Role of biobanks in transplantation

Hanif, Zulfiqar; Sufiyan, N.; Patel, Manish Kumar; Akhtar, Marjahan

doi:10.1016/j.amsu.2018.02.007

Cited by 11 publications

(5 citation statements)

References 30 publications

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“…While the relationship between recipient kidney injury biomarkers and outcomes is relatively clear, the relationship between donor kidney injury biomarkers and recipient outcomes is more complex [134, 148]. In order to lift the hurdles preventing the discovery of new early and effective biomarkers, the generation of biobanks [149] and the use of laboratory for reconditioning the organ [150] (machine perfusion, ex vivo circulation, for instance) are important perspectives to set up projects looking for “ideal” biomarker.…”

Section: Predicting the Future: The Importance Of Biomarkersmentioning

confidence: 99%

Barriers and Advances in Kidney Preservation

Steichen

Giraud

Bon

et al. 2018

BioMed Research International

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Despite the fact that a significant fraction of kidney graft dysfunctions observed after transplantation is due to ischemia-reperfusion injuries, there is still no clear consensus regarding optimal kidney preservation strategy. This stems directly from the fact that as of yet, the mechanisms underlying ischemia-reperfusion injury are poorly defined, and the role of each preservation parameter is not clearly outlined. In the meantime, as donor demography changes, organ quality is decreasing which directly increases the rate of poor outcome. This situation has an impact on clinical guidelines and impedes their possible harmonization in the transplant community, which has to move towards changing organ preservation paradigms: new concepts must emerge and the definition of a new range of adapted preservation method is of paramount importance. This review presents existing barriers in transplantation (e.g., temperature adjustment and adequate protocol, interest for oxygen addition during preservation, and clear procedure for organ perfusion during machine preservation), discusses the development of novel strategies to overcome them, and exposes the importance of identifying reliable biomarkers to monitor graft quality and predict short and long-term outcomes. Finally, perspectives in therapeutic strategies will also be presented, such as those based on stem cells and their derivatives and innovative models on which they would need to be properly tested.

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Section: Predicting the Future: The Importance Of Biomarkersmentioning

confidence: 99%

Barriers and Advances in Kidney Preservation

Steichen

Giraud

Bon

et al. 2018

BioMed Research International

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“…BOS is mediated by several mechanisms, such as alloimmune reactivity, humoral and autoimmunity, activation of innate immune cells and response to nonimmune-related allograft insults, such as infection and aspiration [ 12 ]. Employing a systematic approach for the collection of clinical data and the storage of samples can be useful for improving the knowledge of BOS research [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Evidence of aberrant angiogenesis has also been reported in bronchiolitis obliterans lesions, consisting of the proliferation and enlargement of the microvasculature [ 14 , 15 ]. This mechanism could explain the flow limitation and dyspnoea typical of patients with BOS [ 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Markers of Bronchiolitis Obliterans Syndrome after Lung Transplant: Between Old Knowledge and Future Perspective

et al. 2022

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Bronchiolitis obliterans syndrome (BOS) is the most common form of CLAD and is characterized by airflow limitation and an obstructive spirometric pattern without high-resolution computed tomography (HRCT) evidence of parenchymal opacities. Computed tomography and microCT analysis show abundant small airway obstruction, starting from the fifth generation of airway branching and affecting up to 40–70% of airways. The pathogenesis of BOS remains unclear. It is a multifactorial syndrome that leads to pathological tissue changes and clinical manifestations. Because BOS is associated with the worst long-term survival in LTx patients, many studies are focused on the early identification of BOS. Markers may be useful for diagnosis and for understanding the molecular and immunological mechanisms involved in the onset of BOS. Diagnostic and predictive markers of BOS have also been investigated in various biological materials, such as blood, BAL, lung tissue and extracellular vesicles. The aim of this review was to evaluate the scientific literature on markers of BOS after lung transplant. We performed a systematic review to find all available data on potential prognostic and diagnostic markers of BOS.

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“…Занимая доминирующее место в области изучения онкологии человека [5,6], биобанки постепенно становятся неотъемлемой частью современных исследований и в других областях медицины [3,7,8], в т.ч. в области инфекционных заболеваний [9][10][11][12].…”

Section: Introductionunclassified

Creation of a collection of different biological sample types from elderly patients to study the relationship of clinical, systemic, tissue and cellular biomarkers of accumulation of senescent cells during aging

Sorokina

Orlova

Grigorieva

et al. 2022

Cardiovasc Ther Prev

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With aging, tissue homeostasis and their effective recovery after damage is violated. It has been shown that this may be due to the excessive accumulation of senescent (SC) cells in various tissues, which leads to the activation of chronic sterile inflammation, tissue dysfunction and, as a result, to the development of age-related diseases. To assess the contribution of SC cells to human body aging and pathogenesis of such diseases, relevant biomarkers are studied. For successful translation into clinical practice of approaches aimed at regulating the SC cell content in various tissues, it is necessary to study the relationship between the established clinical biomarkers of aging and age-related diseases, systemic aging parameters, and SC biomarkers at the tissue and cellular levels.Aim. To develop and describe action algorithms for creating a biobank of samples obtained from patients aged >65 years in order to study biomarkers of SC cell accumulation.Material and methods. To collect samples, an interaction system was built between several research, clinical and infrastructure departments of a multidisciplinary medical center. At the stage of preanalytical training, regulatory legal acts were developed, including informed consent for patients, as well as protocols for each stage of the study.Results. A roadmap was formed with action algorithms for all participants in the study, as well as with a convenient and accessible system of annotations and storage of biological samples. To date, the collection includes biological samples of 7 different types (peripheral blood serum, formalin-fixed tissue samples and formalin fixed paraffin embedded tissue specimens, samples of different cells isolated from peripheral blood, skin and adipose tissue, samples of deoxyribonucleic and ribonucleic acids, cell secretome conditioned media) obtained from 82 patients. We accumulated relevant anamnestic, clinical and laboratory data, as well as the results of experimental studies to assess the SC cell biomarkers. Using the collection, the relationship between clinical, tissue and cellular biomarkers of SC cell accumulation was studied.Conclusion. The creation of a collection of biological samples at the molecular, cellular, tissue and organism levels from one patient provides great opportunities for research in the field of personalized medicine and the study of age-related disease pathogenesis.

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Role of biobanks in transplantation

Cited by 11 publications

References 30 publications

Barriers and Advances in Kidney Preservation

Barriers and Advances in Kidney Preservation

Markers of Bronchiolitis Obliterans Syndrome after Lung Transplant: Between Old Knowledge and Future Perspective

Creation of a collection of different biological sample types from elderly patients to study the relationship of clinical, systemic, tissue and cellular biomarkers of accumulation of senescent cells during aging

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