ROLE OF ASCORBIC ACID & STATIN IN REDUCTION OF THE INCIDENCE OF THE ATRIAL FIBRILLATION IN PATIENTS UNDER B-BLOCKER AND UNDERGOING CORONARY ARTERY BYPASS GRAFT OPERATION IN EARLY POST-OPERATIVE PERIOD

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia that is associated with significant morbidity and mortality. Current available treatments remain ineffective for symptom management and secondary prevention and are often associated with serious side effects. While electrophysiological remodelling has been identified as a significant initiating stage, the mechanisms underlying AF pathogenesis are poorly understood. Growing research recently has implicated oxidative stress and inflammation in AF pathogenesis. In order to support the use of antioxidant vitamins C and anti-inflammatory statin combined with Bblocker in the prevention of AF post CABG, we searched the literature for proof. Antioxidant vitamin C has shown a role in AF prevention post CABG through its reactive-oxygen-species-(ROS-) scavenging impact. Methodology: A prospective controlled randomized study will include (three hundred patients aged from 40 to 65 years of both sexes). They will be divided into three groups of patients: Group I: A hundred (CABG) patients commenced on only B-blocker for at least one week pre-operatively. Group II: A hundred (CABG) patients commenced on B-blocker & ascorbic acid for at least one week pre-operatively. Group III: A hundred (CABG) patients commenced on B-blocker& statin for at least one week pre-operatively. Results: 24 patients out of 100 patients in the 1st group experienced atrial fibrillation, compared with 6 out of 100 in the 2nd group, and 7 out of 100 patients in the 3rd group experienced atrial fibrillation. Conclution: combination of B-blocker with ascorbic acid & statin is better than B-blocker alone in reduction of atrial fibrillation after CABG in early post operative period.