Role of B Cells and Antibodies in Acquired Immunity against Mycobacterium tuberculosis

Achkar, Jacqueline M.; Chan, John; Casadevall, Arturo

doi:10.1101/cshperspect.a018432

Cited by 45 publications

(63 citation statements)

References 227 publications

(359 reference statements)

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“…The host-pathogen interactions of other intracellular organisms demonstrate similar findings [71]. Antibodies against the surface of Histoplasma capsulatum are protective in mouse models but these proteins are not strongly immunogenic as evidenced by the finding that passive transfer of immune serum has no effect in models of lethal histoplasmosis [72].…”

Section: Introductionmentioning

confidence: 65%

Antibodies and tuberculosis

et al. 2016

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SummaryTuberculosis (TB) remains a major public health problem internationally, causing 9.6 million new cases and 1.5 million deaths worldwide in 2014. The Bacillus Calmette-Guérin vaccine is the only licensed vaccine against TB, but its protective effect does not extend to controlling the development of infectious pulmonary disease in adults. The development of a more effective vaccine against TB is therefore a pressing need for global health. Although it is established that cell-mediated immunity is necessary for the control of latent infection, the presupposition that such immunity is sufficient for vaccine-induced protection has recently been challenged. A greater understanding of protective immunity against TB is required to guide future vaccine strategies against TB.In contrast to cell-mediated immunity, the human antibody response against M.tb is conventionally thought to exert little immune control over the course of infection. Humoral responses are prominent during active TB disease, and have even been postulated to contribute to immunopathology. However, there is evidence to suggest that specific antibodies may limit the dissemination of M.tb, and potentially also play a role in prevention of infection via mucosal immunity. Further, antibodies are now understood to confer protection against a range of intracellular pathogens by modulating immunity via Fc-receptor mediated phagocytosis. In this review, we will explore the evidence that antibody-mediated immunity could be reconsidered in the search for new vaccine strategies against TB.

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Section: Introductionmentioning

confidence: 65%

Antibodies and tuberculosis

et al. 2016

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“…In this study, we showed that the persistence of BALT increased protection from reactivation. Although the precise role of B cells in TB infection control remains to be determined, existing evidence suggests that B cells are required for optimal development of immune responses against Mtb (15,16,41). Moreover, the presence of tingible body macrophages in BALT suggests that B cells are undergoing affinity maturation or that cross-priming of CD8 + T cells occurs within these lymphoid follicles, allowing site-directed activation of macrophages (33,35,42,43).…”

Section: Discussionmentioning

confidence: 99%

CD4 ⁺ T-cell–independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection

Foreman

Mehra

LoBato

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

121

202

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The synergy between Mycobacterium tuberculosis (Mtb) and HIV in coinfected patients has profoundly impacted global mortality because of tuberculosis (TB) and AIDS. HIV significantly increases rates of reactivation of latent TB infection (LTBI) to active disease, with the decline in CD4 + T cells believed to be the major causality. In this study, nonhuman primates were coinfected with Mtb and simian immunodeficiency virus (SIV), recapitulating human coinfection. A majority of animals exhibited rapid reactivation of Mtb replication, progressing to disseminated TB and increased SIV-associated pathology. Although a severe loss of pulmonary CD4 + T cells was observed in all coinfected macaques, a subpopulation of the animals was still able to prevent reactivation and maintain LTBI. Investigation of pulmonary immune responses and pathology in this cohort demonstrated that increased CD8 + memory T-cell proliferation, higher granzyme B production, and expanded B-cell follicles correlated with protection from reactivation. Our findings reveal mechanisms that control SIV-and TB-associated pathology. These CD4-independent protective immune responses warrant further studies in HIV coinfected humans able to control their TB infection. Moreover, these findings will provide insight into natural immunity to Mtb and will guide development of novel vaccine strategies and immunotherapies.Nonhuman primate | B cells | tuberculosis | CD4 T cells | CD8 T cells

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“…Although antibody alone is certainly not sufficient, it may well be necessary’, at least in some hosts. While cell‐mediated immune mechanisms, predominantly based on T cells and mononuclear phagocytes, are the cornerstone in the defense against Mtb at most stages of the infection (reviewed in ), increasing evidence over the past years suggests that innate and humoral immunity also play a role (reviewed in ). Furthermore, the interactions and complementing effects between the different arms of the immune system will likely be needed for optimal protection against infection and development of disease.…”

Section: Introductionmentioning

confidence: 99%

B cells and antibodies in the defense against Mycobacterium tuberculosis infection

Achkar

Chan

Casadevall

2015

Immunological Reviews

159

110

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Summary Better understanding of the immunological components and their interactions necessary to prevent or control Mycobacterium tuberculosis (Mtb) infection in humans is critical for tuberculosis (TB) vaccine development strategies. While the contributory role of humoral immunity in the protection against Mtb infection and disease is less defined than the role of T cells, it has been well established for many other intracellular pathogens. Here we update and discuss the increasing evidence and the mechanisms of B cells and antibodies in the defense against Mtb infection. We posit that B cells and antibodies have a variety of potential protective roles at each stage of Mtb infection, and postulate that such roles should be considered in the development strategies for TB vaccines and other immune-based interventions.

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Role of B Cells and Antibodies in Acquired Immunity against Mycobacterium tuberculosis

Cited by 45 publications

References 227 publications

Antibodies and tuberculosis

Antibodies and tuberculosis

CD4 ⁺ T-cell–independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection

B cells and antibodies in the defense against Mycobacterium tuberculosis infection

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Role of B Cells and Antibodies in Acquired Immunity against Mycobacterium tuberculosis

Cited by 45 publications

References 227 publications

Antibodies and tuberculosis

Antibodies and tuberculosis

CD4 + T-cell–independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection

B cells and antibodies in the defense against Mycobacterium tuberculosis infection

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CD4 ⁺ T-cell–independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection