Role of Ascorbic Acid in Scavenging Free Radicals and Lead Toxicity from Biosystems

Tariq, Shabbir A.

doi:10.1007/s12033-007-0045-x

Cited by 29 publications

(22 citation statements)

References 26 publications

(21 reference statements)

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“…Both the enzymes are important against oxygen metabolism. [20] The first line of defense against superoxide free radicals is the enzyme known as “Superoxide dismutase” or (SOD), that is considered the most effective antioxidant. Depletion of SOD activity was observed during lead exposure.…”

Section: Discussionmentioning

confidence: 99%

The protective effect of Rubia cordifolia against lead nitrate-induced immune response impairment and kidney oxidative damage

2011

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Objectives:To evaluate the in vivo antioxidant activity of the ethanolic extract of the roots of Rubia cordifolia (RC) and to study its influence on lead nitrate-induced impairment of immune responses.Materials and Methods:Seventy-two adult male Swiss albino mice were used for biochemical and immunological studies and were divided into six groups of six mice each. Mice were treated with lead nitrate (40 mg/kg, orally) either alone and or in combination with RC (50 and 100 mg/kg body weight) daily for 40 days. For immunological studies, all mice were challenged twice with sheep RBC with on days 14 and 20 of the experiment. The immune function was assessed using macrophage yield, viability of macrophage, phagocytic index, serum immunoglobulin level, and plaque forming cell count (PFC), whereas the oxidative stress was assessed by estimating lipid peroxidation (LPO), reduced glutathione (GSH) content, and the activities of superoxide dismutase (SOD) and catalase (CAT).Results:Lead nitrate administration induced a significant (P<0.001) increase in LPO, whereas a significant (P<0.001) depletion of CAT and GSH in renal tissues. In addition, it also showed a significant (P<0.001) reduction in macrophage yield, viability of macrophage, phagocyte index, serum immunoglobulin level, and PFC in kidney. However, combination treatment with RC observed a significant (P<0.001) reversal of lead nitrate-induced toxicity on oxidative stress and immunological parameters.Conclusion:The lead nitrate-induced immunosuppression is due to oxidative stress and RC can prevent the same by virtue of its in vivo antioxidant property.

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Section: Discussionmentioning

confidence: 99%

The protective effect of Rubia cordifolia against lead nitrate-induced immune response impairment and kidney oxidative damage

2011

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“…Since in the present study no significant increase has been observed in serum/plasma levels of folate and PLP between quartiles of low and high daily juice consumption, it appears that decrease in homocysteine level because of increased fruit juice consumption could be due to a different mechanism. Studies have shown that high doses of vitamin C decrease levels of blood Pb probably through chelation [24], [25]. If a good proportion of blood Pb is bound to homocysteine, it is possible that its chelation by vitamin C present in fruit juice could enhance its excretion.…”

Section: Discussionmentioning

confidence: 99%

Association of Blood Lead (Pb) and Plasma Homocysteine: A Cross Sectional Survey in Karachi, Pakistan

Yakub

Iqbal

2010

PLoS ONE

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BackgroundHigh blood lead (Pb) and hyperhomocysteinemia have been found to be associated with cardiovascular disease (CVD). Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population. The objective of the present study was to assess the relationship of blood Pb to the risk of hyperhomocysteinemia in a low income urban population of Karachi, Pakistan.Methodology/Principal FindingsIn a cross sectional survey, 872 healthy adults (355 males, 517 females; age 18–60 years) were recruited from a low income urban population of Karachi. Fasting venous blood was obtained and assessed for blood Pb and plasma/serum homocysteine, folate, pyridoxal phosphate (PLP, a coenzymic form of vitamin B6) and vitamin B12. The study population had median (IQR) blood Pb of 10.82 µg/dL (8.29–13.60). Prevalence of high blood Pb (levels >10 µg/dL) was higher in males compared to females (62.5% males vs 56% females; p value = 0.05). Mean ± SD/median (IQR) value of plasma homocysteine was significantly higher in the highest quartile of blood Pb compared to the lowest quartile 16.13±11.2 µmol/L vs 13.28±9.7µmol/L/13.15 (10.33–17.81) µmol/L vs 11.09 (8.65 14.31) µmol/L (p value<0.001). Daily consumption of fruit juice had a positive influence on both levels of plasma homocysteine and blood Pb. Compared with the lowest quartile of blood Pb, the OR for hyperhomocysteinemia was 1.69 (95% CI, 1.00 to 2.85) for the fourth quartile when the model was adjusted for age, gender, folate and vitamin B12.Conclusions/SignificanceThis study showed a relationship between blood Pb and hyperhomocysteinemia in a general population of Karachi, Pakistan. The harmful effect of Pb on cardiovascular system could be due to its association with hyperhomocysteinemia.

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“…Its property of quenching ROS along with metal chelation makes it a potential detoxifying agent for lead (Das & Saha, 2010; Tariq, 2007). A recent study done by Chang et al (2011) showed the defensive effect of ascorbic acid on oxidative stress, developed in the hippocampus of lead exposed suckling rats.…”

Section: Vitaminsmentioning

confidence: 99%

Toxicity of lead: a review with recent updates

Flora¹,

Gupta²,

Tiwari³

2012

Interdisciplinary Toxicology

1,713

1,030

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Lead poisoning has been recognized as a major public health risk, particularly in developing countries. Though various occupational and public health measures have been undertaken in order to control lead exposure, cases of lead poisoning are still reported. Exposure to lead produces various deleterious effects on the hematopoietic, renal, reproductive and central nervous system, mainly through increased oxidative stress. These alterations play a prominent role in disease manifestations. Modulation of cellular thiols for protection against reactive oxygen species (ROS) has been used as a therapeutic strategy against lead poisoning. N-acetylcysteine, α-lipoic acid, vitamin E, quercetin and a few herbal extracts show prophylaxis against the majority of lead mediated injury in both in vitro and in vivo studies. This review provides a comprehensive account of recent updates describing health effects of lead exposure, relevant biomarkers and mechanisms involved in lead toxicity. It also updates the readers about recent advances in chelation therapy and newer therapeutic strategies, like nanoencapsulation, to treat lead induced toxic manifestations.

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Role of Ascorbic Acid in Scavenging Free Radicals and Lead Toxicity from Biosystems

Cited by 29 publications

References 26 publications

The protective effect of Rubia cordifolia against lead nitrate-induced immune response impairment and kidney oxidative damage

The protective effect of Rubia cordifolia against lead nitrate-induced immune response impairment and kidney oxidative damage

Association of Blood Lead (Pb) and Plasma Homocysteine: A Cross Sectional Survey in Karachi, Pakistan

Toxicity of lead: a review with recent updates

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