Role of atmospheric pollution on the natural history of idiopathic pulmonary fibrosis

Sesé, Lucile; Nunès, Hilario; Cottin, Vincent; Sanyal, Shreosi; Didier, Morgane; Carton, Zohra; Israël‐Biet, Dominique; Crestani, Bruno; Cadranel, Jacques; Wallaert, B.; Tazi, Abdellatif; Maître, Bernard; Prévôt, Grégoire; Marchand-Adam, S.; Guillot-Dudoret, S.; Nardi, A.; Dury, Sandra; Giraud, Violaine; Gondouin, Anne; Juvin, Karine; Borie, R.; Wislez, Marie; Valeyre, Dominique; Annesi‐Maesano, Isabella

doi:10.1136/thoraxjnl-2017-209967

Cited by 154 publications

(159 citation statements)

References 36 publications

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“…Other studies using Cox proportional hazards model to evaluate the impact of air pollution on acute exacerbation (AE) or disease progression of IPF in longitudinal cohorts identified that onset of AE was significantly associated with antecedent 6-week increases in O 3 concentration [11]. Besides, mortality was significantly associated with increased levels of exposure to PM2.5 and PM10 [12]. Together, these epidemiological studies argue that air pollution has a negative impact on IPF incidence and outcomes; however, the underlying mechanisms that regulate these processes are still being uncovered.…”

Section: Introductionmentioning

confidence: 99%

Particulate Matter Increases the Severity of Bleomycin-Induced Pulmonary Fibrosis through KC-Mediated Neutrophil Chemotaxis

Cheng¹,

Liu

Lin

et al. 2019

IJMS

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Background: Although particular matter (PM) increases incidence and severity of idiopathic pulmonary fibrosis, the underlying mechanism remains elusive. Methods: The effects of PM were evaluated in a murine model of bleomycin-induced pulmonary fibrosis. Mice were divided into four groups, receiving: (1) Saline (control), (2) bleomycin, (3) PM, or (4) bleomycin plus PM (Bleo+PM). Additional groups of Bleo+PM mice were treated with sivelestat (an inhibitor of neutrophil elastase) or reparixin (a C-X-C motif chemokine receptor 2 antagonist), or were genetically modified with keratinocyte chemoattractant (KC) deletion. Results: Pulmonary fibrosis was not observed in the control or PM groups. Bleomycin induced pulmonary fibrosis within 14 days. The Bleo+PM group showed worse pulmonary fibrosis when compared to the bleomycin group. Analyses of immune cell profile and chemokine/cytokine concentrations at day 2-bronchoalveolar lavage fluid (BALF) revealed that the Bleo+PM group had increased neutrophil number and elastase level and KC concentration compared to the bleomycin group. Neutrophil elastase activated the Smad2/Smad3/α-SMA pathway to induce collagen deposition, while sivelestat abrogated the increased severity of pulmonary fibrosis caused by PM. Chemotaxis assay revealed that BALF of the Bleo+PM group recruited neutrophil, which was dependent on KC. Further, genetic KC deletion or pharmaceutical inhibition of KC binding to CXCR2 with reparixin ameliorated the PM-induced increased severity of pulmonary fibrosis. Conclusions: These data provide evidence that the PM-induced increased severity of pulmonary fibrosis depends on KC-mediated neutrophil chemotaxis and give additional mechanic insight that will aid in the development of therapeutic strategies.

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Section: Introductionmentioning

confidence: 99%

Particulate Matter Increases the Severity of Bleomycin-Induced Pulmonary Fibrosis through KC-Mediated Neutrophil Chemotaxis

Cheng¹,

Liu

Lin

et al. 2019

IJMS

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“…The progression of IPF is challenging and hard to foresee, but the slow gait speed in IPF could be a simple, reliable tool that may detect phenotypes associated with a worse clinical outcome. The efforts to better define the risk factors of IPF progression had led to the environmental analysis and a real association with air pollution and long‐term exposure to PM 10 and PM 2.5 linked to an increase of the mortality …”

Section: Idiopathic Pulmonary Fibrosismentioning

confidence: 99%

Contemporary Concise Review 2018: Interstitial lung disease

2019

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“…Following the recent update on acute exacerbation (AEx) of IPF, there have been a number of further publications on the subject . Bronchoscopy assessment of AEx in a retrospective cohort of patients with varied ILD diagnoses did not provide benefit, with a positive yield of 13%, and a change in management in only 4 of 106 patients, while ICU transfer as a result of the procedure occurred in more than half of the patients .…”

Section: Interstitial Lung Diseasementioning

confidence: 99%

Year in review 2017: Interstitial lung disease, pulmonary vascular disease and sleep

et al. 2018

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Role of atmospheric pollution on the natural history of idiopathic pulmonary fibrosis

Abstract: This study suggests that air pollution has a negative impact on IPF outcomes, corroborating the role of ozone on AEs and establishing, for the first time, the potential role of long-term exposure to PM and PM on overall mortality.

Cited by 154 publications

References 36 publications

Particulate Matter Increases the Severity of Bleomycin-Induced Pulmonary Fibrosis through KC-Mediated Neutrophil Chemotaxis

Particulate Matter Increases the Severity of Bleomycin-Induced Pulmonary Fibrosis through KC-Mediated Neutrophil Chemotaxis

Contemporary Concise Review 2018: Interstitial lung disease

Year in review 2017: Interstitial lung disease, pulmonary vascular disease and sleep

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