Role of beta adrenoceptors in metabolic and cardiovascular responses of cold exposed humans

Šimečková, Marie; Janský, L; Lesná, I. Králová; Vybíral, S; Šrámek, P.

doi:10.1016/s0306-4565(00)00007-3

Cited by 27 publications

(10 citation statements)

References 22 publications

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“…additionally, as also determined in the present study, heart rate frequency of regular winter swimmers decreases during the immersion process (21).…”

Section: Discussionsupporting

confidence: 87%

Body surface temperature adaptations after ice-cold water immersion in regular winter swimmers

Gruszka¹,

Jędrzejewski²,

Sobiech³

et al. 2018

jbe

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“…additionally, as also determined in the present study, heart rate frequency of regular winter swimmers decreases during the immersion process (21).…”

Section: Discussionsupporting

confidence: 87%

Body surface temperature adaptations after ice-cold water immersion in regular winter swimmers

Gruszka¹,

Jędrzejewski²,

Sobiech³

et al. 2018

jbe

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“…Since cold exposure increases blood level of noradrenaline (Janský et al 1996b(Janský et al , 1997Vybíral et al 2000;Krámek et al 2000;Kimebková et al 2000), this approach comes out from the assumption that infusions of adrenergic substances, namely noradrenaline, simulate conditions of cold exposure. This procedure is routinely used to quantify intensity of nonshivering thermogenesis in animals and man (Janský et al 1967;Mejsnar and Janský 1971;Janský 1988;Lesná et al1999).…”

Section: Discussionmentioning

confidence: 99%

“…Since production of adrenaline was not changed during cold water immersions, it may be concluded that all the observed changes were due to action of noradrenaline. Further it was found that repeated exposures to cold water, inducing cold adaptation, did not inXuence blood level of noradrenaline, but lowered that of adrenaline (Janský et al 1996a(Janský et al , 1997Vybíral et al 2000;Krámek et al 2000;Kimebková et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Modulation of adrenergic receptors and adrenergic functions in cold adapted humans

et al. 2007

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To specify the role of adrenoceptors in mediating adrenergic functions after adaptation of humans to cold, effect of administration of increasing concentrations of beta1 and beta2 adrenomimetics (Dobutamine, Bricanyl) on resting metabolic rate, heart rate, systolic blood pressure, rectal and skin temperatures of control humans and of cold adapted winter swimmers was studied. Increase in metabolic rate, mediated by beta1 and beta2 adrenomimetics, was attenuated after cold adaptation, indicating downregulation of beta1 and beta2 adrenoceptors. Since cold adapted humans have greater capacity of nonshivering thermogenesis, than that mediated by both beta1 and beta2 adrenoceptors, the role of other subtypes of adrenoceptors in mediating nonshivering thermogenesis is anticipated. Heart rate increased after administration of the beta2 agonist, but was not influenced by the beta1 agonist. The significance of beta2 adrenoceptors in mediating heart rate was depressed after cold adaptation. Data indicate that modifications of activity of beta adrenoceptors play crucial role in mechanisms responsible for adaptation of humans to cold.

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“…Duchamp and Barre (1993) demonstrated that 70% of the non-shivering heat generated by ducklings during cold exposure was due to thermogenesis in skeletal muscle. Humans respond to cold exposure by increasing thermogenesis, which is regulated by the central nervous system via sympathetic stimulation (Dauncey 1981; Paolone and Paolone 1995; Simeckova et al 2000; van Marken Lichtenbelt and Daanen 2003). As discussed above, epinephrine has been shown to activate thermogenesis, showing that skeletal muscle is involved in cold-induced thermogenesis.…”

Section: Adaptive Thermogenesis and The Role Of Musclementioning

confidence: 99%

The role of the myosin ATPase activity in adaptive thermogenesis by skeletal muscle

Cooke

2011

Biophys Rev

133

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Resting skeletal muscle is a major contributor to adaptive thermogenesis, i.e., the thermogenesis that changes in response to exposure to cold or to overfeeding. The identification of the “furnace” that is responsible for increased heat generation in resting muscle has been the subject of a number of investigations. A new state of myosin, the super relaxed state (SRX), with a very slow ATP turnover rate has recently been observed in skeletal muscle (Stewart et al. in Proc Natl Acad Sci USA 107:430–435, 2010). Inhibition of the myosin ATPase activity in the SRX was suggested to be caused by binding of the myosin head to the core of the thick filament in a structural motif identified earlier by electron microscopy. To be compatible with the basal metabolic rate observed in vivo for resting muscle, most myosin heads would have to be in the SRX. Modulation of the population of this state, relative to the normal relaxed state, was proposed to be a major contributor to adaptive thermogenesis in resting muscle. Transfer of only 20% of myosin heads from the SRX into the normal relaxed state would cause muscle thermogenesis to double. Phosphorylation of the myosin regulatory light chain was shown to transfer myosin heads from the SRX into the relaxed state, which would increase thermogenesis. In particular, thermogenesis by myosin has been proposed to play a role in the dissipation of calories during overfeeding. Up-regulation of muscle thermogenesis by pharmaceuticals that target the SRX would provide new approaches to the treatment of obesity or high blood sugar levels.

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Role of beta adrenoceptors in metabolic and cardiovascular responses of cold exposed humans

Cited by 27 publications

References 22 publications

Body surface temperature adaptations after ice-cold water immersion in regular winter swimmers

Body surface temperature adaptations after ice-cold water immersion in regular winter swimmers

Modulation of adrenergic receptors and adrenergic functions in cold adapted humans

The role of the myosin ATPase activity in adaptive thermogenesis by skeletal muscle

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