Role of ascorbic acid in reduction of the incidence of the atrial fibrillation in patients under B-blocker and undergoing coronary artery bypass graft operation in early post-operative period

Alshafey, Mohammed K.; Elrakhawy, Hany M.; Rezk, Moataz E.; Moustafa, Hani M.

doi:10.1016/j.jescts.2017.04.003

Cited by 11 publications

(13 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tanaka et al allocated patients to study groups by the month of admission [107] and Mirmohammadsadeghi allocated patients by their person numbers [121]. The method of allocation was not reported by Ebade et al [114] and by Alsfahey [118]. Most trials reported no or few drop-outs (Table S1).…”

Section: Resultsmentioning

confidence: 99%

“…Four trials did not report the methods in sufficient detail to enable conclusions to be drawn about the possibility of bias caused by poor blinding [106,107,114,118]. In our sensitivity analyses for vitamin C effect on ICU stay, we excluded the two particularly poorly reported trials [114,118], and a quasi-randomized trial [121].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, we checked the reference lists of the included trials, closely related papers and relevant reviews. We identified 18 publications in all [106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123] (Table 1; Table S1 of Supplementary file S1). One publication reported a 2 × 2 factorial trial on vitamin C and vitamin E [122].…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, to keep our analyses consistent with the MW p -values, for five studies [108,110,113,114,121], we calculated SE(log(RoM)) for length of ICU stay from the reported MW p -value (Supplementary file S2). For one study, we used the reported p -value, since that was more conservative than the p -value calculated from the published SD values for ICU stay [118] (see Table S1). For another study [111], we calculated SE(log(RoM)) for the duration of mechanical ventilation from the reported MW p -value.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

2019

View full text Add to dashboard Cite

A number of controlled trials have previously found that in some contexts, vitamin C can have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation, and acute kidney injury. However, the practical significance of these effects is not clear. The purpose of this meta-analysis was to evaluate whether vitamin C has an effect on the practical outcomes: length of stay in the intensive care unit (ICU) and duration of mechanical ventilation. We identified 18 relevant controlled trials with a total of 2004 patients, 13 of which investigated patients undergoing elective cardiac surgery. We carried out the meta-analysis using the inverse variance, fixed effect options, using the ratio of means scale. In 12 trials with 1766 patients, vitamin C reduced the length of ICU stay on average by 7.8% (95% CI: 4.2% to 11.2%; p = 0.00003). In six trials, orally administered vitamin C in doses of 1–3 g/day (weighted mean 2.0 g/day) reduced the length of ICU stay by 8.6% (p = 0.003). In three trials in which patients needed mechanical ventilation for over 24 hours, vitamin C shortened the duration of mechanical ventilation by 18.2% (95% CI 7.7% to 27%; p = 0.001). Given the insignificant cost of vitamin C, even an 8% reduction in ICU stay is worth exploring. The effects of vitamin C on ICU patients should be investigated in more detail.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

2019

View full text Add to dashboard Cite

show abstract

“…Vitamin C has been combined with other antioxidant substances to minimize oxidative damage, as well as with anti-arrhythmic drugs such as beta-blockers and diltiazem with the objective to reduce the incidence of postoperative cardiac arrhythmia. In combination with beta-blockers, the incidences of AF and ICU-LOS were significantly reduced compared to CABG-patients who only received betablocker pre-surgery [57].…”

Section: Vitamin C In Combination With Other Antioxidant Therapiesmentioning

confidence: 92%

Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients—Review and Pragmatic Approach

Hill¹,

Borosch²,

Benstöm³

et al. 2018

Preprint

View full text Add to dashboard Cite

The pleiotropic biochemical and antioxidant functions of Vitamin C (Vit C) have recently sparked interest in its application in intensive care. Vit C protects important organ systems such as the cardiovascular, neurologic and renal system during inflammation and oxidative stress. Vit C also influences the systems of coagulation and inflammation and its application might prevent the development of organ damage. The current evidence of Vit C’s effect on the pathophysiological reactions during various acute stress events, such as sepsis, shock, trauma, burn and ischemia-reperfusion injury imposes the question, if the application of Vit C might be especially beneficial for cardiac surgery patients, who are routinely exposed to ischemia/reperfusion and subsequent inflammation, systematically affecting different organ systems. This review covers current knowledge about the role of Vit C in cardiac surgery patients with focus on its influence on organ dysfunctions. The relationships between Vit C and clinical health outcomes are reviewed with special emphasis on its application in cardiac surgery. Additionally, this review pragmatically discusses evidence regarding the administration of Vitamin C in every day clinical practice, tackling the issues of safety, monitoring, dosage and most the appropriate application strategy.

show abstract

Preoperative and postoperative administration of vitamin C in cardiac surgery patients – settings, dosages, duration, and clinical outcomes: a narrative review

Athanasiou,

Charalambous,

Anastasiou

et al. 2024

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Vitamin C or ascorbic acid is a water-soluble vitamin capable of directly donating electrons to reactive oxygen species, attenuating electrical remodeling, and cardiac dysfunction in patients undergoing cardiac surgery (CS), considered one of the most effective defenses against free radicals in the blood, thus being one of the first antioxidants consumed during oxidative stress. The aim of this review is to assess the effects of perioperative administration of vitamin C in CS patients. A comprehensive literature search was conducted in order to identify prospective cohort studies and/or randomized controlled trials reporting on the perioperative effects of vitamin C among adult patients undergoing CS. Studies published between January 1980 to December 2022 were included in our search, resulting in a total of 31 articles that met all our inclusion criteria. There seems to be a beneficial effect of vitamin C supplementation in arrhythmias such as in postoperative atrial fibrillation, reduction of ICU length of stay, and hospital length of stay, reduction in postoperative ventilation time, in inotropic demand, and in postoperative fatigue. Vitamin C can act as a scavenger of free radicals to decrease the peroxidation of the lipids present in the cell membrane, and to protect the myocardium postoperatively from ischemia/reperfusion injury, thus attenuating oxidative stress and inflammation. It represents a readily available and cost-effective strategy that could improve the outcome of patients undergoing CS, by reducing the risk of serious cardiovascular adverse events, both perioperatively and postoperatively.

show abstract

Role of ascorbic acid in reduction of the incidence of the atrial fibrillation in patients under B-blocker and undergoing coronary artery bypass graft operation in early post-operative period

Cited by 11 publications

References 10 publications

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients—Review and Pragmatic Approach

Preoperative and postoperative administration of vitamin C in cardiac surgery patients – settings, dosages, duration, and clinical outcomes: a narrative review

Contact Info

Product

Resources

About

Role of ascorbic acid in reduction of the incidence of the atrial fibrillation in patients under B-blocker and undergoing coronary artery bypass graft operation in early post-operative period

Cited by 11 publications

References 10 publications

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients&mdash;Review and Pragmatic Approach

Preoperative and postoperative administration of vitamin C in cardiac surgery patients – settings, dosages, duration, and clinical outcomes: a narrative review

Contact Info

Product

Resources

About

Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients—Review and Pragmatic Approach