mumps virus infection through computational studies

Hassan,

Shahzadi,

Iqbal

et al. 2024

Sci Rep

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Mumps is a common childhood infection caused by the mumps virus (MuV). Aseptic meningitis and encephalitis are usual symptoms of mumps together with orchitis and oophoritis that can arise in males and females, respectively. We have used computational tools: RNA22, miRanda and psRNATarget to predict the microRNA-mRNA binding sites to find the putative microRNAs playing role in the host response to mumps virus infection. Our computational studies indicate that hsa-mir-3155a is most likely involved in mumps infection. This was further investigated by the prediction of binding sites of hsa-mir-3155a to the MuV genome. Additionally, structure prediction using MC-Fold and MC-Sym, respectively has been applied to predict the 3D structures of miRNA and mRNA. The miRNA-mRNA interaction profile between has been confirmed through molecular docking simulation studies. Taken together, the putative miRNA (hsa_miR_6794_5p) has been found to be most likely involved in the regulation of transcriptional activity in the MuV infection.

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Role of Bioinformatics in Non-coding RNA Analysis

Cited by 2 publications

References 89 publications

LncRNAs involvement in pathogenesis of immune-related disease via regulation of T regulatory cells, an updated review

LncRNAs involvement in pathogenesis of immune-related disease via regulation of T regulatory cells, an updated review

Exploration of microRNAs as transcriptional regulator in mumps virus infection through computational studies

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