Abstract:AimsCorni Fructus (CF) and some CF‐contained prescriptions are commonly used in clinical treatment of depression. This investigation aims to evaluate the main active compound of CF in antidepressant properties and its key target.MethodsFirstly, this study established a behavioral despair model and used high‐performance liquid chromatography method to evaluate the antidepressant‐like effects of water extract, 20%, 50%, and 80% ethanol extracts of CF, and its main active compound. Then, this study created chroni… Show more
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