Role of Atrial Natriuretic Peptide in Interleukin 1.BETA.-Induced Natriuresis in Conscious Rats.

Funyu, Takeharu; Kimura, Tokihisa; Yamamoto, Takeki; Ota, Kozo; Miyake, Shoji; Ohta, Makoto; Sato, Kazutoshi; Abe, Keishi

doi:10.1620/tjem.177.73

Cited by 2 publications

(2 citation statements)

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“…(21) The observed effect of IL-1b on intestinal and renal ATPases may be direct or indirect and could be mediated through the release of other cytokines or hormones that are themselves responsible for the ultimate IL-1b action. For example, Funyu et al (22) have attributed the natriuresis induced by IL-b to an increase in the level of atrial natriuretic peptide. Because the latter is known to modulate the activity of many transporters, including Na 1 /K 1 -ATPase, (23) it could be a mediator in the IL-1b effect on the pump.…”

Section: A B Cmentioning

confidence: 99%

Interleukin-1βIncreases Urine Flow Rate and Inhibits Protein Expression of Na⁺/K⁺-ATPase in the Rat Jejunum and Kidney

Kreydiyyeh

Al–Sadi

2002

Journal of Interferon & Cytokine Research

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The effect of interleukin-1beta (IL-1beta) on urine flow rates and Na(+)/K(+)-ATPase activity and expression was studied in rat intestinal and renal epithelia. The cytokine produced a significant diuretic effect and increased urine flow rate by around 10-fold compared with the control. This effect was considered to be secondary to the well-documented natriuretic effect of the cytokine described in the literature. On the other hand, we have shown previously that IL-1beta inhibits glucose absorption from the jejunum. As sodium excretion and glucose absorption are both dependent on Na(+)/K(+)-ATPase activity, the effect of the cytokine on the renal and intestinal pump was investigated. IL-1beta inhibited, in a dose-dependent manner, the activity of Na(+)/K(+)-ATPase in villus and crypt jejunal cells and in medullary and cortical kidney cells. Western blot analysis revealed a decrease in the protein expression of the enzyme, which was confirmed by the radiolabeled ouabain binding assay. The results suggest that the diuretic and natriuretic effect of IL-1beta and its inhibitory effect on glucose absorption are all due to downregulation of the Na(+)/K(+) pump in the kidney and jejunum.

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Section: A B Cmentioning

confidence: 99%

Interleukin-1βIncreases Urine Flow Rate and Inhibits Protein Expression of Na⁺/K⁺-ATPase in the Rat Jejunum and Kidney

Kreydiyyeh

Al–Sadi

2002

Journal of Interferon & Cytokine Research

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“…Fever in mammals is associated with changes in the circulating concentrations of a number of hormones including thyroid hormones, cortisol, atrial natriuretic peptide and arginine vasopressin (Riedel et al 1986; Funyu et al 1995; Keil et al 1996). Arginine vasopressin (AVP) is thought to be particularly important and is a strong candidate for having a role as an endogenous cryogen (Hellon et al 1991; Kluger, 1991).…”

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confidence: 99%

Antidiuretic hormone and angiotensin II plasma concentrations in febrile Pekin ducks

Gray

Maloney

1998

The Journal of Physiology

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Simultaneous whole‐cell voltage and Ca2+ fluorescence measurements were made from the distal apical dendrites and the soma of thick tufted pyramidal neurons in layer 5 of 4‐week‐old (P28–32) rat neocortex slices to investigate whether activation of distal synaptic inputs can initiate regenerative responses in dendrites. Dual whole‐cell voltage recordings from the distal apical trunk and primary tuft branches (540–940 μm distal to the soma) showed that distal synaptic stimulation (upper layer 2) evoking a subthreshold depolarization at the soma could initiate regenerative potentials in distal branches of the apical tuft which were either graded or all‐or‐none. These regenerative potentials did not propagate actively to the soma and axon. Calcium fluorescence measurements along the apical dendrites indicated that the regenerative potentials were associated with a transient increase in the concentration of intracellular free calcium ([Ca2+]i) restricted to distal dendrites. Cadmium added to the bath solution blocked both the all‐or‐none dendritic regenerative potentials and local dendritic [Ca2+]i transients evoked by distal dendritic current injection. Thus, the regenerative potentials in distal dendrites represent local Ca2+ action potentials. Initiation of distal Ca2+ action potentials by a synaptic stimulus required coactivation of AMPA‐ and NMDA‐type glutamate receptor channels. It is concluded that in neocortical layer 5 pyramidal neurons of P28–32 animals glutamatergic synaptic inputs to the distal apical dendrites can be amplified via local Ca2+ action potentials which do not reach threshold for axonal AP initiation. As amplification of distal excitatory synaptic input is associated with a localized increase in [Ca2+]i these Ca2+ action potentials could control the synaptic efficacy of the distal cortico‐cortical inputs to layer 5 pyramidal neurons.

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Role of Atrial Natriuretic Peptide in Interleukin 1.BETA.-Induced Natriuresis in Conscious Rats.

Cited by 2 publications

References 21 publications

Interleukin-1βIncreases Urine Flow Rate and Inhibits Protein Expression of Na⁺/K⁺-ATPase in the Rat Jejunum and Kidney

Interleukin-1βIncreases Urine Flow Rate and Inhibits Protein Expression of Na⁺/K⁺-ATPase in the Rat Jejunum and Kidney

Antidiuretic hormone and angiotensin II plasma concentrations in febrile Pekin ducks

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Role of Atrial Natriuretic Peptide in Interleukin 1.BETA.-Induced Natriuresis in Conscious Rats.

Cited by 2 publications

References 21 publications

Interleukin-1βIncreases Urine Flow Rate and Inhibits Protein Expression of Na+/K+-ATPase in the Rat Jejunum and Kidney

Interleukin-1βIncreases Urine Flow Rate and Inhibits Protein Expression of Na+/K+-ATPase in the Rat Jejunum and Kidney

Antidiuretic hormone and angiotensin II plasma concentrations in febrile Pekin ducks

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Interleukin-1βIncreases Urine Flow Rate and Inhibits Protein Expression of Na⁺/K⁺-ATPase in the Rat Jejunum and Kidney

Interleukin-1βIncreases Urine Flow Rate and Inhibits Protein Expression of Na⁺/K⁺-ATPase in the Rat Jejunum and Kidney