Role of bioinformatics and pharmacogenomics in drug discovery and development process

Abstract

Drug discovery and development is a complex, high risk, time consuming and potentially highly rewarding process. Pharmaceutical companies literally burn millions of dollar per drug to bring it to the market. The development of a new drug requires a technological expertise, human resources and huge capital investment. It also requires strict adherence to regulations on testing and manufacturing standards before a new drug comes into market and can be used in the general population, in fact, some time it fails to come into market. All these factors just increase the cost for a new chemical entity research and development. Two branches which made positive impact on drug designing process and reduce the overall cost and risk are Bioinformatics and Pharmacogenomics. Their practice in drug designing process made positive effect on overall process and they can accelerate various steps of drug designing, and reduce the cost and over all time. Current note focusses on the role of bioinformatics and pharmacogenomics in drug discovery and development process.

Search for in-Silico Applications in Drug Discovery and Applications of Different Disciplines in It: A Survey

“…Another field of study, known as pharmacogenomics, has also become effective in selection of optimal drug, its dose, its treatment process and its side effects [66]. It is the combined study of pharmacology and genomics i.e.…”

Use of Bioinformatics Tools in Different Spheres of Life Sciences

“…The whole process of discovering and designing new drug molecules is quite complicated and is quite challenging. The entire process can be divided into four different steps: identification of drug target, validation of target, lead identification, and lead optimization [92]. In this section, we will briefly discuss how bioinformatics is useful in discovering new drugs.…”

“…The sequencing of human genome provided over 30,000 genes to researchers to include them in their search for new drug targets [93]. Since then the number of potential drug targets is increasing day-by-day [92]. Understanding how a gene functions is indeed a key to choose a gene as a target.…”

Implementing a web‐based introductory bioinformatics course for non‐bioinformaticians that incorporates practical exercises

“…Since then, this contemporary discipline, which combines concepts of biological and computer sciences, is closely involved in several fields of modern sciences such as personal medicine [3], vaccine design [4], drug discovery [5], and the study of infectious diseases [6].…”