Role of Aromatase Inhibitor in Endometriosis

Yoong, Cheau Ying; De, Somsubhra

doi:10.18488/journal.2.2018.82.73.85

Cited by 2 publications

(2 citation statements)

References 69 publications

(75 reference statements)

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“…Endometriosis (endometriosis) refers to the development and infiltration of endometrial tissue outside the endometrium. A common gynecological disease in women that occurs when functional endometrial cells is implanted outside the endometrium [ 24 ]. If repeated bleeding will cause lumps and nodules, it may cause pain and can invade any part of the body, such as bladder, kidney, ureter, lung, and pleura.…”

Section: Comparison Of Endometriosis and Normal Endometriummentioning

confidence: 99%

A Comparative Study of Endometriosis and Normal Endometrium Based on Ultrasound Observation

Lin

Wang

Zhu

2022

Applied Bionics and Biomechanics

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In order to compare the microscopic ultrastructure of eutopic endometrium and normal endometrium in patients with endometriosis, to study the specific pathogenesis of endometriosis. In this paper, on the basis of using B-ultrasound technology, several patients with endometriosis were subjected to B-ultrasound to observe the ultrastructure of the eutopic uterine endometrium and compared with the pictures of normal endometrium to carry out the specific analysis between the two ultrastructural comparisons. This study is based on the analysis of B-ultrasound images of patients with endometriosis, compares the difference between their ultrastructure and normal human body, and conducts specific pathological diagnosis and analysis to find out the impact of the endometrium in place. The specific factors of the occurrence of lesions and the corresponding treatment methods are proposed. The experimental results show that the ultrastructure of endometriosis eutopic endometrium is different from that of normal endometrium. The microvilli of secretory cells and the cilia of ciliated cells of the former are abnormally increased and lengthened, and they are superior to B-ultrasound technology. The success rate of the examination is 93.75%, which can play an important role in the specific examination process of patients with endometriosis, as one of the actual indicators of detection. Under the electron microscope, microvilli are tiny finger-like protrusions extending from the cell membrane and the cytoplasm on the free surface of the cell, surrounded by the cell membrane and perpendicular to the cell membrane surface.

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Section: Comparison Of Endometriosis and Normal Endometriummentioning

confidence: 99%

A Comparative Study of Endometriosis and Normal Endometrium Based on Ultrasound Observation

Lin

Wang

Zhu

2022

Applied Bionics and Biomechanics

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“…12). 28,29 Administration of aromatase inhibitors (AI) in endometriosis can reduce aromatase activity in endometrial tissue directly, reduce estrogen levels which then suppress COX-2 activity, and reduce PGE2 levels, which in turn reduces levels of PGE2 and ultimately break the whole positive feedback loop. 30,31 Administration to premenopausal women will suppress estrogen production and increase FSH production by the pituitary gland, and 1-5 mg of letrozole will decrease estrogen levels by 97-99%.…”

Section: Epigenetics Therapy In Endometriosismentioning

confidence: 99%

The Role of Epigenetics in Endometriosis

Widhusadi¹,

Anantasika²

2023

Journal of South Asian Federation of Obstetrics and Gynaecology

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Epigenetics is a field that studies that study the changing in the regulation of gene activity and expression that are independent of the DNA sequence of genes and can be inherited or inherited. This refers to a change in phenotypic status that is not based on a change in genotype. Epigenetics is known to have a part in the pathogenesis of endometriosis. Epigenetics can cause endometriosis is known through mechanisms such as DNA methylation, histone modification, and microRNA (miRNA). These various mechanisms are also related to environmental, immune, and hormonal factors that trigger endometriosis. Endometriosis is a gynecological problem involving the stroma of the endometrium and glands which normally line the uterine cavity but is found outside the uterine cavity (endometrial-like tissues). Until now, the etiopathogenesis of endometriosis is still under debate. Etiopathogenesis of endometriosis is said to be related to the genetic system and epigenetic abnormalities. Reversibility is the key to epigenetic change therefore it is used as a potential epigenetic therapy option. Enzymes that control epigenetic change are the goal of studies into pharmacological interventions in endometriosis. Therefore, the role of epigenetics requires further attention in the diagnosing, management, and prognosis of endometriosis condition so that the patient's quality of life will be better.

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Role of Aromatase Inhibitor in Endometriosis

Abstract: Article History

Cited by 2 publications

References 69 publications

A Comparative Study of Endometriosis and Normal Endometrium Based on Ultrasound Observation

A Comparative Study of Endometriosis and Normal Endometrium Based on Ultrasound Observation

The Role of Epigenetics in Endometriosis

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