Role of apamin-sensitive small conductance calcium-activated potassium currents in long-term cardiac memory in rabbits

Yin, Dechun; Mu, Chunlai; Yang, Na; Wu, Adonis Z.; Xu, DongZhu; Tsai, Wei Chung; Yuan, Yuan; Tian, Zhipeng; Chan, Yi‐Hsin; Shen, Changyu; Chen, Zhenhui; Lin, Shien Fong; Weiss, James N.; Chen, Peng Sheng; Everett, Thomas H.

doi:10.1016/j.hrthm.2018.01.016

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…20 In addition, we recently demonstrated that inhibiting I KAS in a cardiac memory model increased the vulnerability to ventricular arrhythmias. 21 The data presented in this study suggests that the underlying mechanism of the QTc prolongation is through inhibiting I KAS . These studies support that when I KAS is inhibited within substrates in which I KAS is upregulated to maintain the repolarization reserve, the risk for initiation of ventricular arrhythmias is increased.…”

Section: Kas and Drug Safetymentioning

confidence: 60%

Effects of ondansetron on apamin-sensitive small conductance calcium-activated potassium currents in pacing-induced failing rabbit hearts

et al. 2020

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Section: Kas and Drug Safetymentioning

confidence: 60%

Effects of ondansetron on apamin-sensitive small conductance calcium-activated potassium currents in pacing-induced failing rabbit hearts

et al. 2020

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“…Optical signals were gathered at 2 ms/frame temporal resolution, acquired from 128 × 128 sites simultaneously over a 30 × 30 mm 2 area in each aspect of those hearts. For each optical recording, data were acquired continuously for 2 s. Optical signals were processed with both spatial (3 × 3 pixels Gaussian filter) and temporal (3 frames moving average) filtering ( 7 , 8 ).…”

Section: Methodsmentioning

confidence: 99%

Proinflammatory Cytokine Modulates Intracellular Calcium Handling and Enhances Ventricular Arrhythmia Susceptibility

Tsai

Hsiao

Lin

et al. 2021

Front. Cardiovasc. Med.

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Background: The mechanism of Interleukin-17 (IL-17) induced ventricular arrhythmia (VA) remains unclear. This study aimed to investigate the effect of intracellular calcium (Cai) handling and VA susceptibility by IL-17.Methods: The electrophysiological properties of isolated perfused rabbit hearts under IL-17 (20 ng/ml, N = 6) and the IL-17 with neutralizer (0.4 μg/ml, N = 6) were evaluated using an optical mapping system. The action potential duration (APD) and Cai transient duration (CaiTD) were examined, and semiquantitative reverse transcriptase-polymerase chain reaction analysis of ion channels was performed.Results: There were longer APD80, CaiTD80 and increased thresholds of APD and CaiTD alternans, the maximum slope of APD restitution and induction of VA threshold in IL-17 group compared with those in IL-17 neutralizer and baseline groups. During ventricular fibrillation, the number of phase singularities and dominant frequency were both significantly greater in IL-17 group than in baseline group. The mRNA expressions of the Na+/Ca2+ exchanger, phospholamban, and ryanodine receptor Ca2+ release channel were upregulated, and the subunit of L-type Ca2+ current and sarcoplasmic reticulum Ca2+-ATPase 2a were significantly reduced in IL-17 group compared to baseline and IL-17 neutralizer group.Conclusions: IL-17 enhanced CaiTD and APD alternans through disturbances in calcium handling, which may increase VA susceptibility.

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“…Studies have also been developed on rabbits. This is the case of a recent work that investigated the role of apamin on small conductance calcium-activated potassium current and found that it induced more action potential duration in long term cardiac memory, showing up-regulation of those sites [165]. Other models less common have also been searched.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

2020

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Bee venom (BV) is usually associated with pain since, when humans are stung by bees, local inflammation and even an allergic reaction can be produced. BV has been traditionally used in ancient medicine and in acupuncture. It consists of a mixture of substances, principally of proteins and peptides, including enzymes as well as other types of molecules in a very low concentration. Melittin and phospholipase A2 (PLA2) are the most abundant and studied compounds of BV. Literature of the main biological activities exerted by BV shows that most studies focuses on the comprehension and test of anti-inflammatory effects and its mechanisms of action. Other properties such as antioxidant, antimicrobial, neuroprotective or antitumor effects have also been assessed, both in vitro and in vivo. Moreover, human trials are necessary to confirm those clinical applications. However, notwithstanding the therapeutic potential of BV, there are certain problems regarding its safety and the possible appearance of adverse effects. On this perspective, new approaches have been developed to avoid these complications. This manuscript is aimed at reviewing the actual knowledge on BV components and its associated biological activities as well as the latest advances on this subject.

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Role of apamin-sensitive small conductance calcium-activated potassium currents in long-term cardiac memory in rabbits

Abstract: Chronic ventricular pacing increases Ca transients at late activation sites, which activates I to maintain repolarization reserve. I blockade increases VF vulnerability in chronically paced rabbit ventricles.

Cited by 6 publications

References 24 publications

Effects of ondansetron on apamin-sensitive small conductance calcium-activated potassium currents in pacing-induced failing rabbit hearts

Effects of ondansetron on apamin-sensitive small conductance calcium-activated potassium currents in pacing-induced failing rabbit hearts

Proinflammatory Cytokine Modulates Intracellular Calcium Handling and Enhances Ventricular Arrhythmia Susceptibility

Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications

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