Role of arterial stiffness in the association between hand grip strength and cardiovascular events: the Korean Genome and Epidemiology Study

Kim, Woo Hyeun; Kim, Seong Hwan; Choi, Cheol Ung; Lee, Seung ku; Kang, Dong Oh; Choi, Jah Yeon; Roh, Seung Young; Na, Jin Oh; Kim, Jin Won; Kim, Eung Ju; Rha, Seung Woon; Park, Chang Gyu; Seo, Hong Seog; Shin, Chol

doi:10.1097/hjh.0000000000002753

Cited by 8 publications

(8 citation statements)

References 38 publications

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“…However, other studies have shown that HGS in older adults is not associated with arterial stiffness (25). The results of the ANSAN cohort study in Korea showed that baPWV and CIMT were not correlated with HGS (36), which was partially consistent with our results. In addition, our study also confirmed that baPWV was negatively correlated with HGS, but CIMT was not correlated with HGS.…”

Section: Association Between Arterial Stiffness and Hgssupporting

confidence: 89%

“…When aging or disease occurs, atherosclerotic plaque deposition, vascular morphological changes, and CIMT changes, but vascular vasomotor function may not be affected at this time; moreover, vascular morphology is abnormal, but vasomotor function may be normal (38). Previous studies have shown that HGS is more closely related to central artery stiffness (36). This finding is consistent with our finding that baPWV is negatively Multiple-adjusted standardized logistic regression analysis of low HGS Low/normal HGS as the dependent variable, with numerical variables standardized for consistency.…”

Section: Association Between Arterial Stiffness and Hgsmentioning

confidence: 99%

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Arterial stiffness is associated with handgrip strength in relatively healthy Chinese older adults

He,

Niu,

et al. 2024

Front. Nutr.

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BackgroundIncreased arterial stiffness and low handgrip strength (HGS) are associated with poor health outcomes and are a severe health risk for older adults. However, there is limited evidence and mixed results on whether there is an association between them. Therefore, this study focused on the association between arterial stiffness and HGS in relatively healthy older adults in Beijing, China.MethodsIn 2016, 2,217 adult volunteers were recruited in Beijing. Brachial-ankle pulse wave velocity (baPWV) and the ankle-brachial index were measured using an automatic vascular profiling system. Carotid artery intima-media thickness and common carotid artery-internal diameter (CCAID) were evaluated using Doppler ultrasound, and HGS was measured with a dynamometer. Low HGS was determined using the Asian Sarcopenia Working Group 2019 criteria. Multivariate linear and logistic regressions evaluated the relationship between arterial stiffness and HGS.ResultsUltimately, 776 relatively healthy older adults (mean age 69.05 ± 6.46 years) were included. Based on the AWGS2019 criteria, 137 participants were defined as having low HGS. Compared to the normal HGS group, the low HGS group was older and had higher baPWV (p < 0.001) but lower CCAID, body mass index (BMI) and hemoglobin (Hb) (p < 0.05). The multiple linear regression analysis revealed that baPWV was negatively correlated with HGS (β = −0.173, t = −2.587, p = 0.01). Multivariate logistic regression analysis showed that baPWV and CCAID were associated with an increased risk of low HGS (odds ratio (OR) per SD increase: 1.318, p = 0.007; OR per SD increase: 0.541, p < 0.001).ConclusionArterial stiffness and HGS were significantly negatively correlated in relatively healthy Chinese older adults. Low HGS is associated with increased arterial stiffness. Encouraging exercise training to improve HGS, thereby reducing arterial stiffness and the risk of cardiovascular events, may be a simple and effective intervention.

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Section: Association Between Arterial Stiffness and Hgssupporting

confidence: 89%

Section: Association Between Arterial Stiffness and Hgsmentioning

confidence: 99%

Arterial stiffness is associated with handgrip strength in relatively healthy Chinese older adults

He,

Niu,

et al. 2024

Front. Nutr.

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“…A large population-based cross-sectional study in Switzerland showed an association between muscle strength and cardiovascular risk markers such as waist circumference (WC) and fat mass [ 9 ]. Moreover, muscle strength was associated with cardiovascular risk factors, including blood pressure [ 10 , 13 ], diabetes [ 10 , 11 , 16 ], lipid makers [ 10 , 13 ], and atherosclerosis [ 14 , 15 ]. Furthermore, besides cardiovascular risk factors, muscle strength is also associated with anemia [ 12 ] and pulmonary function [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study

Noji,

Hatanaka,

Nakaya

et al. 2024

BMC Public Health

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Background Upper and lower extremity muscle strength can be used to predict health outcomes. However, the difference between the relation of upper extremity muscle and of lower extremity muscle with physiological factors is unclear. This study aimed to evaluate the association between physiological data and muscle strength, measured using grip and leg extension strength, among Japanese adults. Methods We conducted a cross-sectional study of 2,861 men and 6,717 women aged ≥ 20 years living in Miyagi Prefecture, Japan. Grip strength was measured using a dynamometer. Leg extension strength was measured using a hydraulic isokinetic leg press machine. Anthropometry and physiological data, including blood pressure, calcaneal ultrasound bone status, pulmonary function, carotid echography, and blood information, were assessed. We used a general linear model adjusted for age, body composition, and smoking status to evaluate the association between muscle strength and physiological factors. Results Grip and leg extension strength were positively associated with bone area ratio, vital capacity, forced vital capacity, forced expiratory volume in one second, and estimated glomerular filtration rate, and negatively associated with waist circumference and percentage body fat mass in both the sexes. Diastolic blood pressure was positively associated with grip strength in both the sexes and leg extension strength in men, but not women. High-density lipoprotein cholesterol and red blood cell counts were positively associated with grip and leg extension strength in women, but not men. In both the sexes, pulse rate, total cholesterol, and uric acid were consistently associated with only leg extension strength, but not grip strength. In women, glycated hemoglobin demonstrated negative and positive associations with grip and leg extension strength, respectively. Conclusions Grip and leg extension strength demonstrated similar associations with anthropometry, pulmonary function, and estimated glomerular filtration rate, but the associations with the other factors were not always consistent.

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“…A growing body of evidence manifests that vascular aging can aggravate the risk of CVD (10). Epidemiological studies have shown that arterial hardness has a higher predictive value than traditional cardiovascular risk factors in determining cardiovascular risk and has become an important predictor of end-organ damage and overall risk of CVD (11)(12)(13)(14). The inducement and molecular mechanism of arterial stiffness are very complex and unsolved.…”

Section: Introductionmentioning

confidence: 99%

Association Between Plasma Fibulin-1 and Brachial-Ankle Pulse Wave Velocity in Arterial Stiffness

Luo

Yan

Liang

et al. 2022

Front. Cardiovasc. Med.

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Arterial stiffness forms the basis of cardiovascular diseases (CVD) and is also an independent predictor of CVD risk. Early detection and intervention of arterial stiffness are important for improving the global burden of CVD. Pulse wave velocity (PWV) is the gold standard for assessing arterial stiffness and the molecular mechanism of arterial stiffness remains to be studied. Extracellular matrix (ECM) remodeling is one of the major mechanisms of arterial stiffness. Partial quantitative changes of ECM proteins can be detected in plasma. Therefore, we examined the hypothesis that a discovery proteomic comparison of plasma proteins between high arterial stiffness (baPWV ≥ 1,400 cm/s) and normal arterial stiffness (baPWV < 1,400 cm/s) populations might identify relevant changed ECM proteins for arterial stiffness. Plasma samples were randomly selected from normal arterial stiffness (n = 6) and high arterial stiffness (n = 6) people. Isobaric tags for relative and absolute quantitation (iTRAQ) based quantitative proteomics technique was performed to find a total of 169 differentially expressed proteins (DEPs). Nine ECM proteins were included in all DEPs and were all up-regulated proteins. Fibulin-1 had the highest statistically fold-change (FC = 3.7, p < 0.0001) in the high arterial stiffness population compared with the control group during the nine ECM proteins. The expression of plasma fibulin-1 in normal arterial stiffness (n = 112) and high arterial stiffness (n = 72) populations was confirmed through enzyme-linked immunosorbent assay (ELISA). Similarly, ELISA results showed that plasma concentrations of fibulin-1 in the high arterial stiffness group were higher than those in the normal arterial stiffness group (12.69 ± 0.89 vs. 9.84 ± 0.71 μg/ml, p < 0.05). Univariate analysis of fibulin-1 with brachial-ankle pulse wave velocity (baPWV) indicated that fibulin-1 was positively correlated with baPWV in all participants (r = 0.32, p < 0.01) and a stronger positive correlation between baPWV and fibulin-1 in high arterial stiffness group (r = 0.64, p < 0.0001) was found. Multiple regression analysis of factors affecting baPWV showed that fibulin-1 was also a significant determinant of the increased ba-PWV (R2 = 0.635, p = 0.001). Partial correlation analysis showed that baPWV increased with the growth of plasma fibulin-1(r = 0.267, p < 0.001). In conclusion, our results demonstrated that fibulin-1 is positively correlated with ba-PWV and an independent risk factor for arterial stiffness.

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Role of arterial stiffness in the association between hand grip strength and cardiovascular events: the Korean Genome and Epidemiology Study

Cited by 8 publications

References 38 publications

Arterial stiffness is associated with handgrip strength in relatively healthy Chinese older adults

Arterial stiffness is associated with handgrip strength in relatively healthy Chinese older adults

Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study

Association Between Plasma Fibulin-1 and Brachial-Ankle Pulse Wave Velocity in Arterial Stiffness

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