Role of bacteria in the pathogenesis of short bowel syndrome-associated D-lactic acidemia

Bongaerts, G.P.A.; Tolboom, J.J.M.; Naber, A.H.J.; Sperl, Wolfgang; Severijnen, R.S.V.M.; Bakkeren, J. A. J. M.; Willems, J. L.

doi:10.1006/mpat.1996.0122

Cited by 101 publications

(64 citation statements)

References 16 publications

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“…Recently, data are accumulating to suggest that the most common association with SIBO is IBS and bacterial overgrowth may be part of the [Bongaerts et al 1997] pathogenesis of this condition [Pimentel et al 2006;Fumi and Trexler, 2008]. In addition, SIBO has been reported with rosacea, a dermatological skin condition affecting the face .…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance

Sachdev

Pimentel

2013

Therapeutic Advances in Chronic Disease

151

133

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Small intestinal bacterial overgrowth (SIBO) is defined as the presence of an abnormally high number of coliform bacteria in the small bowel. It is associated with a broad range of predisposing small intestinal motility disorders and with surgical procedures that result in bowel stasis. The most common symptoms associated with SIBO include diarrhea, flatulence, abdominal pain and bloating. Quantitative culture of small bowel contents and a variety of indirect tests have been used over the years in an attempt to facilitate the diagnosis of SIBO. The indirect tests include breath tests and biochemical tests based on bacterial metabolism of a variety of substrates. Unfortunately, there is no single valid test for SIBO, and the accuracy of all current tests remains limited due to the failure of culture to be a gold standard and the lack of standardization of the normal bowel flora in the small intestine. Currently, the ideal approach to treat SIBO is to treat the underlying disease, eradicate overgrowth, and address nutritional deficiencies that may be associated with the development of SIBO.

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Section: Clinical Manifestationsmentioning

confidence: 99%

Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance

Sachdev

Pimentel

2013

Therapeutic Advances in Chronic Disease

151

133

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“…Це захворювання частіше зустрі-чається у людей, які страждають від больових колітів короткого кишківника [25]. У пацієнтів з D -лактат ацидозом проявляються неврологічні дисфункції, що характеризуються атаксією, невиразною мовою, га-люцинаціями, сонливістю, незграбністю, млявістю, запамороченням тощо [26]. [27].…”

Section: результати досліджень показників щодо впливуunclassified

Impact of malt extracts on lactobacillus and bifidobacterium in probiotic fermented beverages

Chepel

Koshova

2015

EEJET

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“…They are possibly related to the translocation of intestinal bacteria, since microorganisms that commonly colonize the gastrointestinal tract such as Enterococcus and Escherichia coli have been detected in 13% and 4% of infected catheters, respectively 7 . Studies have also pointed out that bacterial translocation may be a probable route for the occurrence of sepsis/ septic shock [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Cyclic parenteral nutrition does not change the intestinal microbiota in patients with short bowel syndrome

Furtado¹,

Marchini

Fonseca³

et al. 2013

Acta Cir. Bras.

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(FMRP-USP). Ribeirão Preto -SP, Brazil. Responsible for study design, intellectual and scientific content, and use of the English language during drafting of the manuscript. ABSTRACT PURPOSE:To characterize of the intestinal microbiota of patients with short bowel syndrome (SBS) admitted to the Metabolic Unit of a University Hospital. METHODS:Fecal samples were evaluated, and biochemical tests were conducted only in the case of SBS patients. The nutritional status was assessed via anthropometric measurements and evaluation of food intake by means of a food questionnaire. The pathogenic strains were detected with the aid of cultures and specific biochemical tests in aerobic medium, for determination of species belonging to the Family enterobacteriaceae. Anti-sera were applied to each isolated E. coli strain, for determination of their possible pathogenicity.Molecular methodology was employed for establishment of the intestinal bacterial microbiota profile. RESULTS:A lower amount of microorganisms of the family enterobacteriaceae per gram of stool was observed in the case of patients with SBS. However, molecular analysis showed maintenance of the bacterial species ratio, which is equivalent to a healthy intestinal microbiota. CONCLUSION:Despite the massive removal of the small bowel, frequent use of antibiotics, immune system depression, presence of non-digested food in the gastrointestinal tract, and accelerated intestinal transit, the ratio between intestinal bacterial species remain similar to normality.

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Role of bacteria in the pathogenesis of short bowel syndrome-associated D-lactic acidemia

Cited by 101 publications

References 16 publications

Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance

Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance

Impact of malt extracts on lactobacillus and bifidobacterium in probiotic fermented beverages

Cyclic parenteral nutrition does not change the intestinal microbiota in patients with short bowel syndrome

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