Role of asymmetric-dimethyl-l-arginine (ADMA) and nitrite/nitrate (NOx) in the pathogenesis of oxidative stress in female subjects with uncomplicated type 1 diabetes mellitus

Pitocco, Dario; Zaccardi, Francesco; Stasio, Enrico Di; Romitelli, Federica; Martini, Francesca; Scaglione, Giovanni Luca; Speranza, Dorina; Santini, Stefano Angelo; Zuppi, Cecilia; Ghirlanda, Giovanni

doi:10.1016/j.diabres.2009.09.019

Cited by 44 publications

(33 citation statements)

References 21 publications

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“…The exact mechanism that causes an increase in NO concentration is not understood. In this study, we showed that a reduced inhibition of NOS could have a relevant role in such a phenomenon, as we found lower levels of ADMA in subjects with diabetic neuropathy than in controls, and a negative correlation with ADMA and NO levels, supporting the biochemical observation of ADMA as an inhibitor of NOS (32). Nitric oxide is a free radical gas molecule which is produced from L-arginine by the catalytic action of enzymes, NOSs.…”

Section: Discussionsupporting

confidence: 52%

Diyabetik nöropatili hastalarında serum asimetrik dimetilarjinin ve nitrik oksit düzeyleri

...

2012

npa

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Re cei ved/Ge liş ta ri hi: 21.07.2011 Ac cep ted/Ka bul ta ri hi: 16.12.2011 © Arc hi ves of Neu ropsy chi atry, pub lis hed by Ga le nos Pub lis hing / © Nö rop si ki yat ri Ar şi vi Der gi si, Ga le nos Ya yı ne vi ta ra f›n dan ba s›l m›fl t›r. ABS TRACTObjective: Asymmetric dimethylarginine (ADMA) is a novel marker of endothelial dysfunction. ADMA is an endothelial nitric oxide synthase inhibitor. Due to scarcity of studies on the role of ADMA in pathogenesis of diabetic neuropathy, it remains to be determined whether blood ADMA and nitric oxide (NO) levels are associated with diabetic neuropathy. In this case control study, we aimed to evaluate the relationship between serum NO and ADMA levels among diabetic neuropathy cases Methods: 48 patients with diabetic neuropathy and 34 healthy subjects were included in the study. All type 2 diabetic patients underwent electrophysiological and neurological examination. NO levels were determined using the Griess method. Serum ADMA levels were determined by using the ELISA method. Results: The serum ADMA levels in diabetic neuropathy patients were found to be statistically significantly lower than those of the control group (p=0.005). However, a statistically significant increase was observed in serum NO levels in patients with diabetic neuropathy compared with those in the control group (p = 0.009). A negative correlation was found between NO levels and ADMA levels (p=0.041, r=-0.23). Discussion: Changes in NO and ADMA levels in the blood of diabetic neuropathy patients may indicate oxidative stress and endothelial dysfunction in the pathogenesis of diabetic neuropathy. (Arc hi ves of Neu ropsy chi atry 2012; 49: 183-187)

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Section: Discussionsupporting

confidence: 52%

Diyabetik nöropatili hastalarında serum asimetrik dimetilarjinin ve nitrik oksit düzeyleri

...

2012

npa

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“…In vivo studies revealed that oxidative stress due to hyperglycemia occurs before late complications become clinically evident [56]. This finding suggests that oxidative stress plays a crucial role in the pathogenesis of late diabetic complications.…”

Section: Human Studiesmentioning

confidence: 82%

“…Remarkably, this marker correlated with blood glucose levels and glucose variability [55], and responded to antidiabetic intervention [54]. In particular, our group has shown the involvement of oxidative stress in the early phases of type 1 diabetes, with an impaired balance between NO, serum uric acid (a potent antioxidant), and asymmetric-dimethyl-L-arginine (ADMA) [56]. As described above, ROS and RNS are able to directly modify the expression of adiponectin.…”

Section: Human Studiesmentioning

confidence: 94%

Oxidative Stress, Nitric Oxide, and Diabetes

Pitocco¹,

Zaccardi²,

Stasio³

et al. 2010

Rev Diabet Stud

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284

194

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■ AbstractIn the recent decades, oxidative stress has become focus of interest in most biomedical disciplines and many types of clinical research. Increasing evidence from research on several diseases show that oxidative stress is associated with the pathogenesis of diabetes, obesity, cancer, ageing, inflammation, neurodegenerative disorders, hypertension, apoptosis, cardiovascular diseases, and heart failure. Based on this research, the emerging concept is that oxidative stress is the "final common pathway", through which risk factors of several diseases exert their deleterious effects. Oxidative stress causes a complex dysregulation of cell metabolism and cell-cell homeostasis. In this review, we discuss the role of oxidative stress in the pathogenesis of insulin resistance and beta-cell dysfunction. These are the two most relevant mechanisms in the pathophysiology of type 2 diabetes, and in the pathogenesis of diabetic vascular complications, the leading cause of death in diabetic patients.

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“…reduced in adults with DM2 [9] and DM1 [10,11], as well as in youths with DM1 [12][13][14] when compared with healthy control subjects, and negatively related to glycemic control [9]. This suggests a complex and variable effect of chronic hyperglycemia on plasma levels of ADMA.…”

mentioning

confidence: 99%

Asymmetric dimethylarginine is negatively correlated with hyperglycemia in children

et al. 2015

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Role of asymmetric-dimethyl-l-arginine (ADMA) and nitrite/nitrate (NOx) in the pathogenesis of oxidative stress in female subjects with uncomplicated type 1 diabetes mellitus

Cited by 44 publications

References 21 publications

Diyabetik nöropatili hastalarında serum asimetrik dimetilarjinin ve nitrik oksit düzeyleri

Diyabetik nöropatili hastalarında serum asimetrik dimetilarjinin ve nitrik oksit düzeyleri

Oxidative Stress, Nitric Oxide, and Diabetes

Asymmetric dimethylarginine is negatively correlated with hyperglycemia in children

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