Role of Atractylenolide I in Cerebral Ischemia Reperfusion Injury

Yu, Ziqiao; Niu, Ping; Su, Zhuoyi; Ma, Chunyu; Wang, Xu; Zhao, Dexi; Zhang, Shuai

doi:10.1007/s43450-023-00386-7

Cited by 1 publication

(2 citation statements)

References 58 publications

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“…Yu et al [ 136 ] discovered that AT-I could alleviate cerebral ischemia/reperfusion injury by reducing apoptosis and inflammatory responses through the inactivation of the nuclear factor-κB pathway. Additionally, AT-I mediated protective effects against acetaminophen-induced hepatotoxicity via the TLR4/MAPKs/NF-κB pathways, which attenuated the APAP-induced activation of TLR4, NF-κB, and MAPKs (including JNK and p38) [ 137 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

“…Guai-10( 14)-en-11-ol (135) was isolated from A. macrocephala rhizomes via silica gel column chromatography; its chemical structure was determined by a combination of 1D and 2D NMR analysis and mass spectrometry [43]. A new guaiane-type sesquiterpene, named seco-guaione (136), was recently isolated from a 95% ethanol extraction of A. lancea using macroporous resin, silica gel, and semi-preparative HPLC, and the chemical structure was identified via physiochemical and spectroscopic evidence [29]. The guaiane-type sesquiterpenoids from genus Atractylodes DC.…”

Section: Guaiane-type Sesquiterpenesmentioning

confidence: 99%

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Phytochemistry and Pharmacology of Sesquiterpenoids from Atractylodes DC. Genus Rhizomes

Qu,

Liu,

Zhang

et al. 2024

Molecules

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The rhizomes of the genus Atractylodes DC. consist of various bioactive components, including sesquiterpenes, which have attracted a great deal of research interest in recent years. In the present study, we reviewed the previously published literatures prior to November 2023 on the chemical structures, biosynthetic pathways, and pharmacological activities of the sesquiterpenoids from this genus via online databases such as Web of Science, Google Scholar, and ScienceDirect. Phytochemical studies have led to the identification of more than 160 sesquiterpenes, notably eudesmane-type sesquiterpenes. Many pharmacological activities have been demonstrated, particularly anticancer, anti-inflammatory, and antibacterial and antiviral activities. This review presents updated, comprehensive and categorized information on the phytochemistry and pharmacology of sesquiterpenes in Atractylodes DC., with the aim of offering guidance for the future exploitation and utilization of active ingredients in this genus.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Section: Guaiane-type Sesquiterpenesmentioning

confidence: 99%