Role of arginine in superficial wound healing in man

Debats, I.B.J.G.; Wolfs, Tim G. A. M.; Gotoh, Tomomi; Cleutjens, Jack P.M.; Peutz‐Kootstra, Carine J.; Hulst, René R W J van der

doi:10.1016/j.niox.2009.07.006

Cited by 99 publications

(76 citation statements)

References 69 publications

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“…All primary outcome measures i.e., wound healing progress, patients' compliance with and patients' rate of the specific ONS were generally positive. These findings are in line with clinical studies showing a positive effect of nutritional supplementation with additional protein, arginine and micronutrients to promote PU healing [17,18,[22][23][24][25][26][27][28][29][30]. In contrast, the findings of two studies were not in line with the findings of these studies [31,32].…”

Section: Discussionsupporting

confidence: 64%

Effects of an Arginine-Enriched Oral Nutritional Supplement on the Healing of Chronic Wounds in Non-Malnourished Patients; A Multicenter Case Series from the Netherlands and Hungary

Neyens¹,

Cereda²,

Rozsos³

et al. 2017

J Gerontol Geriatr Res

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Section: Discussionsupporting

confidence: 64%

Effects of an Arginine-Enriched Oral Nutritional Supplement on the Healing of Chronic Wounds in Non-Malnourished Patients; A Multicenter Case Series from the Netherlands and Hungary

Neyens¹,

Cereda²,

Rozsos³

et al. 2017

J Gerontol Geriatr Res

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“…27,28 Contrasting the macrophage-restricted expression of arginase I in rodent wounds, 17 arginase has been found in neutrophils in acute human wounds and in fibroblasts in chronic wounds and ulcers but not in macrophages. 29,30 Arginase I is also expressed in human, but not in rodent, erythrocytes, 31 and lysed red blood cells contribute arginase to human wounds. Arginase activity is highest in postmastectomy wound fluids within 24 hours of surgery and correlates with the hemoglobin concentration in the fluids (unpublished observations).…”

Section: Wound Macrophages and The Alternatively Activated Phenotypementioning

confidence: 99%

Wound Macrophages as Key Regulators of Repair

Brancato

Albina

2011

The American Journal of Pathology

460

389

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Recent results call for the reexamination of the phenotype of wound macrophages and their role in tissue repair. These results include the characterization of distinct circulating monocyte populations with temporally restricted capacities to migrate into wounds and the observation that the phenotype of macrophages isolated from murine wounds partially reflects those of their precursor monocytes, changes with time, and does not conform to current macrophage classifications. Moreover, findings in genetically modified mice lacking macrophages have confirmed that these cells are essential to normal wound healing because their depletion results in retarded and abnormal repair. This mini-review focuses on current knowledge of the phenotype of wound macrophages, their origin and fate, and the specific macrophage functions that underlie their reparative role in injured tissues, including the regulation of the cellular infiltration of the wound and the production of transforming growth factor-␤ and vascular endothelial growth factor. The resolution of injury through replacement by scar has been preserved in evolution and applies to virtually all soft tissues in mammals. A healed wound is the result of the activities of cells that constitute what can be conceptually described as a wound organ. This transient neoorgan is assembled at the time and site of injury and disassembled once repair is complete, leaving in place a scar as evidence of the repair process. The parenchyma of the wound organ is composed of a temporally changing assembly of inflammatory cells, neovessels, fibroblasts and myofibroblasts, regenerating nerves, and other cells specific to the site of the injury (eg, keratinocytes, osteocytes, and hepatocytes).Two recent developments led to this review of wound macrophages. First, studies in both humans and rodents have demonstrated the existence of diverse subpopulations of circulating monocytes with, at least in mice, distinct and time-restricted abilities to migrate into wounds and other sites of tissue injury (Figure 1). These immediate precursors of wound macrophages are required for repair by scarring in organs as diverse as skin, heart, liver, and kidney. Second, the concept that macrophages involved in tissue repair express the alternatively activated phenotype first proposed by Gordon 1 has been retained in the literature.2 Results from studies of macrophages isolated from wounds, however, contest this paradigm by demonstrating that they are not alternatively activated. Wound macrophages exhibit phenotypes that partially reflect those of their monocyte precursors, change with time, and fail to be adequately described by macrophage classifications based on activation profiles or functional capacity (Figure 2). 3This review addresses the origin and fate of wound macrophages, their regulatory interactions with other cellular populations in the wound, and the roles of macrophagederived transforming growth factor-␤ (TGF-␤) and vascular endothelial growth factor (VEGF) in the regulation of wound fibrosis an...

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“…65,66 Arginine is also a precursor for nitric oxide, an essential compound for proper wound healing. [67][68][69] Arginine, as well as ornithine, stimulates T-cells and the production of growth hormone, which may also aid the healing wound. [64][65][66] In the 1970s Seifter et al observed that growing animals required more arginine than mature animals and demonstrated that injured rats healed better with arginine supplementation based on measurements of wound-breaking strength.…”

Section: Arginine and Glutamine In Wound Healingmentioning

confidence: 99%

Nutrition and Chronic Wounds

Molnár

Underdown

Clark

2014

Advances in Wound Care

110

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Nutrition is one of the most basic of medical issues and is often ignored as a problem in the management of our chronic wound patients. Unfortunately, malnutrition is widespread in our geriatric patients even in nursing homes in developed countries. Attention to basic nutrition and providing appropriate supplements may assist in the healing of our chronic wounds. Recent research has revealed the epidemiology of malnutrition in developed countries, the similarities to malnutrition in developing countries, and some of the physiologic and sociologic causes for this problem. More information is now available on the biochemical effects of nutrient deficiency and supplementation with macronutrients and micronutrients. In some cases, administration of isolated nutrients beyond recommended amounts for healthy individuals may have a pharmacologic effect to help wounds heal. Much of the knowledge of the nutritional support of chronic wounds is based on information that has been obtained from trauma management. Due to the demographic differences of the patients and differences in the physiology of acute and chronic wounds, it is not logical to assume that all aspects of nutritional support are identical in these patient groups. Before providing specific nutritional supplements, appropriate assessments of patient general nutritional status and the reasons for malnutrition must be obtained or specific nutrient supplementation will not be utilized. Future research must concentrate on the biochemical and physiologic differences of the acute and chronic wounds and the interaction with specific supplements, such as antioxidants, vitamin A, and vitamin D.

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Role of arginine in superficial wound healing in man

Cited by 99 publications

References 69 publications

Effects of an Arginine-Enriched Oral Nutritional Supplement on the Healing of Chronic Wounds in Non-Malnourished Patients; A Multicenter Case Series from the Netherlands and Hungary

Effects of an Arginine-Enriched Oral Nutritional Supplement on the Healing of Chronic Wounds in Non-Malnourished Patients; A Multicenter Case Series from the Netherlands and Hungary

Wound Macrophages as Key Regulators of Repair

Nutrition and Chronic Wounds

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