Role of Autologous Bone Marrow Mononuclear Cells in Chronic Cervical Spinal Cord Injury-A Longterm Follow Up Study

Adverse events of cell therapy clinical trials in human chronic spinal cord injury, a systematic review and meta-analysis

“…In 76 reviewed articles with 1633 cases and 189 controls, 64 types of AEs were recorded in 45 studies ( Appendix 1 ). The AEs were reported after cell therapy with BM-MSC in 12 studies [ [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] ], BM-HSC in 7 studies [ [18] , [19] , [20] , [21] , [22] , [23] , [24] ], OEC in 6 studies [ [25] , [26] , [27] , [28] , [29] , [30] ], NSC in 4 studies [ [31] , [32] , [33] , [34] ], UC-MSC in 3 studies [ [35] , [36] , [37] ], PB-HSC in 3 studies [ [38] , [39] , [40] ], A-MSC cells in 2 studies [ 41 , 42 ], and SC& BM-MSC in 2 studies [ [ 43 , 44 ]). In six types of cell therapies, AE was reported only in one study (SC [ 45 ], ESC [ 46 ], UCB-HSC [ 47 ], OEC& BM-MSC [ 48 ], OEC& BM-HSC [ 49 ], PB-HSC& A-MSC [ 50 ]) ( Fig.…”

“…The most common AE in the gastrointestinal system was Nausea and vomiting in 5 studies (with BM-HSC cells: 1 patient, p = 0.16 [ 19 , 21 ], ESC: 2 patients, p = 0.008 [ 46 ], A-MSC: 1 patient, p = 0.09 [ 41 ], and BM-MSC: 3 patients, p = 0.27 [ 12 ]). We meta-analyzed 6 cell types that had gastrointestinal AEs.…”