Role of Bed Nucleus of the Stria Terminalis Corticotrophin-Releasing Factor Receptors in Frustration Stress-Induced Binge-Like Palatable Food Consumption in Female Rats with a History of Food Restriction

Rationale The interaction between dieting and stress is a key factor for triggering binge episodes on palatable food in human binge eaters. Corticotropin releasing factor (CRF) mechanisms are known to play a pivotal role in the regulation of this maladaptive behavior. Objective The present study evaluated the effect of systemic injection of the CRF1 receptor antagonist R121919, the corticosterone synthesis inhibitor metyrapone and central amygdala (CeA) injections of the nonselective CRF antagonist D-Phe-CRF(12– 41) in rats in which binge eating was evoked by stress and cycles of food restriction. Method Female rats were subjected or not to repeated cycles of regular chow food restriction/refeeding during which they were also given limited access (2 h) to palatable food. On the test day, rats were either exposed or not to the sight of the palatable food for 15 min without allowing access, before assessing food consumption. Results Systemic injections of R121919, but not of the metyrapone, blocked binge-like eating behavior. Restricted and stressed rats showed up-regulation of crh1 receptor mRNA signal in the bed nucleus of the stria terminalis and CeA but not in basolateral amygdala (BLA) or in the paraventricular nucleus. Injection D-Phe-CRF(12– 41) in CeA but not in the BLA blocked binge-like eating behavior. Discussion These findings demonstrate that extra-hypothalamic CRF1 receptors, rather than those involved in endocrine functions, are involved in binge eating and the crucial role of CRF receptors in CeA. CRF1 receptor antagonism may represent a novel pharmacological treatment for binge-related eating disorders.

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“…These compounds did not affect palatable food intake in control rats (Micioni Di Bonaventura et al, 2014). …”

Section: Discussionmentioning

confidence: 89%

“…We recently reported that systemic injections of the CRF1 receptor antagonist R121919 and bed nucleus of the stria terminalis (BNST) injections of the CRF receptor antagonist D-Phe-CRF (12–41) decreased frustration stress-induced binge eating in rats with a history of food restriction (Micioni Di Bonaventura et al, 2014). …”

mentioning

confidence: 99%

Hypothalamic CRF1 receptor mechanisms are not sufficient to account for binge‐like palatable food consumption in female rats

Bonaventura

Ubaldi

Giusepponi

et al. 2017

Intl J Eating Disorders

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“…It is characterized by excessive consumption of highly palatable foods within short periods of time, accompanied by loss of control over eating (American Psychiatric Association, 2013). An increasing number of behavioral and neurobiological findings provide strong support for the consideration of binge eating disorder as an addiction-like disorder (Colantuoni et al, 2002; Corwin & Buda-Levin, 2004; Cottone, Sabino, Steardo, & Zorrilla, 2008; Micioni Di Bonaventura et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

Seeking behavior, place conditioning, and resistance to conditioned suppression of feeding in rats intermittently exposed to palatable food.

Velázquez-Sánchez¹,

Santos²,

Smith³

et al. 2015

Behavioral Neuroscience

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Binge eating disorder is characterized by excessive consumption of highly palatable food within short periods of time accompanied by loss of control over eating. Extensive evidence provides support for the consideration of binge eating disorder as an addiction-like disorder. In this study, we wanted to determine whether rats undergoing an operant binge-like eating procedure could develop maladaptive forms of conditioned feeding behaviors. For this purpose, we trained male rats to self-administer either a sugary, highly palatable diet (Palatable rats) or a chow diet (Chow rats) for 1 hour a day. Following escalation and stabilization of palatable food intake, we tested Chow and Palatable rats in i) a conditioned place preference test, ii) a second-order schedule of reinforcement, and iii) a cue-induced suppression of feeding test. In the conditioned place preference task, Palatable rats spent significantly more time in the compartment that was previously paired with the palatable food, compared to Chow controls. Furthermore, in the second order schedule of reinforcement task, Palatable rats exhibited active lever responding 4- to 6-fold higher than Chow control rats. Finally, in the cue-induced suppression of feeding test, while Chow control subjects reduced responding by 32% in the presence of the conditioned punishment, Palatable rats persevered in responding despite the aversive cue. These results further characterize this animal model of binge-like eating and provide additional evidence for the addictive properties of highly palatable food.

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“…Core diagnostic criteria for binge-eating disorder include excessive consumption of food within brief periods of time, accompanied by loss of control, uncomfortable fullness, and intense feelings of disgust and embarrassment (APA, 2013). Growing evidence suggests that binge eating may result from neuroadaptative mechanisms in discrete areas of the brain that parallel drug and alcohol addiction (Avena et al, 2008;Corwin, 2006;Cottone et al, 2008b;Micioni Di Bonaventura et al, 2014;Parylak et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The Uncompetitive N-methyl-D-Aspartate Antagonist Memantine Reduces Binge-Like Eating, Food-Seeking Behavior, and Compulsive Eating: Role of the Nucleus Accumbens Shell

Smith

Rao

Velázquez-Sánchez

et al. 2014

Neuropsychopharmacol

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Binge-eating disorder is characterized by excessive, uncontrollable consumption of palatable food within brief periods of time. The role of the glutamatergic N-methyl-D-aspartate (NMDA) receptor system in hedonic feeding is poorly understood. The aim of this study was to characterize the effects of the uncompetitive NMDA receptor antagonist memantine on palatable food-induced behavioral adaptations using a rat model, which mimics the characteristic symptomatology observed in binge-eating disorder. For this purpose, we allowed male Wistar rats to respond to obtain a highly palatable, sugary diet (Palatable group) or a regular chow diet (Chow control group), for 1 h a day, under a fixed-ratio 1 (FR1) schedule of reinforcement. Upon stabilization of food responding, we tested the effects of memantine on the Chow and Palatable food groups' intake. Then, we tested the effects of memantine on food-seeking behavior, under a second-order schedule of reinforcement. Furthermore, we investigated the effects of memantine on the intake of food when it was offered in an aversive, bright compartment of a light/dark conflict test. Finally, we evaluated the effects of memantine on FR1 responding for food, when microinfused into the nucleus accumbens (NAcc) shell or core. Memantine dose-dependently decreased binge-like eating and fully blocked food-seeking behavior and compulsive eating, selectively in the Palatable food group. The drug treatment did not affect performance of the control Chow food group. Finally, intra-NAcc shell, but not core, microinfusion of memantine decreased binge-like eating. Together, these findings substantiate a role of memantine as a potential pharmacological treatment for binge-eating disorder.

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Role of Bed Nucleus of the Stria Terminalis Corticotrophin-Releasing Factor Receptors in Frustration Stress-Induced Binge-Like Palatable Food Consumption in Female Rats with a History of Food Restriction

Cited by 64 publications

References 75 publications

Hypothalamic CRF1 receptor mechanisms are not sufficient to account for binge‐like palatable food consumption in female rats

Hypothalamic CRF1 receptor mechanisms are not sufficient to account for binge‐like palatable food consumption in female rats

Seeking behavior, place conditioning, and resistance to conditioned suppression of feeding in rats intermittently exposed to palatable food.

The Uncompetitive N-methyl-D-Aspartate Antagonist Memantine Reduces Binge-Like Eating, Food-Seeking Behavior, and Compulsive Eating: Role of the Nucleus Accumbens Shell

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