Role of arachidonic acid lipoxygenase pathway in Asthma

Luo, Yacan; Jin, Minli; Lou, Lejing; Song, Yang; Li, Chengye; Li, Xi; Zhou, Meixi; Cai, Chang

doi:10.1016/j.prostaglandins.2021.106609

Cited by 12 publications

(10 citation statements)

References 87 publications

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“…In the present study, 20:4n-6, which regulates immune responses in hypersensitivity reactions and serves as a precursor for eicosanoids 45 , increased in the SUP samples of pooled EA horses. Eicosanoids from 20:4n-6, such as prostaglandin E 2 (PGE 2 ) and cysteinyl leukotrienes, are bioactive lipid mediators primarily associated with inflammatory conditions and pain 46 .…”

Section: Discussionsupporting

confidence: 51%

Fatty acid fingerprints in bronchoalveolar lavage fluid and its extracellular vesicles reflect equine asthma severity

Höglund

Nieminen

Mustonen

et al. 2023

Sci Rep

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Equine asthma (EA) is an inflammatory disease of the lower airways driven by mediators released from cells. Extracellular vesicles (EVs) are vehicles for lipid mediators, which possess either pro-inflammatory or dual anti-inflammatory and pro-resolving functions. In this study, we investigated how the respiratory fatty acid (FA) profile reflects airway inflammatory status. The FA composition of bronchoalveolar lavage fluid (BALF), BALF supernatant, and bronchoalveolar EVs of healthy horses (n = 15) and horses with mild/moderate EA (n = 10) or severe EA (SEA, n = 5) was determined with gas chromatography and mass spectrometry. The FA profiles distinguished samples with different diagnoses in all sample types, yet they were insufficient to predict the health status of uncategorized samples. Different individual FAs were responsible for the discrimination of the diagnoses in different sample types. Particularly, in the EVs of SEA horses the proportions of palmitic acid (16:0) decreased and those of eicosapentaenoic acid (20:5n-3) increased, and all sample types of asthmatic horses had elevated dihomo-γ-linolenic acid (20:3n-6) proportions. The results suggest simultaneous pro-inflammatory and resolving actions of FAs and a potential role for EVs as vehicles for lipid mediators in asthma pathogenesis. EV lipid manifestations of EA can offer translational targets to study asthma pathophysiology and treatment options.

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Section: Discussionsupporting

confidence: 51%

Fatty acid fingerprints in bronchoalveolar lavage fluid and its extracellular vesicles reflect equine asthma severity

Höglund

Nieminen

Mustonen

et al. 2023

Sci Rep

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“…Previous studies have reported that eicosatetraenoic acid can act as a dual inhibitor of cyclooxygenase (COX1 and COX2) and lipoxygenase to block the production of leukotriene B4 (LTB4), which were important genes involved in inflammation [27]. Eicosatetraenoic acid can also compete with eicosatetraenoic acid in the arachnoidal-CoA synthetase step, and then prevent the uptake of eicosatetraenoic acid that plays a key role in immunological response and inflammation disease [28,29]. Eicosatetraenoic acid can stimulate the secretion of anti-inflammatory cytokines including IL-10 from macrophages in vitro [30].…”

Section: Discussionmentioning

confidence: 99%

Association between Polyunsaturated Fatty Acid Intake and Eczema in Children and Adolescents

Zhang¹,

Li²,

Fu³

2023

Int Arch Allergy Immunol

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Introduction: Eczema is a common allergic skin condition among children and adolescents, and polyunsaturated fatty acids (PUFAs) are a kind of fatty acid which were reported to be associated with reduced risk of eczema. Previous studies explored different types of PUFAs with various age groups of children and adolescents, and the influence of confounding factors such as medicine use was not considered. In the present study, we aimed to identify the associations between PUFAs and the risk of eczema in children and adolescents. These findings of our study might help better understand the associations between PUFAs and eczema. Methods: This cross-sectional study collected the data of 2,560 children and adolescents aged 6–19 years from National Health and Nutrition Examination Surveys (NHANES) between 2005 and 2006. Total PUFA, omega-3 (n-3), including octadecatrienoic acid/18:3, octadecatrienoic acid/18:4, eicosapentaenoic acid/20:5, docosapentaenoic acid/22:5, and docosahexaenoic acid/22:6, omega-6 (n-6), including octadecatrienoic acid/18:2 and eicosatetraenoic acid/20:4, total n-3 intake, total n-6 intake, and n-3/n-6 were main variables in this study. Univariate logistic regression was applied for identifying potential confounders for eczema. Univariate and multivariate logistic regression analysis were conducted to explore the associations between PUFAs and eczema. Subgroup analysis was performed on subjects with different ages, and patients complicated with other allergic diseases, allergy, and medicine use or not. Results: In total, there were 252 (9.8%) subjects who had eczema. After adjusting for confounding factors including age, race, poverty to income ratio (PIR), medicine use, hay fever, sinus infection, body mass index (BMI), serum total immunoglobulin E (IgE) antibody, and IgE, we observed that eicosatetraenoic acid/20:4 (OR = 0.17, 95% CI: 0.04–0.68) and total n-3 (OR = 0.88, 95% CI: 0.77–0.99) were linked with decreased risk of eczema in children and adolescents. Eicosatetraenoic acid/20:4 was correlated with decreased risk of eczema in participants without hay fever (OR = 0.82, 95% CI: 0.70–0.97) and medicine use (OR = 0.80, 95% CI: 0.68–0.94) or with allergy (OR = 0.75, 95% CI: 0.59–0.94). Total n-3 intake was associated with a reduced risk of eczema with the adjusted OR of 0.84, 95% CI: 0.72–0.98) in participants without hay fever. In those without sinus infection, octadecatrienoic acid/18:4 was linked with decreased risk of eczema (OR = 0.83, 95% CI: 0.69–0.99). Conclusion: N-3 and eicosatetraenoic acid/20:4 might be associated with the risk of eczema in children and adolescents.

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“…β-agonists have been shown to display different degrees of inhibition of IgE-mediated MC responses, depending on their potency and efficacy, but the high degree of tolerance to these compounds known to occur in smooth muscle cells develops even more rapidly in masts cells [129]. As previously elucidated, corticosteroids act at the transcriptional level, suppressing numerous stages of the inflammatory response and ultimately resulting in the inhibition of pro-inflammatory pathways in immune cells, including MCs [130].…”

Section: Non-atopic Asthmamentioning

confidence: 99%

Mast Cells in Upper and Lower Airway Diseases: Sentinels in the Front Line

Costanzo

Moro

et al. 2023

IJMS

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Mast cells (MCs) are fascinating cells of the innate immune system involved not only in allergic reaction but also in tissue homeostasis, response to infection, wound healing, protection against kidney injury, the effects of pollution and, in some circumstances, cancer. Indeed, exploring their role in respiratory allergic diseases would give us, perhaps, novel therapy targets. Based on this, there is currently a great demand for therapeutic regimens to enfeeble the damaging impact of MCs in these pathological conditions. Several strategies can accomplish this at different levels in response to MC activation, including targeting individual mediators released by MCs, blockade of receptors for MC-released compounds, inhibition of MC activation, limiting mast cell growth, or inducing mast cell apoptosis. The current work focuses on and summarizes the mast cells’ role in pathogenesis and as a personalized treatment target in allergic rhinitis and asthma; even these supposed treatments are still at the preclinical stage.

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Role of arachidonic acid lipoxygenase pathway in Asthma

Cited by 12 publications

References 87 publications

Fatty acid fingerprints in bronchoalveolar lavage fluid and its extracellular vesicles reflect equine asthma severity

Fatty acid fingerprints in bronchoalveolar lavage fluid and its extracellular vesicles reflect equine asthma severity

Association between Polyunsaturated Fatty Acid Intake and Eczema in Children and Adolescents

Mast Cells in Upper and Lower Airway Diseases: Sentinels in the Front Line

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