Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death

Venkatadri, Raj; Muni, T; Iyer, Anand Krishnan V.; Yakisich, Juan Sebastián; Azad, Neelam

doi:10.1038/cddis.2016.6

Cited by 204 publications

(161 citation statements)

References 58 publications

Supporting

Mentioning

149

Contrasting

Order By: Relevance

“…Interestingly, emerging studies have demonstrated that some herbal product (e.g curcumin, camptothecin, andrographolide and resveratrol etc.) can perform their anti-tumor effects through affecting miRNAs expression [16, 23-25]. However, whether the antitumor effect of baicalein is related to its modulation of miRNA expression in HCC is still unknown.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study found that andrographolide could altered miRNA expression profile and its downstream signals in hepatoma tumor tissues from mice [24]. Additionally, another recent study showed that resveratrol could regulate apoptotic and cell cycle machinery in breast cancer cells by modulating key tumor-suppressive miRNAs including miR-125b-5p, miR-200c-3p, miR-409-3p, miR-122-5p and miR-542-3p [25]. However, there is still no related report about the effects of baicalein on miRNA expression profile when it exerts its inhibition on hepatoma tumor growth.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Baicalein, a Natural Anti-Cancer Compound, Alters MicroRNA Expression Profiles in Bel-7402 Human Hepatocellular Carcinoma Cells

Bie

Sun

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Baicalein has been shown to possess significant anti-hepatoma activity by inhibiting cell proliferation. Whether the anti-proliferative effect of baicalein is related to its modulation of miRNA expression in hepatocellular carcinoma (HCC) is still unknown. Methods: The anti-proliferative effects of baicalein on HCC cell line Bel-7402 was assessed by detecting the proliferation activity, cell cycle distribution, expression changes of p21/CDKN1A, P27/CDKN1B, total Akt and phosphoryted AKT. Microarray analysis was conducted to determine the miRNA expression profiles in baicalein-treated or untreated Bel-7402 cells and then validated by qRT-PCR in two HCC cell lines (Bel-7402 and Hep3B). The gain-of-function of miR-3127-5p was performed by detecting anti-proliferative effects after transfecting miRNA mimics in cells. Finally, the expression level of miR-3127-5p in different HCC cell lines was determined by qRT-PCR. Results: Baicalein was able to inhibit the proliferation of Bel-7402 cells by inducing cell cycle arrest at the S and G2/M phase via up-regulating the expression of p21/CDKN1A and P27/CDKN1B and suppressing the PI3K/Akt pathway. Baicalein could alter the miRNA expression profiles in Bel-7402 cells. Putative target genes for differentially expressed miRNAs could be enriched in terms of cell proliferation regulation, cell cycle arrest and were mainly involved in MAPK, PI3K-Akt, Wnt, Hippo and mTOR signaling pathways. MiR- 3127-5p, one of up-regulated miRNAs, exhibits low expression level in several HCC cell lines and its overexpression could inhibit cell growth of Bel-7402 and Hep3B cell lines by inducing S phase arrest by up-regulating the expression of p21and P27 and repressing the PI3K/Akt pathway. Conclusions: Modulation of miRNA expression may be an important mechanism underlying the anti-hepatoma effects of baicalein.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Baicalein, a Natural Anti-Cancer Compound, Alters MicroRNA Expression Profiles in Bel-7402 Human Hepatocellular Carcinoma Cells

Bie

Sun

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Because of its pleiotropic activity, resveratrol is able to suppress or to interfere with these key inflammatory molecular targets almost instantly [61]. In addition, recent interest in resveratrol has focused on its ability for modulation of tumor-suppressive miRNA by inducing apoptotic cell death [62,63]. In absence of a clear mechanistic link, the activity of resveratrol may be partially dependent upon an impaired expression of certain miRNAs associated with inflammatory and tumor suppression effects (miR-663), proinflammatory effects (miR-155), or oncogenicity (miR -21).…”

Section: Molecular Targets Of Resveratrolmentioning

confidence: 99%

Anticancer Activities of Resveratrol in Colorectal Cancer

Schaafsma¹,

Hsieh²,

Doonan³

et al. 2016

Biol Med (Aligarh)

View full text Add to dashboard Cite

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a dietary polyphenolic phytochemical that has demonstrated health benefits such as cardioprotection, the prevention of neurodegeneration and chemoprevention. Resveratrol has shown great potential in the prevention and treatment of carcinomas and clinical trials support resveratrol as anticancer compound in colorectal carcinoma. Colorectal cancer remains a major cause of cancer-related deaths for both men and women in industrialized countries. Because of this widespread prevalence, identifying major risk factors and initiating colorectal screening procedures provide the distinct advantage for recognizing early disease and addressing treatable forms of CRC. Epidemiological studies of fruit and vegetable consumption in relationship to developing CRC have led to the notion that safe and inexpensive chemopreventive agents might be a valuable tool in diminishing the morbidity and mortality of CRC. While clinical trials and in vivo data show positive effects of resveratrol in CRC, the mechanism of action is relatively unclear. In this review, we will evaluate the current literature on the actions of resveratrol in CRC and provide a more mechanistic view of resveratrol in relationship with CRC.

show abstract

“…[8][9][10] Res also has neuroprotective effects and improves the pathological and behavioral outcomes of various types of nerve injury, including stroke, 11 traumatic brain injury, 12 spinal cord injury, 13 and peripheral nerve injury. 14 A number of mechanisms have been proposed to explain Res-induced neuroprotection, many of which invoke its anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol enhances IL-4 receptor-mediated anti-inflammatory effects in spinal cord and attenuates neuropathic pain following sciatic nerve injury

Cheng

Ding

et al. 2018

Mol Pain

View full text Add to dashboard Cite

Resveratrol has been showed to relieve neuropathic pain through its anti-inflammatory effects on the peripheral nerve system. However, it is not clear whether resveratrol, especially when administered systemically, is effective in alleviating the peripheral neuropathy-induced imbalance between pro-and anti-inflammatory responses in the central nervous system. To test this, we used a rat neuropathic pain model resulting from chronic constriction injury of the sciatic nerve. Resveratrol (200 mg/kg) or vehicle (dimethylsulfoxide) were administered intraperitoneally once daily for 14 consecutive days after chronic constriction injury. We found that resveratrol attenuated mechanical allodynia and thermal hyperalgesia in rats with chronic constriction injury. After 14 days of resveratrol treatment, expression of several anti-inflammatory cytokine receptors, including IL-1RA and IL-1R2, was increased in the dorsal spinal cord of rats with chronic constriction injury, and IL-4Ra was increased in dorsal spinal cord neurons. Knockdown of IL-4Ra in a neuronal cell line reversed the resveratrol-induced upregulation of IL-1RA and IL-1R2. These results indicate that resveratrol enhances IL-4 receptor-mediated anti-inflammatory responses in the spinal cord and thus might contribute to the alleviation of central sensitization following peripheral nerve injury.

show abstract

Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death

Cited by 204 publications

References 58 publications

Baicalein, a Natural Anti-Cancer Compound, Alters MicroRNA Expression Profiles in Bel-7402 Human Hepatocellular Carcinoma Cells

Baicalein, a Natural Anti-Cancer Compound, Alters MicroRNA Expression Profiles in Bel-7402 Human Hepatocellular Carcinoma Cells

Anticancer Activities of Resveratrol in Colorectal Cancer

Resveratrol enhances IL-4 receptor-mediated anti-inflammatory effects in spinal cord and attenuates neuropathic pain following sciatic nerve injury

Contact Info

Product

Resources

About