Role of Baroreceptors in the Zone of Vertebral Arteries in the Reflex Regulation of Venous Tone in the Splanchnic Basin

Kupriyanov, Sergey

doi:10.1007/s10517-009-0635-7

Cited by 5 publications

(6 citation statements)

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“…Authors typically cite the central tendency of these waves to range between 0.025 and 0.075 Hz (∼0.01 to <0.1 Hz) (Seydnejad and Kitney, 2001). Jacob et al (1995) conducted time epoch and frequency "kernel-binned" Wigner-Ville distribution time frequency spectral representations of arterial pressure spectra in ketamine acepromazine maleate-anesthetized rats to reveal a spectral band in arterial pressure waveform exhibiting a frequency approximating 0.05 Hz (see Marchenko and Rogers, 2006a,b, 2007, 2009Marchenko et al, 2012;Ghali and Marchenko, 2013), analogous with the central tendency of the frequency of the spectral band generated by vasogenic autorhythmicity (Barcroft and Nisimaru, 1932;Siegel et al, 1976Siegel et al, , 1984Nisimaru, 1984;Fuji et al, 1990;Ursino et al, 1992). Spectra of cerebral hemodynamics and oxygenation indices in human subjects exhibit Mayer waves with a central frequency tending toward 0.1 Hz (Yucel et al, 2016).…”

Section: Neuronally Conveyed Arteriolar Oscillations May Generate Maymentioning

confidence: 99%

“…Laudable persistence of oscillations exhibiting a central frequency downshifted from Mayer waves and consistent with very low frequency oscillations of vasogenic autorhythmicity successive to cervicomedullary transection ( Montano et al, 2000 ) somewhat undermines the merit of the preceding set of suppositions. Nevertheless, innervation of extra-sinoaortic baroreceptors, present in medial proximal internal carotid, subclavian ( Chevalier-Cholat and Friggi, 1976a , b ), and vertebral ( Kupriyanov, 2009 ) arteries conveyed via axons not transmitted in the vagus or glossopharyngeus nerves would experimentally validate and substantiate the conjecture interactions amongst interneuronal microcircuit oscillators residing within the bulb and spinal cord (see Montano et al, 1995 , 1996 ), rhythmically fluctuating dynamic baroreceptor cell spiking (see Cerutti et al, 1991b , 1994 ; Julien, 2006 ), and oscillations of arteriolar diameter ( Barcroft and Nisimaru, 1932 ; Nisimaru, 1984 ; Siegel et al, 1984 ; Fuji et al, 1990 ; Ursino et al, 1992 ) generate Mayer waves by amplifying pseudo-harmonics of integratively summated out-of-phase very low frequency oscillations ( Martín et al, 1981 ; Vanni et al, 2010 ).…”

Section: Baroreflex Mechanisms Modulate Mayer Wave Propertiesmentioning

confidence: 99%

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RETRACTED: Mechanisms Contributing to the Generation of Mayer Waves

Ghali

2020

Front. Neurosci.

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Mayer waves may synchronize overlapping propriobulbar interneuronal microcircuits constituting the respiratory rhythm and pattern generator, sympathetic oscillators, and cardiac vagal preganglionic neurons. Initially described by Sir Sigmund Mayer in the year 1876 in the arterial pressure waveform of anesthetized rabbits, authors have since extensively observed these oscillations in recordings of hemodynamic variables, including arterial pressure waveform, peripheral resistance, and blood flow. Authors would later reveal the presence of these oscillations in sympathetic neural efferent discharge and brainstem and spinal zones corresponding with sympathetic oscillators. Mayer wave central tendency proves highly consistent within, though the specific frequency band varies extensively across, species. Striking resemblance of the Mayer wave central tendency to the species-specific baroreflex resonant frequency has led the majority of investigators to comfortably presume, and generate computational models premised upon, a baroreflex origin of these oscillations. Empirical interrogation of this conjecture has generated variable results and derivative interpretations. Sinoaortic denervation and effector sympathectomy variably reduces or abolishes spectral power contained within the Mayer wave frequency band. Refractorines of Mayer wave generation to barodeafferentation lends credence to the hypothesis these waves are chiefly generated by brainstem propriobulbar and spinal cord propriospinal interneuronal microcircuit oscillators and likely modulated by the baroreflex. The presence of these waves in unitary discharge of medullary lateral tegmental field and rostral ventrolateral medullary neurons (contemporaneously exhibiting fast sympathetic rhythms [2–6 and 10 Hz bands]) in spectral variability in vagotomized pentobarbital-anesthetized and unanesthetized midcollicular (i.e., intercollicular) decerebrate cats supports genesis of Mayer waves by supraspinal sympathetic microcircuit oscillators. Persistence of these waves following high cervical transection in vagotomized unanesthetized midcollicular decerebrate cats would seem to suggest spinal sympathetic microcircuit oscillators generate these waves. The widespread presence of Mayer waves in brainstem sympathetic-related and non-sympathetic-related cells would seem to betray a general tendency of neurons to oscillate at this frequency. We have thus presented an extensive and, hopefully cohesive, discourse evaluating, and evolving the interpretive consideration of, evidence seeking to illumine our understanding of origins of, and insight into mechanisms contributing to, the genesis of Mayer waves. We have predicated our arguments and conjectures in the substance and matter of empirical data, though we have occasionally waxed philosophical beyond these traditional confines in suggesting interpretations exceeding these limits. We believe our synthesis and interpretation of the relevant literature will fruitfully inspire future studies from the perspective of a more intimate appreciation and conceptualization of network mechanisms generating oscillatory variability in neuronal and neural outputs. Our evaluation of Mayer waves informs a novel set of disciplines we term quantum neurophysics extendable to describing subatomic reality. Beyond informing our appreciation of mechanisms generating sympathetic oscillations, Mayer waves may constitute an intrinsic property of neurons extant throughout the cerebrum, brainstem, and spinal cord or reflect an emergent property of interactions between arteriogenic and neuronal oscillations.

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Section: Neuronally Conveyed Arteriolar Oscillations May Generate Maymentioning

confidence: 99%

Section: Baroreflex Mechanisms Modulate Mayer Wave Propertiesmentioning

confidence: 99%

RETRACTED: Mechanisms Contributing to the Generation of Mayer Waves

Ghali

2020

Front. Neurosci.

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“…to elicit sinoatrial deceleration and corrective attenuation of arteriolar and venular tone via enhanced oscillatory baroreceptor spiking frequency, coordinated by reductions in the sympathetic drive to the heart and vessels and increases of ambiguual cardiovagal premotoneuronal drive to electroconductive circuitry of the heart and atrial myocardium (Rogers et al, 2000). Baroreceptors sensitive to dynamic arterial stretch are most densely located within the aortic arch and carotid sinus, though may be found sparsely distributed throughout middle internal carotid (Toorop et al, 2013), vertebral (Agadzhanian and Kupriianov, 2008;Kupriyanov, 2009), and subclavian arteries Friggi, 1977, 1976;Kidd et al, 1974). Baroreceptor and baroafferent discharge frequency covary with dynamic arterial pressure magnitude.…”

Section: Respiratory Gating Of Baromodulation Of Sympathetic Oscillatmentioning

confidence: 99%

“…thorespiratory coupling. Oscillatory baroreceptor inputs transduced by pressure-sensitive receptors exhibiting highest density within the carotid sinus and aortic arch, though diffusely distributed throughout the internal carotid (Toorop et al, 2013), vertebral (Agadzhanian and Kupriianov, 2008;Kupriyanov, 2009), and subclavian arteries Friggi, 1977, 1976;Kidd et al, 1974) relays centrally to neurons residing within the medial and interstitial divisions of the nucleus tractus solitarius covarying dynamically with changes of arterial pressure magnitude (Rogers et al, 2000). Spatiotemporal bursting dynamics of integrated baroreceptor discharge frequency assumes the form of a sine wave.…”

Section: Perspectives and Significancementioning

confidence: 99%

Mechanisms underlying the generation of autonomorespiratory coupling amongst the respiratory central pattern generator, sympathetic oscillators, and cardiovagal premotoneurons

Ghali¹,

Ghali²,

Lima³

et al. 2020

Journal of Integrative Neuroscience

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The respiratory rhythm and pattern and sympathetic and parasympathetic outflows are generated by distinct, though overlapping, propriobulbar arrays of neuronal microcircuit oscillators constituting networks utilizing mutual excitatory and inhibitory neuronal interactions, residing principally within the metencephalon and myelencephalon, and modulated by synaptic influences from the cerebrum, thalamus, hypothalamus, cerebellum, and mesencephalon and ascending influences deriving from peripheral stimuli relayed by cranial nerve afferent axons. Though the respiratory and cardiovascular regulatory effector mechanisms utilize distinct generators, there exists significant overlap and interconnectivity amongst and between these oscillators and pathways, evidenced reciprocally by breathing modulation of sympathetic oscillations and sympathetic modulation of neural breathing. These coupling mechanisms are well-demonstrated coordinately in sympatheticand respiratory-related central neuronal and efferent neurogram recordings and quantified by the findings of crosscorrelation, spectra, and coherence analyses, combined with empirical interventions including lesioning and pharmacological agonist and antagonist microinjection studies, baroloading, barounloading, and hypoxic and/or hypercapnic peripheral and/or central chemoreceptor stimulation. Sympathetic and parasympathetic central neuronal and efferent neural discharge recordings evidence classic fast rhythms produced by propriobulbar neuronal networks located within the medullary division of the lateral tegmental field, coherent with cardiac sympathetic nerve discharge. These neural efferent nerve discharges coordinately evidence slow synchronous oscillations, constituted by Traube Hering (i.e., high frequency), Mayer wave (i.e., medium or low frequency), and vasogenic autorhythmicity (i.e., very low frequency) wave spectral bands. These oscillations contribute to coupling neural breathing, sympathetic oscillations, and parasympathetic cardiovagal premotoneuronal activity. The mechanisms underlying the origins of and coupling amongst, these waves remains to be unresolved.

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“…In our laboratory, based on experiments on cats and clinical studies on pregnant women, cardiorespiratory indicators were developed, which we described in early publications (16,(20)(21)(22). Yu.S.…”

Section: Introductionmentioning

confidence: 99%

Cardiopulmonary Index of Organism Adaptation to Low Physical Exercises of Increasing Power

et al. 2020

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Objective. The main purpose of the research was to develop a coefficient of cardiorespiratory system status, which will take into account both frequency and power characteristics of external respiration and hemodynamics activity. Compare an informativeness of this coefficient with a universally accepted Hildebrandt one.Materials and Methods. 154 apparently healthy young people of both sexes were examined. On a bicycle ergometer with a pedaling rhythm of 40 per minute, five standard stages of short-term physical exercise load ranging from negligible to moderate were provided. Spirography, tonometry and pulsometry were carried out before loading, at its peak and after it. The parameters specified were recorded for each subject simultaneously. Systolic volume was calculated using Starr formula with subsequent defining cardiac minute output.Statistical analysis was performed using Statistica ® 7.0 package (StatSoft Inc., USA). Assessment of results' significance was calculated using Student's t-test and sign test.Results. In the case of low short-term physical exercises pulmonary ventilation is increased due to greater reactivity of external breathing amplitude and to a lesser extent due to change in the frequency of respiratory movements. This type of reactions of the respiratory component in cardiorespiratory interaction is more efficient. In the given conditions, body's adaptation is ensured by breathing component dominance, while responses of systemic arterial pressure and pulse turn out to be less pronounced, less stabile. Taking into account greater adaptive importance in power characteristics changes of respiratory and cardiovascular activity, a coefficient of cardiorespiratory system status is proposed -MBV/RMV (ratio of minute blood flow volume to respiratory minute volume). The given factor is demonstrated to have significantly greater informative value and sensitivity to generally recognized Hildebrandt coefficient.

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Role of Baroreceptors in the Zone of Vertebral Arteries in the Reflex Regulation of Venous Tone in the Splanchnic Basin

Cited by 5 publications

References 5 publications

RETRACTED: Mechanisms Contributing to the Generation of Mayer Waves

RETRACTED: Mechanisms Contributing to the Generation of Mayer Waves

Mechanisms underlying the generation of autonomorespiratory coupling amongst the respiratory central pattern generator, sympathetic oscillators, and cardiovagal premotoneurons

Cardiopulmonary Index of Organism Adaptation to Low Physical Exercises of Increasing Power

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