Role of biogenic amines in certain pathological conditions

Subrahmanyam, Sarada

doi:10.1016/0006-8993(75)90433-3

Cited by 40 publications

(11 citation statements)

References 14 publications

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“…In this study we did not find any decrease in lumbar CSF amine metabolite concentrations in depressed patients during illness as has been reported for 5-HIAA Subrahmanyam (1975)). The normal levels of 5-HIAA and MHPG found in depressed patients in this study are in accord with reports by Roos & Sjostrom (1969) and Wilk et al (1972), and O'Keefe & Brooksbank (1973), respectively.…”

Section: Discussionsupporting

confidence: 68%

Biogenic amine metabolites in cerebrospinal fluid of patients with affective disorders

Vestergaard

Sørensen

Hoppe

et al. 1978

Acta Psychiatr Scand

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Concentrations of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4hydroxyphenylglycol (MHPG) were measured in lumbar CSF from 33 patients with affective illness and from 23 neurological controls. The group of patients with affective illness comprised 29 depressed and four manic patients. During illness, the concentration of HVA was higher in the depressed patients (P < 0.001) than in the controls. Both unipolar and bipolar depressed patients had increased HVA levels (P < 0.001 and P < 0.05, respectively). The concentration of MHPG was greater than control values in the unipolar (P < 0.01) and bipolar (P < 0.02) subgroups but did not differ from control values in the depressed group as a whole. The concentration of 5-HIAA in the depressed patients as a whole and in the unipolar and bipolar subgroups did not differ from control concentrations. During illness the manic patients had increased levels of HVA (P < 0.01) and normal levels of 5-HIAA and MHPG. Sixteen of the 29 depressed patients had a second lumbar puncture after they had r e covered. Compared with the pre-recovery values, the concentration of HVA was reduced in the unipolar depressives (P < 0.01) and the concentration of 5-HIAA lowered in the depressed group as a whole (P < 0.02).The present findings suggest involvement of catecholamines in affective disorders.

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Section: Discussionsupporting

confidence: 68%

Biogenic amine metabolites in cerebrospinal fluid of patients with affective disorders

Vestergaard

Sørensen

Hoppe

et al. 1978

Acta Psychiatr Scand

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“…Interestingly, pramipexole and bromocriptine improved the mood of bipolar disorder depressed patients (Silverstone, 1984; Zarate et al, 2004), supporting a catecholamine deficiency during depression. Other support for a hypodopaminergic state during depression comes from reduced cerebrospinal fluid (CSF) levels of the metabolite of dopamine homovanillic acid in untreated bipolar disorder depressed patients (Subrahmanyam, 1975; Gerner et al, 1984). When bipolar disorder depressed patients were treated with medication, normal or increased homovanillic acid levels were observed compared to controls.…”

Section: The Original Adrenergic-cholinergic Balance Hypothesis Ofmentioning

confidence: 99%

The catecholaminergic–cholinergic balance hypothesis of bipolar disorder revisited

Enkhuizen

Janowsky

Olivier

et al. 2015

European Journal of Pharmacology

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Bipolar disorder is a unique illness characterized by fluctuations between mood states of depression and mania. Originally, an adrenergic-cholinergic balance hypothesis was postulated to underlie these different affective states. In this review, we update this hypothesis with recent findings from human and animal studies, suggesting that a catecholaminergic-cholinergic hypothesis may be more relevant. Evidence from neuroimaging studies, neuropharmacological interventions, and genetic associations support the notion that increased cholinergic functioning underlies depression, whereas increased activations of the catecholamines (dopamine and norepinephrine) underlie mania. Elevated functional acetylcholine during depression may affect both muscarinic and nicotinic acetylcholine receptors in a compensatory fashion. Increased functional dopamine and norepinephrine during mania on the other hand may affect receptor expression and functioning of dopamine reuptake transporters. Despite increasing evidence supporting this hypothesis, a relationship between these two neurotransmitter systems that could explain cycling between states of depression and mania is missing. Future studies should focus on the influence of environmental stimuli and genetic susceptibilities that may affect the catecholaminergic-cholinergic balance underlying cycling between the affective states. Overall, observations from recent studies add important data to this revised balance theory of bipolar disorder, renewing interest in this field of research.

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“…Although the sample size was small, both unipolar and bipolar patients were reported to have similar, reduced levels of HVA (Jimerson and Berrettini, 1985;Asberg et al, 1984). When depressed patients were not given drug washout periods or not compared with matched controls, HVA levels were reported to be either increased or not changed, compared with controls (Gerner et al, 1984;Subrahmanyam, 1975). Interestingly, CSF levels of HVA have been reported to be elevated in depressed patients that also showed psychotiddelusional symptoms (Aberg-Wistedt et al, 1985;Sweeney et al, 1978).…”

Section: Biochemical Measures In Humans and Animal Modelsmentioning

confidence: 99%

Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories

Caldecott-Hazard

Morgan

DeLeon-Jones

et al. 1991

Synapse

116

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The present document is the second of three parts in a review that focuses on recent data from clinical and animal research concerning the biochemical bases of depressive disorders, diagnosis, and treatment. Various receptor/transmitter theories of depressive disorders are discussed in this section. Specifically, data supporting noradrenergic, serotonergic, cholinergic, dopaminergic, GABAergic, and peptidergic theories, as well as interactions between noradrenergic and serotonergic, or cholinergic and catecholaminergic systems are presented. Problems with the data and future directions for research are also discussed. A previous publication, Part I of this review, dealt with the classification of depressive disorders and research techniques for studying the biochemical mechanisms of these disorders. A future publication, Part III of this review, discusses treatments for depression and some of the controversies in this field.

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Role of biogenic amines in certain pathological conditions

Cited by 40 publications

References 14 publications

Biogenic amine metabolites in cerebrospinal fluid of patients with affective disorders

Biogenic amine metabolites in cerebrospinal fluid of patients with affective disorders

The catecholaminergic–cholinergic balance hypothesis of bipolar disorder revisited

Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories

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